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Skip search results from other journals and go to results- 4 JMIR Research Protocols
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Glaucoma is a leading cause of irreversible blindness worldwide [1]. Progressive degeneration of retinal ganglion cells (RGCs) and the optic nerve is the basic pathological characteristic of glaucoma [2]. Optic nerve protection is the focus of glaucoma treatment based on intraocular pressure (IOP) control. Neuroprotective targets include glutamate-induced neurotoxicity, nitric oxidase synthetase, neurotropins, calcium channel receptors, free radicals, vascular insufficiency, and the rho-kinase pathway [3].
JMIR Res Protoc 2025;14:e67737
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Glaucoma, the second leading cause of permanent blindness in the United States, is the acquired loss of retinal ganglion cells within the optic nerve, resulting in the progressive loss of peripheral vision [3,4]. The 2 most common types of glaucoma in the United States are primary open-angle glaucoma and primary angle-closure glaucoma, with most patients presenting asymptomatically until the optic nerve damage is severe enough [5].
JMIR Res Protoc 2025;14:e52650
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Artificial intelligence (AI) has emerged as a transformative force in optometry [1], particularly for glaucoma diagnosis. In this context, AI in optometry refers to the advanced algorithms that analyze complex data such as fundus photos and related patient data. These AI systems use techniques of image processing, computer vision, deep learning, and transfer learning to detect and diagnose glaucoma.
JMIR Med Inform 2025;13:e63109
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Acupuncture as Adjuvant Therapy for Glaucoma: Protocol for a Randomized Controlled Trial
Glaucoma is a chronic optic nerve disease involving progressive loss of retinal ganglion cells, necessitating long-term treatment with minimal side effects. Some patients may choose to supplement their conventional medical interventions with complementary or alternative medicine [1-3].
In complementary and alternative therapies, there is literature on treating glaucoma with acupuncture, auricular acupressure [4], herbal medicine [5,6], nutritional supplements [7], and Ayurvedic medicine [8].
JMIR Res Protoc 2024;13:e57888
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Reflecting on Decades of Data: The Global Burden of Disease–Cochrane Project
For example, a review of ophthalmologic conditions showed that trachoma, onchocerciasis, vitamin A deficiency, and refraction and accommodation disorders were all underrepresented in the CDSR, while glaucoma, macular degeneration, and other vision loss disorders were overrepresented [5]. Other completed projects have shown poor representation of tropical diseases, while mental health and behavioral conditions are overrepresented [6,7].
JMIR Dermatol 2024;7:e41323
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Accumulating evidence indicates that melatonin has a protective effect against various ocular disorders, such as uveitis, diabetic retinopathy, glaucoma, and even optic neuritis, through different mechanisms of action [60,61,73,112-115]. The multifaceted role of melatonin in neuroprotection might imply that melatonin may possess the capacity to attenuate the harmful effects that occur in degenerative retinal diseases, such as RP.
JMIR Res Protoc 2023;12:e49196
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Glaucoma is one such leading cause of irreversible VI that is often detected late due to a lack of disease awareness and the often asymptomatic nature of early disease [8,9].
Disruptions in patient care due to the pandemic necessitated the redesigning of clinical workflows to ensure continued clinical service delivery across many medical disciplines, including ophthalmology [3,10,11].
J Med Internet Res 2023;25:e45044
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Early phases of glaucoma have no symptoms or visual field changes [8]. As the disease progresses, a slow narrowing of the visual field can occur. If left untreated, glaucoma may contribute to total blindness [9]. Loss of vision usually begins on the eye’s side and then approaches the middle.
J Med Internet Res 2021;23(9):e27414
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Acceptance of a Smartphone-Based Visual Field Screening Platform for Glaucoma: Pre-Post Study
Glaucoma is the leading cause of irreversible blindness worldwide, affecting approximately 64 million people [1,2]. A large proportion of glaucoma cases worldwide are undiagnosed or suboptimally managed [3]. More than half of the people living with the disease in low-income countries are unaware of the condition until it progresses to an advanced stage resulting in visual impairment [4,5]. As blindness caused by glaucoma is irreversible, early detection of the disease is critical [6].
JMIR Form Res 2021;5(9):e26602
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Color fundus camera imaging is an essential and easy-to-master technique for detecting a variety of eye diseases, such as diabetic retinopathy (DR) [6], age-related macular degeneration (AMD) [7], glaucoma [8], cataracts [9], and myopia [10,11]. However, in most countries, especially in low-income countries or regions with insufficient medical resources, there are not enough highly skilled ophthalmologists engaged in eye screening.
J Med Internet Res 2021;23(7):e27822
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