Combining Machine Learning With Real-World Data to Identify Gaps in Clinical Practice Guidelines: Feasibility Study Using the Prospective German Stroke Registry and the National Acute Ischemic Stroke Guidelines

Sandrine Müller   ¹ , MSc ;   Susanne Diekmann   ¹ , Dr med ;   Markus Wenzel   ^{1, 2} , Prof Dr-Ing ;   Horst Karl Hahn   ^{1, 3} , Prof Dr-Ing ;   Johannes Tuennerhoff   ^{4, 5} , Dr med ;   Ulrike Ernemann   ⁶ , Prof Dr Med ;   Florian Hennersdorf   ⁶ , Dr med ;   German Stroke Registry Investigators   ;   Max Westphal   ¹ , Dr rer nat ;   Sven Poli   ^{4, 5} , Prof Dr Med

¹ Fraunhofer Institute for Digital Medicine, Bremen, Germany

² Constructor University, Bremen, Germany

³ Department of Mathematics and Computer Science, University of Bremen, Bremen, Germany

⁴ Department of Neurology & Stroke, University of Tübingen, Tübingen, Germany

⁵ Hertie Institute for Clinical Brain Research, Tübingen, Germany

⁶ Department of Diagnostic and Interventional Neuroradiology, University of Tübingen, Tübingen, Germany