Detecting Adverse Drug Events Through the Chronological Relationship Between the Medication Period and the Presence of Adverse Reactions From Electronic Medical Record Systems: Observational Study

Kei Teramoto   ^{1, 2 *} , MS ;   Toshihiro Takeda   ^{1 *} , MD, PhD ;   Naoki Mihara   ³ , MD, PhD ;   Yoshie Shimai   ¹ , PhD ;   Shirou Manabe   ¹ , MS ;   Shigeki Kuwata   ⁴ , PhD ;   Hiroshi Kondoh   ² , MD, PhD ;   Yasushi Matsumura   ¹ , MD, PhD

¹ Department of Medical Informatics, Graduate School of Medicine, Osaka University, Suita, Japan

² Division of Medical Informatics, Tottori University Hospital, Yonago, Japan

³ Department of Medical Informatics, National Cancer Center Hospital, Tokyo, Japan

⁴ Department of Clinical Information Management, Nara City Hospital, Nara, Japan

*these authors contributed equally