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Development of a Comprehensive Decision Support Tool for Chemotherapy-Cycle Prescribing: Initial Usability Study

Development of a Comprehensive Decision Support Tool for Chemotherapy-Cycle Prescribing: Initial Usability Study

Before a new chemotherapy cycle, a patient’s laboratory values and symptoms were evaluated, for example, for indications of treatable chemotherapy side effects, excess chemotherapy toxicity, and cancer progression. To streamline this work process, increase the comprehensiveness and repeatability of the precycle evaluation, and automate duties, we developed a decision support tool.

Sanna Iivanainen, Reetta Arokoski, Santeri Mentu, Laura Lang, Jussi Ekström, Henri Virtanen, Vesa Kataja, Jussi Pekka Koivunen

JMIR Form Res 2025;9:e62749

Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer

Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer

End-of-treatment chemotherapy-induced peripheral neuropathy detection performance by Neuro Detect, CIPN20, and Combined Models. a CIPN-f: chemotherapy-induced peripheral neuropathy in the feet. b CIPN-h: chemotherapy-induced peripheral neuropathy in the hands. c CIPN20: 20-item scale. d NIR: no information rate. e P value testing accuracy of each Model versus the no information rate, which is the accuracy obtained by always predicting the majority class. f Significance level P Predicted chemotherapy-induced peripheral

Ciao-Sin Chen, Michael P Dorsch, Sarah Alsomairy, Jennifer J Griggs, Reshma Jagsi, Michael Sabel, Amro Stino, Brian Callaghan, Daniel L Hertz

J Med Internet Res 2025;27:e65615

Design and Use of Patient-Facing Electronic Patient-Reported Outcomes and Sensor Data Visualizations During Outpatient Chemotherapy

Design and Use of Patient-Facing Electronic Patient-Reported Outcomes and Sensor Data Visualizations During Outpatient Chemotherapy

Chemotherapy can cause significant symptoms that impact the quality of life [1]. Although electronic patient-reported outcome (e PRO) systems for collecting symptom ratings from patients have become increasingly common in cancer care, most of these are designed for clinicians, and fewer than half share data visualizations with the patients [2,3].

Christianna Bartel, Leeann Chen, Weiyu Huang, Qichang Li, Qingyang Li, Jennifer Fedor, Krina C Durica, Carissa A Low

JMIR Cancer 2025;11:e62711

Engagement With Daily Symptom Reporting, Passive Smartphone Sensing, and Wearable Device Data Collection During Chemotherapy: Longitudinal Observational Study

Engagement With Daily Symptom Reporting, Passive Smartphone Sensing, and Wearable Device Data Collection During Chemotherapy: Longitudinal Observational Study

Men and women aged 18 years or older who were undergoing chemotherapy for any solid tumor at a large academic cancer center, who owned a smartphone, who could read and write in English, and who had at least 2 chemotherapy cycles remaining were eligible to participate. In addition, 7 participants were recruited from a community research registry, and these participants were asked to self-report on if they met the above eligibility criteria.

Sean McClaine, Jennifer Fedor, Christianna Bartel, Leeann Chen, Krina C Durica, Carissa A Low

JMIR Cancer 2024;10:e57347

Efficacy of a WeChat-Based, Multidisciplinary, Full-Course Nutritional Management Program on the Nutritional Status of Patients With Ovarian Cancer Undergoing Chemotherapy: Randomized Controlled Trial

Efficacy of a WeChat-Based, Multidisciplinary, Full-Course Nutritional Management Program on the Nutritional Status of Patients With Ovarian Cancer Undergoing Chemotherapy: Randomized Controlled Trial

For patients in the usual care group, upon admission, patients were provided with admission counseling, given an explanation about the complications associated with chemotherapy, and given a chemotherapy care booklet and a leaflet on diet and nutrition. Before discharge, the patients were given the nutritional guidebook again. Responsible nurses made 1 telephone follow-up visit between chemotherapy sessions.

