The study used a systematic review and qualitative meta-aggregation. The study adheres to the PRISMA (Preferred Report Items for Systematic Review and Meta-Analysis; see Checklist 1) and the Joanna Briggs Institute (JBI) Reviewer’s Manual [36,37]. Meta-aggregation, based on the philosophical traditions of pragmatism and Husserlian transcendental phenomenology, aims to produce generalizable recommendations to guide practitioners and policymakers [37,38].

Inclusion criteria were established for this study according to the PCC (population, content, and context) framework. The population of interest consisted of mothers living with HIV and their health care providers. The content experiences and perspectives toward integrating digital-based interventions into PMTCT of HIV. Studies that reported on both positive and negative experiences and perspectives were included. Context was defined as any type of digital-based intervention (synchronous and asynchronous), such as text messaging, mobile health apps, telemedicine, or internet-based programs.

The exclusion criteria were quantitative studies of articles published in nonpeer-reviewed journals. Conference abstracts, posters, editorials, commentaries, and reviews were excluded. The articles not written in English were excluded. In addition, no date restrictions were applied to ensure the inclusion of all relevant studies regardless of their publication year. All database searches were conducted on July 5, 2024.

A comprehensive search of multiple databases was conducted to identify relevant studies. Scopus, PubMed, Medline, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Wiley Online Library were searched from their inception up to 5 July 2024. The search strategy was developed using a combination of keywords and Medical Subject Headings (MeSH) terms related to digital-based interventions and MTCT of HIV. The search terms used were ([HIV OR “Human Immunodeficiency Virus” OR “Human Immunodeficiency Viruses”] AND [“Digital technology” OR “mobile health” OR mhealth OR ehealth OR telehealth OR telemedicine OR telenursing OR “mobile apps” OR “mobile application”] AND [“medication adherence” OR adherence OR “medication nonadherence” OR “medication compliance” OR “medication noncompliance”]). See Multimedia Appendix 1 for the search strategy. Additional relevant studies were identified through snowballing searches, using the “related articles” feature and the reference lists of the included articles. A total of 2 independent reviewers (SM and ADN) assessed all articles for eligibility, with any discrepancies resolved through consultation with a third reviewer (LNA). Studies were included if they contained original qualitative data on the experiences and perspectives of mothers living with HIV, health care providers, or other relevant stakeholders of digital-based interventions in PMTCT services.

A total of 2 reviewers conducted data extraction independently using a standardized tabulation table. The table included study details such as author and year, study design, country, participant characteristics, model of digital technology, superordinate themes, subordinate themes, and quotes. Reviewers independently evaluated the studies, considering potential sources of bias, the research questions, the appropriateness of methodology, data collection, ethical considerations, rigor, data analysis, and findings. Any discrepancies between the authors were resolved through discussion and consensus.

The quality of the included studies was assessed using the JBI Critical Appraisal tools for qualitative research, and the Mixed Methods Appraisal Tool (MMAT; version 2018) for mixed methods studies [38,39]. The use of both tools was necessary due to the inclusion of qualitative and mixed methods studies. The JBI checklist is designed to evaluate the methodological validity of studies and to determine the extent to which a study has addressed the possibility of bias in its design, conduct, and analysis [38]. The MMAT is a comprehensive tool that allows for the simultaneous appraisal of qualitative, quantitative, and mixed methods studies [39]. It includes criteria tailored to assess the methodological quality of mixed methods research, such as the integration of the qualitative and quantitative components, the coherence between the research question and methodological approach, and the adequacy of the data collection and analysis methods. The authors assigned a total score to each study and divided them into three categories of quality: high (≥75%), some concerns (50%‐74%), and low (≤49%).

Following the JBI Reviewer’s Manual, the study used a 3-step meta-aggregation approach to synthesize qualitative study findings [38]. Initially, 2 reviewers independently and repeatedly analyzed the reports of the selected studies, extracting findings and illustrative examples from the results sections. They identified themes, metaphors, and concepts described by the original authors. The credibility of the findings was then assessed and categorized as unequivocal, credible, or unsupported, based on how well the findings matched their supporting illustrations. Second, the reviewers independently grouped the unequivocal or credible findings into categories based on similar meanings. They discussed any differences and clarified the descriptions of the categories until they reached a consensus. Finally, they created synthesized findings by summarizing the categories that shared common features.

