e.g. mhealth
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Skip search results from other journals and go to results- 21 Journal of Medical Internet Research
- 12 JMIR Research Protocols
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In this research, we aim to establish a multicenter sepsis database (MSD), providing a richer and more diverse dataset that is crucial for the in-depth analysis and understanding of sepsis. Using GPT4.0 for entity recognition and relation extraction, we aim to construct a comprehensive sepsis knowledge graph, using real-world databases supplemented by clinical guidelines and relevant public databases.
J Med Internet Res 2025;27:e65537
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GPT-3.5 Turbo and GPT-4 Turbo in Title and Abstract Screening for Systematic Reviews
We conducted a post hoc analysis of our previous study to evaluate the performance of GPT-3.5 Turbo and GPT-4 Turbo in LLM-assisted title and abstract screening, using data from 5 clinical questions (CQs) developed for the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024 [6,10].
JMIR Med Inform 2025;13:e64682
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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection [1-3]. While mortality from sepsis has decreased over time after age standardization, it remains high [2-6]. According to the Global Burden of Disease Study, 48.9 million cases of sepsis were reported worldwide in 2017, accounting for 11 million deaths [7].
Interact J Med Res 2025;14:e63291
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Sepsis infections caused by pathogens with antimicrobial resistance (AMR) represent a significant global challenge in health care [1,2]. In 2017, there were 48.9 million new cases of sepsis and 11 million deaths related to sepsis, accounting for 19.7% of all global deaths [3]. In Germany, sepsis incidence increased by an average of 5.7% per year, from 280 cases in 2010 to 370 cases in 2015 per 100,000 individuals [4].
JMIR Hum Factors 2025;12:e66699
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In addition, they are usually ordered when sepsis is clinically suspected, leading to a diagnostic delay [7] and making them unsuitable as a screening tool. The ideal biomarker for sepsis screening should have the following characteristics: (1) easy to measure, (2) high sensitivity and negative predictive value for sepsis, (3) low turn-around time, and (4) always available to clinicians, especially when sepsis is not (yet) suspected. Complete blood count (CBC) parameters fulfill all of these features [8].
J Med Internet Res 2025;27:e55492
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Treatment of the dysregulated immune response as a cause of sepsis has not been successful in large trials and subsequently has therefore not found its way into clinical practice or sepsis guidelines.
AI-based CDSS could be particularly useful in sepsis care due to the high heterogeneity and complexity of the disease [10]. Non–knowledge-based respectively data-based CDSS are subject to a trade-off between model complexity and interpretability.
JMIR Res Protoc 2025;14:e62704
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This confirms the critical role of specific blood parameters in sepsis detection and enhances our model’s interpretability and clinical relevance.
Correlation heat map of complete blood count with differential (CBC+DIFF) parameters and sepsis.
J Med Internet Res 2025;27:e56155
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Following the work of our previous study [7,11], we aimed to generalize our findings by applying the investigation to the delirium, sepsis, and AKI use cases at 1 community hospital and 1 specialized hospital.
J Med Internet Res 2024;26:e51409
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Recognizing SIRS has been a prerequisite of suspecting potential sepsis and implementing decisions such as sample culturing for the source of infection, escalating antibiotic regimens, and the level of patient monitor and care [2,3].
J Med Internet Res 2024;26:e57486
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A recent randomized controlled trial (RCT) in healthy volunteers provided definitive mechanistic evidence of Cyto Sorb’s ability to decrease systemic cytokine levels after intravenous administration of endotoxin in an established sepsis model [11].
JMIR Res Protoc 2024;13:e55880
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