Analyzing Medical Research Results Based on Synthetic Data and Their Relation to Real Data Results: Systematic Comparison From Five Observational Studies

Anat Reiner Benaim   ¹ , PhD ;   Ronit Almog   ^{1, 2} , MPH, MD ;   Yuri Gorelik   ³ , MD ;   Irit Hochberg   ^{4, 5} , MD, PhD ;   Laila Nassar   ⁶ , PharmD ;   Tanya Mashiach   ¹ , MA ;   Mogher Khamaisi   ^{3, 4, 7} , MD, PhD ;   Yael Lurie   ^{5, 6} , MD ;   Zaher S Azzam   ^{8, 9} , MD, FESC ;   Johad Khoury   ⁸ , MD ;   Daniel Kurnik   ^{5, 10} , MD ;   Rafael Beyar   ^{5, 11} , MD, DSC, MPH

¹ Clinical Epidemiology Unit, Rambam Health Care Campus, Haifa, Israel

² School of Public Health, University of Haifa, Haifa, Israel

³ Department of Internal Medicine D, Rambam Health Care Campus, Haifa, Israel

⁴ Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Haifa, Israel

⁵ The Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

⁶ Clinical Pharmacology and Toxicology Section, Rambam Health Care Campus, Haifa, Israel

⁷ Diabetes Stem Cell Laboratory, Rambam Health Care Campus, Haifa, Israel

⁸ Department of Internal Medicine B, Rambam Health Care Campus, Haifa, Israel

⁹ The Ruth & Bruce Rappaport Faculty of Medicine and Rappaport Research Institute, Technion-Israel Institute of Technology, Haifa, Israel

¹⁰ Clinical Pharmacology Unit, Rambam Health Care Campus, Haifa, Israel

¹¹ Rambam Health Care Campus, Haifa, Israel