Machine Learning Electronic Health Record Identification of Patients with Rheumatoid Arthritis: Algorithm Pipeline Development and Validation Study

Tjardo D Maarseveen   ¹ , BSc ;   Timo Meinderink   ^{2, 3} , MSc ;   Marcel J T Reinders   ^{4, 5} , PhD ;   Johannes Knitza   ^{2, 3} , MD ;   Tom W J Huizinga   ¹ , MD ;   Arnd Kleyer   ^{2, 3} , MD ;   David Simon   ^{2, 3} , MD ;   Erik B van den Akker   ^{4, 5} , PhD ;   Rachel Knevel   ^{1, 6} , MD

¹ Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

² Department of Internal Medicine 3, Friedrich-Alexander University Erlangen‐Nuremberg, Erlangen, Germany

³ Deutsches Zentrum für Immuntherapie, Erlangen-Nuremberg and Universitätsklinikum, Erlangen, Germany

⁴ Leiden Computational Biology Centre, Leiden University Medical Center, Leiden, Netherlands

⁵ Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands

⁶ Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States