Evaluating and Enhancing Japanese Large Language Models for Genetic Counseling Support: Comparative Study of Domain Adaptation and the Development of an Expert-Evaluated Dataset

Takuya Fukushima   ¹ , BE ;   Masae Manabe   ² , MEd ;   Shuntaro Yada   ^{1, 3} , PhD ;   Shoko Wakamiya   ¹ , PhD ;   Akiko Yoshida   ⁴ , PhD ;   Yusaku Urakawa   ^{5, 6, 7} , MD, PhD ;   Akiko Maeda   ⁵ , MD, PhD ;   Shigeyuki Kan   ⁸ , PhD ;   Masayo Takahashi   ⁸ , MD, PhD ;   Eiji Aramaki   ¹ , PhD

¹ Graduate School of Science and Technology, Nara Institute of Science and Technology, Ikoma, Japan

² Research Administration Center, Kyoto University, Kyoto, Japan

³ Faculty of Library, Information and Media Science, University of Tsukuba, Tsukuba, Japan

⁴ Department of Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

⁵ Kobe City Eye Hospital, Kobe, Japan

⁶ Department of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, Japan

⁷ Department of Genomic Medicine, School of Medicine, Fujita Health University, Toyoake, Japan

⁸ Vision Care Inc, Kobe, Japan