Development Process of a Clinical Decision Support System for Empiric Antibiotic Therapies in Patients With Sepsis: Case Study

Sophie Schmiegel   ^{1 *} , MSc ;   Hannah Marchi   ^{1 *} , MSc ;   Philipp Hege   ¹ , MSc ;   Svenja Elkenkamp   ² , MEd, MSc ;   Juliane Duevel   ^{2, 3} , MSc ;   Christoph Düsing   ⁴ , Dr rer nat ;   Wolfgang Greiner   ² , Prof Dr ;   Sean Selim Scholz   ⁵ , Priv-Doz, Dr med, MHBA ;   Dominic Witzke   ⁵ ;   Johannes J Tebbe   ⁶ , Prof Dr med ;   Michael Wehmeier   ⁷ , Dr med Dipl-Biochem ;   Olaf Kaup   ⁷ , Dr rer nat Dipl-Biochem ;   Rainer Borgstedt   ⁵ , Dr med ;   Sebastian Rehberg   ⁵ , Prof Dr med ;   Philipp Cimiano   ⁴ , Prof Dr ;   Christiane Fuchs   ^{1, 8} , Prof Dr

¹ Data Science Group, Faculty of Business Administration and Economics, Bielefeld University, Bielefeld, Germany

² AG 5 - Health Economics and Health Care Management, School of Public Health, Bielefeld University, Bielefeld, Germany

³ Centre for electronic Public Health Research (CePHR),, School of Public Health, Bielefeld University, Bielefeld, Germany

⁴ Center for Cognitive Interaction Technology (CITEC), Faculty of Technology, Bielefeld University, Bielefeld, Germany

⁵ Department of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, Medical School and University Medical Center OWL, Bielefeld University, Protestant Hospital of the Bethel Foundation, Bielefeld, Germany

⁶ Division of Internal Medicine, Department of Gastroenterology and Infectiology, Medical School and University Medical Center OWL, Bielefeld University, Klinikum Lippe, Detmold, Germany

⁷ Institute of Laboratory Medicine, Microbiology and Transfusion Medicine, Klinikum Bielefeld, Bielefeld, Germany

⁸ Institute of Computational Biology, Computational Health Center, Helmholtz Munich, Oberschleißheim, Germany

*these authors contributed equally