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Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer

Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer

Dutta et al [50] recently reported that the aggressiveness of PDAC is directly correlated to pyruvate-to-lactate conversion measured using HP-MR (Table 1) and ex vivo 1 H nuclear magnetic resonance (NMR) spectroscopy in a panel of well-annotated patient-derived PDAC xenograft (PDX) mouse models. The ex vivo 1 H NMR spectroscopy results were also in good agreement with in vivo pyruvate-to-lactate conversion, showing a higher abundance of lactate in aggressive tumors.

José S Enriquez, Yan Chu, Shivanand Pudakalakatti, Kang Lin Hsieh, Duncan Salmon, Prasanta Dutta, Niki Zacharias Millward, Eugene Lurie, Steven Millward, Florencia McAllister, Anirban Maitra, Subrata Sen, Ann Killary, Jian Zhang, Xiaoqian Jiang, Pratip K Bhattacharya, Shayan Shams

JMIR Med Inform 2021;9(6):e26601