TY  - JOUR
AU  - Tang, Wen-Zhen
AU  - Zhu, Sheng-Rui
AU  - Mo, Shu-Tian
AU  - Xie, Yuan-Xi
AU  - Tan, Zheng-Ke-Ke
AU  - Teng, Yan-Juan
AU  - Jia, Kui
PY  - 2025
DA  - 2025/2/27
TI  - Predictive Value of Frailty on Outcomes of Patients With Cirrhosis: Systematic Review and Meta-Analysis
JO  - JMIR Med Inform
SP  - e60683
VL  - 13
KW  - frailty
KW  - cirrhosis
KW  - diagnostic efficiency
KW  - survival
KW  - meta-analysis
KW  - prognostic factor
KW  - systematic review
AB  - Background: Frailty is one of the most common symptoms in patients with cirrhosis. Many researchers have identified it as a prognostic factor for patients with cirrhosis. However, no quantitative meta-analysis has evaluated the prognostic value of frailty in patients with cirrhosis. Objective: This systematic review and meta-analysis aimed to assess the prognostic significance of frailty in patients with cirrhosis. Methods: The systematic review was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations. We conducted a comprehensive search of the literature using databases such as PubMed, Cochrane Library, Embase, and Web of Science, as well as China National Knowledge Infrastructure, encompassing the period from inception to 22 December 2023. Data were extracted for frailty to predict adverse outcomes in patients with cirrhosis. RevMan (version 5.3) and R (version 4.2.2) were used to assess the extracted data. Results: A total of 26 studies with 9597 patients with cirrhosis were included. Compared with patients having low or no frailty, the frail group had a higher mortality rate (relative ratio, RR=2.07, 95% CI 1.82‐2.34, P<.001), higher readmission rate (RR=1.50, 95% CI 1.22‐1.84, P<.001), and lower quality of life (RR=5.78, 95% CI 2.25‐14.82, P<.001). The summary receiver operator characteristic (SROC) curve of frailty for mortality in patients with cirrhosis showed that the false positive rate (FPR) was 0.25 (95% CI 0.17-0.34), diagnostic odds ratio (DOR) was 4.17 (95% CI 2.93-5.93), sensitivity was 0.54 (95% CI 0.39-0.69), and specificity was 0.73 (95% CI 0.64-0.81). The SROC curve of readmission showed that the FPR, DOR, sensitivity, and specificity were 0.39 (95% CI 0.17-0.66), 1.38 (95% CI 0.64-2.93), 0.46 (95% CI 0.28-0.64), and 0.60 (95% CI 0.28-0.85), respectively. Conclusions: This meta-analysis demonstrated that frailty is a reliable prognostic predictor of outcomes in patients with cirrhosis. To enhance the prognosis of patients with cirrhosis, more studies on frailty screening are required. Trial Registration: PROSPERO CRD42024497698; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=497698 
SN  - 2291-9694
UR  - https://medinform.jmir.org/2025/1/e60683
UR  - https://doi.org/10.2196/60683
DO  - 10.2196/60683
ID  - info:doi/10.2196/60683
ER  -