Predicting Antituberculosis Drug–Induced Liver Injury Using an Interpretable Machine Learning Method: Model Development and Validation Study

Tao Zhong   ^{1 *} , BSc ;   Zian Zhuang   ^{2, 3, 4 *} , BSc ;   Xiaoli Dong   ^{5, 6} , PhD ;   Ka Hing Wong   ^{5, 6} , PhD ;   Wing Tak Wong   ^{5, 6} , PhD ;   Jian Wang   ¹ , BSc ;   Daihai He   ^{2, 4} , PhD ;   Shengyuan Liu   ¹ , PhD

¹ Department of Tuberculosis Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China

² Department of Applied Mathematics, The Hong Kong Polytechnic University, Hong Kong, China

³ Department of Biostatistics, University of California, Los Angeles, CA, United States

⁴ Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China

⁵ Research Institute for Future Food, The Hong Kong Polytechnic University, Hong Kong, China

⁶ Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China

*these authors contributed equally