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Integrating Virtual Reality, Neurofeedback, and Cognitive Behavioral Therapy for Auditory Verbal Hallucinations (Hybrid): Protocol of a Pilot, Unblinded, Single-Arm Interventional Study

Integrating Virtual Reality, Neurofeedback, and Cognitive Behavioral Therapy for Auditory Verbal Hallucinations (Hybrid): Protocol of a Pilot, Unblinded, Single-Arm Interventional Study

First, the efficacy of antipsychotic medication for the treatment of positive symptoms of psychosis is not optimal. For example, while commonly prescribed antipsychotics can be significantly more effective than placebo, these medications are accompanied by side effects such as weight gain, sedation, and extrapyramidal symptoms which lead to high incidences of patient nonadherence [2].

Jessica Spark, Elise Rowe, Mario Alvarez-Jimenez, Imogen Bell, Linda Byrne, Ilvana Dzafic, Carli Ellinghaus, Suzie Lavoie, Jarrad Lum, Brooke McLean, Neil Thomas, Andrew Thompson, Greg Wadley, Thomas Whitford, Stephen Wood, Hok Pan Yuen, Barnaby Nelson

JMIR Res Protoc 2025;14:e63405

Glucagon-Like Peptide-1 Receptor Agonists Combined With Personalized Digital Health Care for the Treatment of Metabolic Syndrome in Adults With Obesity: Retrospective Observational Study

Glucagon-Like Peptide-1 Receptor Agonists Combined With Personalized Digital Health Care for the Treatment of Metabolic Syndrome in Adults With Obesity: Retrospective Observational Study

The program’s “value-based” approach underscores its commitment to efficacy, promising partial refunds to participants who fulfill specified compliance metrics but do not achieve a minimum 10% weight loss within the program’s timeframe. This ensures accountability while prioritizing the participant’s progress and well-being. Hyperpersonalization lies at the core of Zone.Health, where each participant’s unique physiological, behavioral, and psychological profile is considered.

Hala Zakaria, Hadoun Jabri, Sheikha Alshehhi, Milena Caccelli, Joelle Debs, Yousef Said, Joudy Kattan, Noah Almarzooqi, Ali Hashemi, Ihsan Almarzooqi

Interact J Med Res 2025;14:e63079

Multilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study

Multilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study

Outcomes included portal-related outcomes (portal activation [logins during the first month], portal engagement [logins over 6 months], digital health literacy, technology acceptability), health-related outcomes (Hb A1c, T2 D self-management [medication, blood glucose monitoring, healthy eating, and physical activity], and psychosocial function [diabetes self-efficacy, autonomy support, and diabetes distress]).

Robin Whittemore, Sangchoon Jeon, Samuel Akyirem, Helen N C Chen, Joanna Lipson, Maritza Minchala, Julie Wagner

JMIR Form Res 2025;9:e67293

Digital Wellness Programs in the Workplace: Meta-Review

Digital Wellness Programs in the Workplace: Meta-Review

During the full-text screening process, it became clear that the central focus of the literature revolves around the efficacy and acceptability of DWPs. Thus, the initial questions were refined into the following specific research inquiries: What technologies and health domains have been investigated in prior research on DWPs? What do we know about the efficacy and acceptability of DWPs?

Saeed Amirabdolahian, Guy Pare, Stefan Tams

J Med Internet Res 2025;27:e70982

Efficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Patients With Breast Cancer: Protocol for a Randomized Clinical Trial

Efficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Patients With Breast Cancer: Protocol for a Randomized Clinical Trial

The objective of this project is to develop a randomized clinical trial to determine the efficacy of a supervised exercise program on pain, physical function, and quality of life in female patients with cancer. A supervised exercise program reduces pain and improves physical function and quality of life in female patients with cancer compared to a control group not receiving the exercise program.

Jennifer García-Molina, Olalla Saiz-Vázquez, Montserrat Santamaría-Vázquez, Juan Hilario Ortiz-Huerta

JMIR Res Protoc 2025;14:e63891

A Digital Pornography Education Prototype Co-Designed With Young People: Formative Evaluation

A Digital Pornography Education Prototype Co-Designed With Young People: Formative Evaluation

Research is still needed to determine the efficacy and impact of digital pornography literacy resources on young people’s sexual attitudes, beliefs, and behaviors. The findings from this formative evaluation highlight the potential for creating engaging and highly pertinent online platforms for pornographic literacy, specifically tailored to the distinctive requirements of structurally marginalized young people.

Jake Turvey, Michelle Raggatt, Cassandra J C Wright, Angela C Davis, Meredith J Temple-Smith, Megan S C Lim

JMIR Form Res 2025;9:e65859

Evaluation of Comparative Efficacy of Polyherbal Steam Inhalation Versus Polyherbal Nasal Fumigation (Dhoopana) in Children With Rhinitis (Pratishyaya): Protocol for an Open-Label Randomized Controlled Trial

Evaluation of Comparative Efficacy of Polyherbal Steam Inhalation Versus Polyherbal Nasal Fumigation (Dhoopana) in Children With Rhinitis (Pratishyaya): Protocol for an Open-Label Randomized Controlled Trial

The efficacy of steam inhalation of tulsi, vasa, nirgundi, and nilgiri has already been shown in respiratory tract infections [10]. So, in this study, dhoopana of a polyherbal formulation containing tulsi, vasa, nirgundi, and nilgiri will be compared with a steam inhalation containing arka of tulsi, vasa, nirgundi, and nilgiri in pratishyaya in children.

Monika Kakar, Renu Rathi, Deepthi Balakrishnan, Bharat Rathi

JMIR Res Protoc 2025;14:e58197

Virtual Reality Interventions and Chronic Pain: Scoping Review

Virtual Reality Interventions and Chronic Pain: Scoping Review

Chronic pain affects 50 million US adults [1], and treatments have limited long-term efficacy, significant side effects, or limited accessibility [2-5]. As a result of the continuing opioid overdose crisis, numerous clinical and research guidelines have recommended further study of nonpharmacological options [6-8]. Virtual reality (VR) treatments have the potential to immerse participants within a virtual environment to confer health benefits to users.

Michael E Ding, Hajar Traiba, Hector R Perez

J Med Internet Res 2025;27:e59922

Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis

Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis

While many clinical trials have examined the efficacy of MSCs in acute MI treatment, the data collection methods, timing of MSC administration, route of MSC administration, and evaluated end points have been heterogeneous. Several articles representing long-term follow-up of original studies have recently been published, which collectively provide additional insights.

Michael Vincent DiCaro, Brianna Yee, KaChon Lei, Kavita Batra, Buddhadeb Dawn

JMIR Res Protoc 2025;14:e60591