Drug Repurposing and Off-Label Use

Detection of Clinically Significant Drug-Drug Interactions in Fatal Torsades de Pointes: Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System

Huanhuan Ji, Meiling Gong, Li Gong, Ni Zhang, Ruiou Zhou, Dongmei Deng, Ya Yang, Lin Song, Yuntao Jia

J Med Internet Res 2025 (Mar 25); 27:e65872

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Impact of Preventive Intravenous Amiodarone on Reperfusion Ventricular Fibrillation in Patients With Left Ventricular Hypertrophy Undergoing Open-Heart Surgery: Randomized Controlled Clinical Trial

Chan-Juan Gong, Xiao-Kai Zhou, Zhen-Feng Zhang, Yin Fang

JMIR Form Res 2025 (Jan 13); 9:e64586

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Association Between X/Twitter and Prescribing Behavior During the COVID-19 Pandemic: Retrospective Ecological Study

Scott A Helgeson, Rohan M Mudgalkar, Keith A Jacobs, Augustine S Lee, Devang Sanghavi, Pablo Moreno Franco, Ian S Brooks, National COVID Cohort Collaborative (N3C)

JMIR Infodemiology 2024 (Nov 18); 4:e56675

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Multifactor Quality and Safety Analysis of Semaglutide Products Sold by Online Sellers Without a Prescription: Market Surveillance, Content Analysis, and Product Purchase Evaluation Study

Amir Reza Ashraf, Tim Ken Mackey, Róbert György Vida, Győző Kulcsár, János Schmidt, Orsolya Balázs, Bálint Márk Domián, Jiawei Li, Ibolya Csákó, András Fittler

J Med Internet Res 2024 (Nov 07); 26:e65440

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The Alzheimer’s Knowledge Base: A Knowledge Graph for Alzheimer Disease Research

Joseph D Romano, Van Truong, Rachit Kumar, Mythreye Venkatesan, Britney E Graham, Yun Hao, Nick Matsumoto, Xi Li, Zhiping Wang, Marylyn D Ritchie, Li Shen, Jason H Moore

J Med Internet Res 2024 (Apr 18); 26:e46777

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The Efficacy of Bepotastine Besilate Compared With Hydroxyzine Pamoate for Preventing Infusion Reactions to the First Dose of Rituximab in Patients With Non-Hodgkin Lymphoma: Protocol for a Phase II, Double-Blind, Multicenter Randomized Trial

Yumi Kitahiro, Kazuhiro Yamamoto, Kimikazu Yakushijin, Takeshi Ioroi, Masaaki Tanda, Kotaro Itohara, Tomohiro Omura, Hironobu Minami, Ikuko Yano

JMIR Res Protoc 2024 (Feb 22); 13:e54882

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Using Transformer-Based Topic Modeling to Examine Discussions of Delta-8 Tetrahydrocannabinol: Content Analysis

Brandi Patrice Smith, Brooke Hoots, Lara DePadilla, Douglas R Roehler, Kristin M Holland, Daniel A Bowen, Steven A Sumner

J Med Internet Res 2023 (Dec 21); 25:e49469

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Drug Repurposing for Cancers With Limited Survival: Protocol for a Retrospective Cohort Study

Alejandro Rodríguez-Molinero, Carlos Pérez-López, Jose L Salazar González, Esther Garcia-Lerma, Juan A Álvarez-García, Luis M Soria Morillo, Tomás Salas Fernández

JMIR Res Protoc 2023 (Nov 14); 12:e48925

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The Efficacy, Safety, and Efficiency of the Off-Label Use of Bevacizumab in Patients Diagnosed With Age-Related Macular Degeneration: Protocol for a Systematic Review and Meta-Analysis

João Estarreja, Priscila Mendes, Carina Silva, Pedro Camacho, Vanessa Mateus

JMIR Res Protoc 2023 (Jun 09); 12:e38658

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The Identification of Potential Drugs for Dengue Hemorrhagic Fever: Network-Based Drug Reprofiling Study

