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Given the anticipated overlap of these conditions, ≈20% (n=90) of women will have at least one maternal metabolic disease of interest (secondary outcome).
Study data are collected using paper case report forms. These paper documents will be kept in a locked cupboard accessible only to local research staff. Patient information is collected and stored by the investigators in a confidential REDCap (Research Electronic Data Capture system; Vanderbilt University), with password protection and restricted access.
JMIR Res Protoc 2025;14:e72542
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Characteristics and questionnaire responses from participants (N=60). Quantitative data collected in situation analysis at Chris Hani Baragwanath Academic Hospital and Tembisa Provincial Tertiary Hospital from December 2022 to February 2023.
a Knowledge of post–COVID-19 complications was assessed by asking “Do you know what long-COVID or post-COVID-19 condition is?” and allowing participants to answer yes or no and elaborate on their answer.
JMIR Form Res 2025;9:e58436
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International experts (N=57) identified as leading or established researchers in the field of occupational health (with a specific focus on modification of physical activity [PA] behavior in the workplace), well-being, or computer- or desk-based jobs specialists identified by the research team were invited via email to participate.
JMIR Hum Factors 2025;12:e59405
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A Qualtrics survey was distributed to the YAB, asking respondents to rate and rank potential logos and designs (N=11). The top 3 logos and fonts (determined by average ranking and average rating) were implemented into a second Qualtrics survey (N=9). The highest average ranked combination of logo and font was selected as the official logo of PL4 Y (Figure 2).
JMIR Form Res 2025;9:e60531
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We reviewed 102 surgical pathology reports from 102 patients and excluded reports if they were from other organ sites (n=10), benign (n=2), cytopathology (n=5), or outside review (n=1). We included 84 reports for analysis. The study flowchart is shown in Figure 2.
Flowchart of the study design and analysis. *The concordance rate was calculated as the total number of concordant answers/total number of answers for each of the 12 medical question answering (MQA).
JMIR Form Res 2025;9:e64544
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Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map
A much smaller number of studies (n=6) examined the utility of VR in chronic pain populations including intensive pain rehabilitation (n=1) [112], chronic burn dressing (n=1) [113], chronic musculoskeletal pain (n=1) [114], chronic cancer-related pain (n=2) [115,116], and chronic abdominal pain (n=1) [117]. See Figure 2 for the summary of pain populations included across the studies.
JMIR Pediatr Parent 2025;8:e63854
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The result is n=395.21 for each group, so we set the number of patients to be analyzed to 400 with the AI-powered tool and 400 without the tool.
For time-saving, applying a similar procedure with the same standard values, σ=90 seconds and d=30 seconds, we obtain n=111.15 for each group, so we set the number of consultations to be analyzed to 120 with the AI-powered tool and 120 without the tool.
JMIR Res Protoc 2025;14:e66232
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The planned effectiveness study sample size is 6600 enrolled patients, including approximately 300 (4.56%) from each of the 22 participating clinics (Bronx: n=6, 27%; Indiana: n=16, 73%).
For the implementation interviews, we will use snowball sampling to identify the most relevant informants across clinics of different sizes.
JMIR Res Protoc 2025;14:e60471
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The final study sample size (N=23) also met the recommended sample size guidelines for achieving rigor in qualitative research of this type [18].
The open-ended interview questions (Multimedia Appendix 1), with a caregiver version and a clinician version, were developed by the research team and based on existing literature about the sources of stress and support for parents with babies in the NICU.
JMIR Pediatr Parent 2025;8:e66401
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