A total of 2063 records were identified through database searches, including Scopus (n=625), PubMed (n=868), CINAHL (n=273), and Wiley Online Library (n=297). After removing 33 duplicates, 2030 records remained for title and abstract screening. Of these, 2009 records were excluded because they did not meet the inclusion criteria (eg, not focused on PMTCT, not HIV-related, not involving digital-based interventions, or not qualitative in design). These records are reported collectively as “not relevant” in the PRISMA flow diagram, resulting in 21 reports identified for full-text retrieval. Among these 21, one study was a registered protocol or rationale paper without complete study findings and therefore excluded from the eligibility assessment. Thus, 20 full-text articles were assessed for eligibility. After full-text review, 13 studies were excluded due to reasons such as reporting outcomes only (n=1), being randomized controlled trials (n=10), and protocol studies (n=2). Consequently, 7 studies met the inclusion criteria and were included in the synthesis. An additional study was identified through snowballing, bringing the total to 8 studies included in the final synthesis. A detailed breakdown of the study selection process and exclusion reasons is presented in the PRISMA flow diagram (see Figure 1) [40-47].

Included studies were diverse in terms of the study design, study location, and digital-based intervention model used. Among the 8 studies included, 3 were qualitative studies [41,43,44] and 5 used mixed methods [40,42,45-47]. The studies were conducted in Kenya, South Africa, and India and aligned with areas with high HIV prevalence. Digital-based interventions evaluated in these studies included mobile SMS, mobile phone calls, and mobile apps. The maternal age distribution of the study participants ranged from 18 to 32 years old. The diversity of study designs and intervention models included provided an understanding of the experiences and perspective toward digital-based interventions that addressed PMTCT of HIV (see Table 1).

Furthermore, the characteristics of the intervention model in the included studies are presented in Table 2. The interventions predominantly used mobile phone technology, including SMS-based messaging, voice calls, and mobile applications. Messaging formats ranged from unidirectional updates to interactive, bidirectional communication, enabling users to engage more actively with the system. Some interventions used group messaging platforms or private phone calls, while others relied on mobile apps specifically designed for maternal and child health support. The content of these interventions varied widely, covering areas such as appointment reminders, early infant diagnosis follow-up, counseling on ART and PMTCT, educational messages on pregnancy, breastfeeding, and disclosure, as well as support for general health and well-being. Many models also incorporated treatment adherence support and emotional or social support mechanisms. These services primarily targeted pregnant, postpartum, and breastfeeding women. They were delivered by a range of providers, including nurses, general practitioners, HIV specialists, nutritionists, trained mentors, and community health workers.

Based on the quality assessment of the included qualitative studies, a study was categorized as “Low” and another 2 were categorized as “Some concerns” (see Multimedia Appendix 2). The analysis revealed that most biases were identified in the research components related to alignment between the research methodology and the question or objectives, methods used to collect data, data analysis, and the interpretation of results.

The MMAT assessment revealed that while all studies clearly stated their research questions and collected sufficient data to address them, several methodological concerns were noted. In particular, the alignment between research questions and methodologies was often weak. The qualitative components showed unclear justification for the chosen approaches, and in the quantitative (nonrandomized and descriptive) components, issues such as limited sample representativeness, potential nonresponse bias, and inadequate statistical analyses were identified. Furthermore, the rationale for adopting a mixed methods design was frequently insufficient, with many studies failing to justify how combining methods addressed their research aims. These findings, detailed in the MMAT assessment matrix (see Multimedia Appendix 2), highlight the need for more rigorous methodological justification, especially in studies using mixed methods designs.

A total of 4 synthesized findings emerged, and 9 categories from 17 findings of this study. Table 3 shows detailed information about findings, categories, and synthesized findings. Multimedia Appendix 3 shows detailed information with original quotes.

This study identified 4 key themes that reflect the experiences and perspectives of mothers living with HIV and health care providers regarding integration of digital-based interventions into PMTCT of HIV services. First, digital interventions were perceived as acceptable, supported by subthemes such as perceived satisfaction, ease of use, usefulness, increased motivation, and improved adherence to care. Second, mothers living with HIV expressed specific needs for education, support systems, and reminders. They desired information about ART side effects, MTCT, and infant prophylaxis. Subthemes also included the importance of peer support groups and timely reminders for clinic visits and medication use. Third, concerns about confidentiality emerged as a barrier, particularly the fear of unintended HIV status disclosure through text messages received in the presence of others. Finally, participants highlighted personal, interpersonal, and health system barriers that hindered digital care adherence. These included a lack of family support, financial hardship, and negative attitudes from health care providers.

The use of digital-based interventions in health care has grown rapidly in recent years, and this study highlights their benefits in promoting adherence to maternal and child health interventions [41-47]. These interventions have increasingly become a critical component of health care delivery, even in resource-limited settings, and are now embedded within modern society [48,49]. Although some mothers living with HIV expressed concerns about confidentiality, this study found that the integration of digital-based interventions into PMTCT of HIV services enhanced their satisfaction with care and supported better adherence to treatment. This suggests the use of digital technology as an effective platform to reach and engage mothers living with HIV and their infants. As suggested previously, a high level of acceptability significantly determines successful linkage to and retention in care [50]. The findings align with the growing body of evidence on the usefulness of mobile technology in enhancing health care services across the HIV care continuum and among key populations [34,51-55].

