TY  - JOUR
AU  - Yin, Ziming
AU  - Kuang, Zhongling
AU  - Zhang, Haopeng
AU  - Guo, Yu
AU  - Li, Ting
AU  - Wu, Zhengkun
AU  - Wang, Lihua
PY  - 2024
DA  - 2024/6/10
TI  - Explainable AI Method for Tinnitus Diagnosis via Neighbor-Augmented Knowledge Graph and Traditional Chinese Medicine: Development and Validation Study
JO  - JMIR Med Inform
SP  - e57678
VL  - 12
KW  - knowledge graph
KW  - syndrome differentiation
KW  - tinnitus
KW  - traditional Chinese medicine
KW  - explainable
KW  - ear
KW  - audiology
KW  - TCM
KW  - algorithm
KW  - diagnosis
KW  - AI
KW  - artificial intelligence
AB  - Background: Tinnitus diagnosis poses a challenge in otolaryngology owing to an extremely complex pathogenesis, lack of effective objectification methods, and factor-affected diagnosis. There is currently a lack of explainable auxiliary diagnostic tools for tinnitus in clinical practice. Objective: This study aims to develop a diagnostic model using an explainable artificial intelligence (AI) method to address the issue of low accuracy in tinnitus diagnosis. Methods: In this study, a knowledge graph–based tinnitus diagnostic method was developed by combining clinical medical knowledge with electronic medical records. Electronic medical record data from 1267 patients were integrated with traditional Chinese clinical medical knowledge to construct a tinnitus knowledge graph. Subsequently, weights were introduced, which measured patient similarity in the knowledge graph based on mutual information values. Finally, a collaborative neighbor algorithm was proposed, which scored patient similarity to obtain the recommended diagnosis. We conducted 2 group experiments and 1 case derivation to explore the effectiveness of our models and compared the models with state-of-the-art graph algorithms and other explainable machine learning models. Results: The experimental results indicate that the method achieved 99.4% accuracy, 98.5% sensitivity, 99.6% specificity, 98.7% precision, 98.6% F1-score, and 99% area under the receiver operating characteristic curve for the inference of 5 tinnitus subtypes among 253 test patients. Additionally, it demonstrated good interpretability. The topological structure of knowledge graphs provides transparency that can explain the reasons for the similarity between patients. Conclusions: This method provides doctors with a reliable and explainable diagnostic tool that is expected to improve tinnitus diagnosis accuracy. 
SN  - 2291-9694
UR  - https://medinform.jmir.org/2024/1/e57678
UR  - https://doi.org/10.2196/57678
UR  - http://www.ncbi.nlm.nih.gov/pubmed/38857077
DO  - 10.2196/57678
ID  - info:doi/10.2196/57678
ER  -