Machine Learning Prediction of Pharmacogenetic Testing Uptake Among Opioid-Prescribed Patients Using Electronic Health Records: Retrospective Cohort Study

Mohammad Yaseliani   ¹ , MSc ;   Je-Won Hong   ² , PharmD ;   Jiang Bian   ^{3, 4} , MS, PhD ;   Larisa Cavallari   ^{2, 5} , PharmD ;   Julio D Duarte   ^{2, 5} , PharmD, PhD ;   Danielle Nelson   ⁶ , MPH, MD ;   Wei-Hsuan Lo-Ciganic   ^{7, 8, 9} , MSPharm, MS, PhD ;   Khoa Anh Nguyen   ^{2 *} , PharmD ;   Md Mahmudul Hasan   ^{1, 10 *} , PhD

¹ Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States

² Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, United States

³ Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, IN, United States

⁴ Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, IN, United States

⁵ Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, FL, United States

⁶ College of Medicine, University of Florida, Gainesville, FL, United States

⁷ Division of General Internal Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States

⁸ Center for Pharmaceutical Policy and Prescribing, University of Pittsburgh, Pittsburgh, PA, United States

⁹ Geriatric Research Education and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, United States

¹⁰ Department of Information Systems and Operations Management, Warrington College of Business, University of Florida, Gainesville, FL, United States

*these authors contributed equally