The health care–related needs of mothers living with HIV, particularly in the context of digital-based interventions, primarily focus on education, support systems, and reminders [41-47]. This study found that mothers expressed a desire for digital-based interventions that provide educational content related to treatment, maternal health, and infant care [41]. These digital platforms can serve as valuable tools by delivering reliable information on health conditions, treatment options, medication usage, and self-care practices, thereby supporting improved health literacy and better health outcomes [56,57]. Empowering mothers with such knowledge enables them to make more informed decisions regarding their own health and that of their children.

Furthermore, mothers living with HIV, who often face complex medical and psychosocial challenges, frequently seek emotional and psychological support [58]. The theme of self-isolation frequently emerged in relation to experiences of HIV-related stigma and coping mechanisms [59]. Digital interventions that include support features, such as online communities, chat groups, or direct messaging with health care professionals can provide emotional support, reduce feelings of isolation, and foster a sense of belonging [60]. However, some participants may avoid participating in peer groups due to concerns about confidentiality.

Although mobile phone–based platforms, as digital-based interventions, were generally acceptable and facilitated care engagement, concerns specifically related to SMS were frequently reported [41,42]. These concerns were primarily driven by fears of unintended HIV status disclosure through visible text messages, particularly in shared phone settings or when notifications appeared on locked screens [41,42]. This contrast highlights that while the device itself was acceptable, the mode of digital communication, such as SMS, may introduce risks that affect trust and usability. Therefore, this is not a contradiction but rather a reflection of how acceptability is influenced by the specific design features of digital interventions.

Retention in care and adherence to treatment and care are essential for effectively managing mothers living with HIV and reducing the risk of vertical transmission through viral suppression [61,62]. In this study, mothers living with HIV frequently expressed the need for digital applications that provide timely reminders for taking and refilling medications, clinic appointments, and daily health routines. Such features can significantly enhance treatment adherence and contribute to improved health outcomes for both mothers living with HIV and their babies [55,63].

Although digital health interventions show promise in improving PMTCT outcomes, this study identified confidentiality as a major concern among mothers living with HIV [41,42]. This concern highlights the critical importance of protecting the privacy and confidentiality of health information for mothers living with HIV, especially their HIV status. This underscores the need for health care systems to protect the privacy of individuals’ health information, particularly HIV status, by implementing robust privacy policies and upholding legal and ethical standards [64]. This includes securing medical records, limiting access to sensitive data, and obtaining informed consent before disclosing health information to others, including family members or partners.

Barriers to treatment, such as lack of family support, financial difficulties, and negative provider attitudes, are critical factors influencing access to and use of digital-based HIV care interventions among mothers living with HIV. Within the context of ANC, regular clinical visits are essential; however, limited family support and financial problems often make it difficult for mothers to undergo HIV testing and access necessary health care services [65]. The cost of transportation and medical services, combined with poverty-related issues such as food insecurity, further hinders treatment adherence [66]. In addition, partner notification and effective couples counseling are essential as an entry point to identify serodiscordant partners, facilitate mutual disclosure of HIV status, and link those living with HIV to appropriate care and treatment services [67].

A strategic approach involves encouraging national HIV program leaders to advocate long-term policy changes that support the home delivery of antiretrovirals [68]. In addition, targeted financial incentives—such as unconditional cash transfers—have been shown to improve access to care and support treatment adherence, including assistance with ART initiation and transportation to health care facilities [66]. To further address economic barriers, livelihood programs and vocational training, such as microcredit initiatives, can empower mothers living with HIV [66].

In addition, provider attitudes and communication styles can significantly influence the willingness of mothers living with HIV to seek health care services. When mothers living with HIV feel judged, disrespected, or misunderstood—whether during in-person visits or digital interactions—they may be hesitant to participate fully in care or may withhold important health information. Cultural competence and empathy are essential for building trust, particularly given the unique vulnerabilities and stigma often experienced by this population [69]. Negative provider attitudes can contribute to disparities in health care access, leading to reduced quality of care and poorer health outcomes for certain patient populations [69]. To address these challenges, health care professionals should receive training in cultural sensitivity, empathetic communication, and care tailored to mothers living with HIV—both in traditional and digital settings—to ensure that integration of digital-based interventions into PMTCT services is delivered in a supportive and inclusive manner [69].

These findings inform the design of future digital-based interventions for PMTCT of HIV by highlighting the importance of tailoring programs to the specific needs and preferences of both mothers living with HIV and health care providers. To address concerns around confidentiality, policies should ensure robust privacy protections, grounded in the ethical and legal standards of nursing and other health care professions [64]. In addition, government regulations should establish clear guidelines for evaluating the effectiveness and impact of digital health practice [70]. In addition, the national HIV program should consider implementing home delivery of antiretrovirals to address financial barriers. In addition, providing financial incentives to improve linkage to ANC and early infant diagnosis (EID), particularly among low-income populations [71,72], such as covering mobile data costs and offering transportation support for facility visits when ANC or EID is required.

