System Architecture and Operational Principles for a Configurable Clinical Decision Support System for Model-Informed Precision Dosing: Development, Verification, and Validation Study

Roberto Rigamonti   ^{1 *} , PhD ;   Yuan James Pétermann   ^{2, 3 *} , PharmD, PhD ;   Melvyn Herzig   ¹ , BSc ;   Annie Ester Cathignol   ^{1, 4} , MSc ;   Bruno Da Rocha Carvalho   ¹ , BSc ;   Stellah George Mpagama   ⁵ , Dr Med ;   Bibie Said   ^{5, 6} , MD ;   Margaretha Laurent Sariko   ⁷ , PhD ;   Chantal Csajka   ^{2, 8, 9} , PhD ;   Monia Guidi   ^{2, 3, 8 *} , PhD ;   Yann Thoma   ^{1 *} , PhD

¹ School of Engineering and Management Vaud, HES-SO University of Applied Sciences and Arts Western Switzerland, Yverdon-les-Bains, Vaud, Switzerland

² Centre for Research and Innovation in Clinical Pharmaceutical Sciences, University Hospital of Lausanne, Lausanne, Vaud, Switzerland

³ Department of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Lausanne, Vaud, Switzerland

⁴ Faculty of Biology and Medicine, University of Lausanne, Lausanne, Vaud, Switzerland

⁵ Kibong'oto Infectious Diseases Hospital, Sanya Juu, United Republic of Tanzania

⁶ The Nelson Mandela African Institution of Science and Technology, Arusha, United Republic of Tanzania

⁷ Kilimanjaro Clinical Research Institute, Moshi, United Republic of Tanzania

⁸ Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva and University of Lausanne, Geneva & Lausanne, Switzerland

⁹ School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland

*these authors contributed equally