Safety and Performance Evaluation of a Clinical Decision Support System for Imatinib Therapeutic Drug Monitoring: In Silico Study

Yuan James Pétermann   ^{1, 2 *} , PharmD, PhD ;   Roberto Rigamonti   ^{3 *} , PhD ;   Paul Thoueille   ² , PharmD, PhD ;   Junrui Chen   ⁴ , PhD ;   Lavinia Alberi   ⁵ , PhD ;   Alexandra Simon   ² , BSc ;   François Veuve   ² , MSc ;   Eva Choong   ² , PD, PhD ;   Bruno Da Rocha Carvalho   ³ , BSc ;   Sandro Carrara   ⁴ , PhD ;   François R Girardin   ² , MD ;   Thierry Buclin   ² , MD ;   Chantal Csajka   ^{1, 6} , PhD ;   Yann Thoma   ^{3 *} , PhD ;   Monia Guidi   ^{1, 2, 6 *} , PhD

¹ Centre for Research and Innovation in Clinical Pharmaceutical Sciences, University Hospital of Lausanne and University of Lausanne, Lausanne, Vaud, Switzerland

² Department of Clinical Pharmacology, University Hospital of Lausanne and University of Lausanne, Lausanne, Vaud, Switzerland

³ School of Engineering and Management Vaud, HES-SO University of Applied Sciences and Arts Western Switzerland, Yverdon-les-Bains, Vaud, Switzerland

⁴ Bio/CMOS Interfaces Lab, École Polytechnique Fédérale de Lausanne, Lausanne, Vaud, Switzerland

⁵ VitalizeDx, Lausanne, Vaud, Switzerland

⁶ Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Geneva & Lausanne, Switzerland

*these authors contributed equally