Published on in Vol 9, No 4 (2021): April

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/21547, first published .

Jenna M Reps   1 , BSc, MSc, PhD ;   Chungsoo Kim   2 , PharmD ;   Ross D Williams   3 , MSc ;   Aniek F Markus   3 , BSc, MSc ;   Cynthia Yang   3 , BSc, MSc ;   Talita Duarte-Salles   4 , MPH, PhD ;   Thomas Falconer   5 , BSc, MSc ;   Jitendra Jonnagaddala   6 , MIS, PhD ;   Andrew Williams   7 , PhD ;   Sergio Fernández-Bertolín   4 , MSc ;   Scott L DuVall   8 , PhD ;   Kristin Kostka   9 , MPH ;   Gowtham Rao   1 , MD, PhD ;   Azza Shoaibi   1 , PhD ;   Anna Ostropolets   5 , MD ;   Matthew E Spotnitz   5 , MPH, MD ;   Lin Zhang   10, 11 , PhD ;   Paula Casajust   12 , BSc, MSc ;   Ewout W Steyerberg   13, 14 , MSc, PhD ;   Fredrik Nyberg   15 , MPH, MD, PhD ;   Benjamin Skov Kaas-Hansen   16, 17 , MSc, MD ;   Young Hwa Choi   18 , MD, PhD ;   Daniel Morales   19 , PhD, MBChB ;   Siaw-Teng Liaw   6 , PhD ;   Maria Tereza Fernandes Abrahão   20 , PhD ;   Carlos Areia   21 , MSc, PT ;   Michael E Matheny   22 , MD, MPH, MS ;   Kristine E Lynch   8 , PhD ;   María Aragón   4 , MSc ;   Rae Woong Park   23 , MD, PhD ;   George Hripcsak   5 , MD, MS ;   Christian G Reich   9 , MD, PhD ;   Marc A Suchard   24 , MD, PhD ;   Seng Chan You   23 , MD, MS ;   Patrick B Ryan   1 , PhD ;   Daniel Prieto-Alhambra   25 , MD, PhD ;   Peter R Rijnbeek   3 , PhD

1 Janssen Research & Development, Titusville, NJ, United States

2 Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Republic of Korea

3 Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands

4 Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol i Gurina, Barcelona, Spain

5 Department of Biomedical Informatics, Columbia University, New York, NY, United States

6 School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia

7 Tufts Institute for Clinical Research and Health Policy Studies, Boston, MA, United States

8 Department of Veterans Affairs, University of Utah, Salt Lake City, UT, United States

9 Real World Solutions, IQVIA, Cambridge, MA, United States

10 Melbourne School of Public Health, The University of Melbourne, Victoria, Australia

11 School of Public Health, Peking Union Medical College, Beijing, China

12 Department of Real-World Evidence, Trial Form Support, Barcelona, Spain

13 Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands

14 Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands

15 School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

16 Clinical Pharmacology Unit, Zealand University Hospital, Roskilde, Denmark

17 NNF Centre for Protein Research, University of Copenhagen, Copenhagen, Denmark

18 Department of Infectious Diseases, Ajou University School of Medicine, Suwon, Republic of Korea

19 Division of Population Health and Genomics, University of Dundee, Dundee, United Kingdom

20 Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil

21 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

22 Department of Veterans Affairs, Vanderbilt University, Nashville, TN, United States

23 Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Republic of Korea

24 Department of Biostatistics, UCLA Fielding School of Public Health, University of California, Los Angeles, CA, United States

25 Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

Corresponding Author:

  • Jenna M Reps, BSc, MSc, PhD
  • Janssen Research & Development
  • 1125 Trenton Harbourton Rd
  • Titusville, NJ
  • United States
  • Phone: 1 732-715-6300
  • Email: jreps@its.jnj.com