@Article{info:doi/10.2196/63601,
author="Dai, Pei-Yu
and Lin, Pei-Yi
and Sheu, Ruey-Kai
and Liu, Shu-Fang
and Wu, Yu-Cheng
and Wu, Chieh-Liang
and Chen, Wei-Lin
and Huang, Chien-Chung
and Lin, Guan-Yin
and Chen, Lun-Chi",
title="Predicting Agitation-Sedation Levels in Intensive Care Unit Patients: Development of an Ensemble Model",
journal="JMIR Med Inform",
year="2025",
month="Feb",
day="26",
volume="13",
pages="e63601",
keywords="intensive care units; ICU; agitation; sedation; ensemble learning; machine learning; ML; artificial intelligence; AI; patient safety; efficiency; automation; ICU care; ensemble model; learning model; explanatory analysis",
abstract="Background: Agitation and sedation management is critical in intensive care as it affects patient safety. Traditional nursing assessments suffer from low frequency and subjectivity. Automating these assessments can boost intensive care unit (ICU) efficiency, treatment capacity, and patient safety. Objectives: The aim of this study was to develop a machine-learning based assessment of agitation and sedation. Methods: Using data from the Taichung Veterans General Hospital ICU database (2020), an ensemble learning model was developed for classifying the levels of agitation and sedation. Different ensemble learning model sequences were compared. In addition, an interpretable artificial intelligence approach, SHAP (Shapley additive explanations), was employed for explanatory analysis. Results: With 20 features and 121,303 data points, the random forest model achieved high area under the curve values across all models (sedation classification: 0.97; agitation classification: 0.88). The ensemble learning model enhanced agitation sensitivity (0.82) while maintaining high AUC values across all categories (all >0.82). The model explanations aligned with clinical experience. Conclusions: This study proposes an ICU agitation-sedation assessment automation using machine learning, enhancing efficiency and safety. Ensemble learning improves agitation sensitivity while maintaining accuracy. Real-time monitoring and future digital integration have the potential for advancements in intensive care. ",
issn="2291-9694",
doi="10.2196/63601",
url="https://medinform.jmir.org/2025/1/e63601",
url="https://doi.org/10.2196/63601"
}