JMIR Medical Informatics

Atrial fibrillation (AF) is a common arrhythmia associated with an increased risk of stroke and heart failure. To improve prevention, recent studies have used deep learning models to identify at-risk individuals early from normal sinus rhythm (NSR). However, studies using mobile electrocardiogram (mECG) in outpatient, real-world settings remain underexplored.

Large language models (LLMs) are rapidly evolving from text-based agents to multimodal systems capable of interpreting medical images. While their textual reasoning has improved, the safety implications of this shift remain underexplored, specifically regarding the alignment between visual interpretation and textual advice in low back pain (LBP) management.

Despite advances in understanding and treating non–ST-elevation acute coronary syndrome (NSTE-ACS), patients continue to experience high rates of adverse outcomes, particularly those with non–ST-segment elevation myocardial infarction, which remains a leading cause of cardiovascular mortality. Existing risk models may not fully reflect contemporary patient populations due to substantial changes in clinical profiles. Developing new machine learning (ML)–based risk calculators may improve the prediction of in-hospital mortality (IHM) at different stages of the diagnostic process, and ultimately improve patient outcomes.

Screening for atherosclerosis is essential for early intervention, but conventional screening methods are often invasive and resource-intensive. As a result, there is growing interest in leveraging AI with noninvasive tools such as retinal fundus imaging to enable opportunistic cardiovascular risk assessment. The deep-learning funduscopic atherosclerosis score (DL-FAS) is an AI-derived biomarker, generated by a deep learning model, that was developed in a previous study to reflect the likelihood of carotid artery atherosclerosis from retinal fundus images.

Telemedicine may improve access to specialized care, but its use for supervision during critical anesthesia situations remains underexplored. A standardized tele-supervision (TSV) solution for operating rooms (ORs) is lacking.

Efficiently finding and exploring relevant health studies is critical for informed, evidence-based health care. However, study information remains distributed across multiple resources, hindering interoperability, search, and reuse. Enhancing the findability of study data is a key challenge in promoting the findability, accessibility, interoperability, and reusability (FAIR) principles in health research.

The prediction of weaning from mechanical ventilation (MV) can support clinical decision-making and help reduce the risk of weaning failure in intensive care units (ICUs). Cross-silo federated learning (FL) offers a promising approach to developing robust predictive models across multiple institutions without requiring the sharing of patient-level data.

Sepsis-associated acute kidney injury (SA-AKI) is a frequent and life-threatening complication of sepsis. While the static lactate-to-albumin ratio (LAR) has prognostic value, its dynamic temporal evolution during early resuscitation and its utility for guiding clinical risk stratification remain underexplored.

Widespread and sustained uptake of AI-based clinical decision support systems (CDSSs) in real-world health care settings is uncommon, despite their potential to improve patient care and reduce clinician burnout. Although previous studies have examined determinants of implementing AI-based CDSSs, limited evidence has synthesized barriers and facilitators identified during actual clinical implementation and use.

Overactive bladder (OAB) is a prevalent condition, particularly among women, characterized by urinary urgency, often accompanied by frequency and nocturia. Traditional risk prediction methods for OAB are limited, as they fail to fully integrate multidimensional risk factors, including female reproductive history. Machine learning offers potential for enhanced predictive accuracy by using large-scale datasets like the National Health and Nutrition Examination Survey (NHANES).

Accurate forecasting of influenza-like illness (ILI) is crucial for public health. Integrating novel digital data streams (eg, internet searches and human mobility) with traditional surveillance can improve accuracy, but optimal modeling frameworks are underexplored.