Data-Driven Identification of Factors That Influence the Quality of Adverse Event Reports: 15-Year Interpretable Machine Learning and Time-Series Analyses of VigiBase and QUEST

Sim Mei Choo   ^{1, 2} , MSc ;   Daniele Sartori   ³ , MSc ;   Sing Chet Lee   ¹ , MSc ;   Hsuan-Chia Yang   ^{2, 4, 5, 6 *} , PhD ;   Shabbir Syed-Abdul   ^{2, 4, 7 *} , MD, PhD

¹ Centre of Compliance & Quality Control, National Pharmaceutical Regulatory Agency, Petaling Jaya, Malaysia

² Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, Taiwan

³ Uppsala Monitoring Centre, Uppsala, Sweden

⁴ International Center for Health Information Technology, Taipei Medical University, Taipei, Taiwan

⁵ Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan

⁶ Research Center of Big Data and Meta-Analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

⁷ School of Gerontology and Long-Term Care, Taipei Medical University, Taipei, Taiwan

*these authors contributed equally