Furthermore, international financial support has played a crucial role in advancing digital-based intervention for HIV care, including PMTCT initiatives. These contributions have supported progress in reducing new HIV infections and lowering maternal and infant mortality related to HIV. However, several major donor countries have announced substantial cuts to their aid budgets for the 2025‐2026 period. This financial shift may jeopardize the sustainability of PMTCT programs, particularly in low-resource settings. Strategic investment in digital infrastructure is therefore essential to maintaining momentum toward achieving global health targets, especially in remote and underserved areas. The rapid expansion of mobile and communication technologies in LMICs presents an opportunity to optimize service delivery. Digital platforms, such as eHealth and mHealth, can support timely counseling, treatment adherence, follow-up, and remote monitoring for mothers living with HIV and their infants through SMS, video consultations, or online check-ins. Strengthening these systems aligns directly with Sustainable Development Goal 3, which aims to ensure healthy lives and promote well-being for all, including ending the HIV/AIDS epidemic and improving maternal and child health outcomes.

To enhance feasibility, delivery models for PMTCT digital interventions must be tailored to local digital infrastructures and user contexts, ensuring they integrate seamlessly with existing care pathways and uphold privacy standards. In low-connectivity settings, voice calls and SMS reminders offer widely accessible options, while in higher-connectivity areas, smartphone-based tools like apps or chatbots can support more interactive counseling, peer support, and data reporting [73]. These digital platforms should be interoperable with national health information systems to monitor ANC, ART adherence, and EID outcomes. Equitable implementation also demands backup delivery modes, for instance, offering SMS as an alternative for users without smartphones.

Despite the valuable insights offered by this study, several limitations must be acknowledged to provide a balanced interpretation of the findings. First, methodological limitations were evident in the included studies, particularly regarding the alignment between philosophical underpinnings and research design. Many studies did not explicitly state the researcher’s cultural or theoretical positioning, nor did they reflect on how the researcher may have influenced or been influenced by the research process—an important element in qualitative rigor [74] . Second, the scope of this study was limited to 4 electronic databases (eg, Scopus, PubMed, CINAHL, and Wiley), which may have resulted in the omission of relevant studies published elsewhere, including in scientific search engines (eg, Google Scholar and ScienceDirect) and in the gray literature. This limitation may reduce the comprehensiveness and inclusivity of the synthesized evidence. However, to minimize publication and selection bias, we supplemented our search with manual hand-searching [75,76]. Third, this study included only studies published in English, which may have excluded relevant evidence from non-English sources and introduced language bias.

Fourth, in some themes, the synthesis was informed by only a single primary study, which weakens the transferability and generalizability of the findings. Conclusions drawn from a single context are less robust and may not be applicable across diverse populations or settings. Fifth, considerable variation was observed in the types of digital technologies reported across studies, which may contribute to heterogeneity in outcomes. These differences, ranging from SMS reminders to mobile health apps, can impact the consistency and reliability of the synthesized conclusions. Sixth, the search strategy did not fully use database-specific indexing terms such as PubMed MeSH headings; although MeSH terms were consulted to inform keyword development, reliance on title and abstract keyword searches may have increased the risk of missing relevant studies.

Most interventions in the included studies relied on mobile phone text (SMS) and voice-call technologies. However, 2 SMS-based studies were rated as moderate or lower in quality [41,43], which may introduce potential bias in findings related to SMS delivery models. Also, advanced digital tools were less frequently used and may present different acceptability, usability, and concern profiles compared to simpler technologies. In addition, the barriers identified regarding the integration of digital-based interventions into PMTCT services were predominantly contextual rather than technical in nature. Rather than focusing on usability or platform-specific issues, the findings revealed broader systemic challenges related to the integration of digital interventions into existing health care services. Furthermore, few studies provided technical specifications about the mobile phones used, such as device types, operating systems, or internet requirements. This lack of detail limits our ability to assess disparities in access, particularly in low-resource settings where smartphone ownership, digital literacy, and mobile network coverage are often constrained. These factors should be explored in future research to strengthen the applicability of digital-based interventions for PMTCT of HIV in diverse and underserved contexts.

Findings from this study indicate that digital-based interventions, particularly mobile-based technologies, are highly acceptable among mothers living with HIV and effectively support adherence to PMTCT-related services. Mothers living with HIV valued digital tools for delivering education, emotional support, and appointments or medication reminders. However, concerns regarding confidentiality and barriers such as limited family support, financial constraints, and provider attitudes were identified as significant challenges to digital intervention uptake. To improve PMTCT outcomes in HIV, future digital strategies must prioritize confidentiality, address women’s expressed needs, and consider structural barriers.