Xiaojuan Tian, Yan Liu, Jiahua Zhang, Lixiao Yang, Linyao Feng, Aidong Qi, Hanjiazi Liu, Pengju Liu, Ying Li

JMIR Mhealth Uhealth 2024;12:e56475

Impact of Patient Personality on Adherence to Oral Anticancer Medications: An Opportunity?

Impact of Patient Personality on Adherence to Oral Anticancer Medications: An Opportunity?

While oral anticancer medications have many advantages over parenteral chemotherapy, including eliminating the need for venous access devices, many patients struggle with adhering to their prescribed regimens. Whereas medication adherence rates among patients with chronic diseases on oral treatment are estimated at approximately 50%, adherence rates for oral anticancer medications are substantially lower, with studies reporting adherence rates as low as 30% to 46% in patients with cancer [1-3].

Mahtab Jafari, Alex Shahverdian, Gelareh Sadigh, Richard A Van Etten

JMIR Cancer 2024;10:e57199

Lessons Learned From Shared Decision-Making With Oral Anticoagulants: Viewpoint on Suggestions for the Development of Oral Chemotherapy Decision Aids

Lessons Learned From Shared Decision-Making With Oral Anticoagulants: Viewpoint on Suggestions for the Development of Oral Chemotherapy Decision Aids

In oncology, DAs have been used since at least the advent of the “Decision Board” in 1992 for adjuvant chemotherapy in node-negative breast cancer [9,10], and although considerable research exists on their use and efficacy in oncology as a whole, and products do exist commercially [11], there is little in the current literature examining the development and efficacy of DAs targeting the unique challenges of oral chemotherapy.

Daniel E McLoughlin, Fabiola M Moreno Echevarria, Sherif M Badawy

JMIR Cancer 2024;10:e56935

Effectiveness of Aerobic Training for Adverse Symptoms Related to Chemotherapy During Treatment: Protocol for a Randomized Controlled Trial With Cost-Effectiveness Assessment

Effectiveness of Aerobic Training for Adverse Symptoms Related to Chemotherapy During Treatment: Protocol for a Randomized Controlled Trial With Cost-Effectiveness Assessment

At least one-third of women undergoing adjuvant chemotherapy treatment for breast cancer are unable to complete the prescribed dose of treatment due to adverse effects, thus compromising the prognosis of the disease [5]. Physical exercise in patients with cancer during chemotherapy has been tested in randomized trials [5-11] and appears to improve physical function, fatigue, symptom burden, and the quality of life of patients, in addition to allowing the nonreduction of chemotherapy doses.

William de Lima Selles, Gisela Cristiane Miyamoto, Elinaldo da Conceição Santos, Cibelle Regina Lima Carmo, Giovanni Marini Moura, Giovanna Marques Frascoli Santos, Giovanna dos Santos Lopes, Diego Wisnieski Silva, Leticia Jeremias Ferreira Pereira, Adriana Claudia Lunardi

JMIR Res Protoc 2024;13:e60828

Association of Remote Patient-Reported Outcomes and Step Counts With Hospitalization or Death Among Patients With Advanced Cancer Undergoing Chemotherapy: Secondary Analysis of the PROStep Randomized Trial

Association of Remote Patient-Reported Outcomes and Step Counts With Hospitalization or Death Among Patients With Advanced Cancer Undergoing Chemotherapy: Secondary Analysis of the PROStep Randomized Trial

Patients with advanced cancer who receive chemotherapy often experience significant symptoms, declines in functional status, and hospitalization [1-3]. Patient-reported outcomes (PROs) measure symptom burden and well-being. In clinical trials, routine collection of PROs for patients with cancer undergoing treatment is associated with decreased acute care use and improved overall survival [4,5].

Christopher R Manz, Emily Schriver, William J Ferrell, Joelle Williamson, Jonathan Wakim, Neda Khan, Michael Kopinsky, Mohan Balachandran, Jinbo Chen, Mitesh S Patel, Samuel U Takvorian, Lawrence N Shulman, Justin E Bekelman, Ian J Barnett, Ravi B Parikh

J Med Internet Res 2024;26:e51059