Praveenkumar Kochuthakidiyel Suresh, Gnanasoundari Sekar, Kavya Mallady, Wan Suriana Wan Ab Rahman, Wan Nazatul Shima Shahidan, Gokulakannan Venkatesan

JMIR Bioinform Biotech 2023 (May 09); 4:e37306

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Social Media Mining of Long-COVID Self-Medication Reported by Reddit Users: Feasibility Study to Support Drug Repurposing

Jonathan Koss, Sabine Bohnet-Joschko

JMIR Form Res 2022 (Oct 03); 6(10):e39582

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COVID-19 Treatments Sold Online Without Prescription Requirements in the United States: Cross-sectional Study Evaluating Availability, Safety and Marketing of Medications

Sachiko Ozawa, Joanna Billings, Yujiao Sun, Sushan Yu, Benjamin Penley

J Med Internet Res 2022 (Feb 16); 24(2):e27704

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A Venomics Approach to the Identification and Characterization of Bioactive Peptides From Animal Venoms for Colorectal Cancer Therapy: Protocol for a Proof-of-Concept Study

Syeda Kiran Shahzadi, Noushad Karuvantevida, Yajnavalka Banerjee

JMIR Res Protoc 2021 (Dec 21); 10(12):e31128

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ClinicalTrials.gov as a Source of Information About Expanded Access Programs: Cohort Study

Jan Borysowski, Andrzej Górski

J Med Internet Res 2021 (Oct 28); 23(10):e26890

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Pharmacokinetics and Perceptions of Children and Young Adults Using Cannabis for Attention-Deficit/Hyperactivity Disorder and Oppositional Defiant Disorder: Protocol for a Mixed Methods Proof-of-Concept Study

Holly Mansell, Declan Quinn, Lauren E Kelly, Michael Szafron, Jane Alcorn

JMIR Res Protoc 2021 (Oct 18); 10(10):e31281

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Combining Ketamine and Internet-Based Cognitive Behavioral Therapy for the Treatment of Posttraumatic Stress Disorder: Protocol for a Randomized Controlled Trial

Aaron Emile Philipp-Muller, Taras Reshetukha, Gustavo Vazquez, Roumen Milev, Dawn Armstrong, Jasleen Jagayat, Nazanin Alavi

JMIR Res Protoc 2021 (Jul 20); 10(7):e30334

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Self-reported Subjective Effects of Analytically Confirmed New Psychoactive Substances Consumed by e-Psychonauts: Protocol for a Longitudinal Study Using a New Internet-Based Methodology

Marc Grifell, Guillem Mir Fuster, Mireia Ventura Vilamala, Liliana Galindo Guarín, Xoán Carbón Mallol, Carl L Hart, Víctor Pérez Sola, Francesc Colom Victoriano

JMIR Res Protoc 2021 (Jul 02); 10(7):e24433

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Treatment of Barth Syndrome by Cardiolipin Manipulation (CARDIOMAN) With Bezafibrate: Protocol for a Randomized Placebo-Controlled Pilot Trial Conducted in the Nationally Commissioned Barth Syndrome Service

Lucy Dabner, Guido E Pieles, Colin G Steward, Julian P Hamilton-Shield, Andrew R Ness, Chris A Rogers, Chiara Bucciarelli-Ducci, Rosemary Greenwood, Lucy Ellis, Karen Sheehan, Barnaby C Reeves

JMIR Res Protoc 2021 (May 31); 10(5):e22533

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Impact of Trump's Promotion of Unproven COVID-19 Treatments and Subsequent Internet Trends: Observational Study

Kacper Niburski, Oskar Niburski

J Med Internet Res 2020 (Nov 23); 22(11):e20044

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Toward Preparing a Knowledge Base to Explore Potential Drugs and Biomedical Entities Related to COVID-19: Automated Computational Approach

Junaed Younus Khan, Md Tawkat Islam Khondaker, Iram Tazim Hoque, Hamada R H Al-Absi, Mohammad Saifur Rahman, Reto Guler, Tanvir Alam, M Sohel Rahman

JMIR Med Inform 2020 (Nov 10); 8(11):e21648

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