<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="review-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMI</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Med Inform</journal-id>
      <journal-title>JMIR Medical Informatics</journal-title>
      <issn pub-type="epub">2291-9694</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v12i1e46699</article-id>
      <article-id pub-id-type="pmid">38477979</article-id>
      <article-id pub-id-type="doi">10.2196/46699</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>The Key Digital Tool Features of Complex Telehealth Interventions Used for Type 2 Diabetes Self-Management and Monitoring With Health Professional Involvement: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Castonguay</surname>
            <given-names>Alexandre</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Kurniawan</surname>
            <given-names>Moh Heri</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Mungoli</surname>
            <given-names>Neelesh</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Ross</surname>
            <given-names>Jamie</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Mannoubi</surname>
            <given-names>Choumous</given-names>
          </name>
          <degrees>RDT, MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>School of Rehabilitation</institution>
            <institution>Université de Montréal</institution>
            <addr-line>7077, avenue du Parc</addr-line>
            <addr-line>Montreal, QC, H3N 1X7</addr-line>
            <country>Canada</country>
            <phone>1 5143436111</phone>
            <email>cmannoubi@gmail.com</email>
          </address>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1145-1531</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Kairy</surname>
            <given-names>Dahlia</given-names>
          </name>
          <degrees>PT, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6872-6607</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Menezes</surname>
            <given-names>Karla Vanessa</given-names>
          </name>
          <degrees>PT, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-2314-1765</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Desroches</surname>
            <given-names>Sophie</given-names>
          </name>
          <degrees>RD, PhD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <xref rid="aff5" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-0797-605X</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Layani</surname>
            <given-names>Geraldine</given-names>
          </name>
          <degrees>MSc, MD</degrees>
          <xref rid="aff6" ref-type="aff">6</xref>
          <xref rid="aff7" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1764-6433</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Vachon</surname>
            <given-names>Brigitte</given-names>
          </name>
          <degrees>OTR, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff8" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-2899-2120</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>School of Rehabilitation</institution>
        <institution>Université de Montréal</institution>
        <addr-line>Montreal, QC</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Centre interdisciplinaire en readaptation du Montreal Métropolitain</institution>
        <institution>Institut Universitaire sur la readaptation en déficience physique de Montreal</institution>
        <addr-line>Montréal, QC</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Institute of Nutrition and Functional Foods</institution>
        <institution>Université Laval</institution>
        <addr-line>Quebec, QC</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Centre nutrition, santé et société NUTRISS</institution>
        <institution>Université Laval</institution>
        <addr-line>Québec, QC</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff5">
        <label>5</label>
        <institution>School of Nutrition</institution>
        <institution>Université Laval</institution>
        <addr-line>Québec, QC</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff6">
        <label>6</label>
        <institution>Centre de recherche du centre hospitalier de l'universite de Montreal</institution>
        <addr-line>Montréal, QC</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff7">
        <label>7</label>
        <institution>Département de médecine de famille et de médecine d’urgence</institution>
        <institution>Universté de Montréal</institution>
        <addr-line>Montreal, QC</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff8">
        <label>8</label>
        <institution>Centre de recherche de l’Institut universitaire en santé mentale de Montréal</institution>
        <institution>Centre integre de sante et de services sociaux de l'Est-de-l'ile-de-Montreal</institution>
        <addr-line>Montréal, QC</addr-line>
        <country>Canada</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Choumous Mannoubi <email>cmannoubi@gmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2024</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>13</day>
        <month>3</month>
        <year>2024</year>
      </pub-date>
      <volume>12</volume>
      <elocation-id>e46699</elocation-id>
      <history>
        <date date-type="received">
          <day>10</day>
          <month>3</month>
          <year>2023</year>
        </date>
        <date date-type="rev-request">
          <day>3</day>
          <month>5</month>
          <year>2023</year>
        </date>
        <date date-type="rev-recd">
          <day>21</day>
          <month>9</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>7</day>
          <month>12</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Choumous Mannoubi, Dahlia Kairy, Karla Vanessa Menezes, Sophie Desroches, Geraldine Layani, Brigitte Vachon. Originally published in JMIR Medical Informatics (https://medinform.jmir.org), 13.03.2024.</copyright-statement>
      <copyright-year>2024</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Informatics, is properly cited. The complete bibliographic information, a link to the original publication on https://medinform.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://medinform.jmir.org/2024/1/e46699" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Therapeutic education and patient self-management are crucial in diabetes prevention and treatment. Improving diabetes self-management requires multidisciplinary team intervention, nutrition education that facilitates self-management, informed decision-making, and the organization and delivery of appropriate health care services. The emergence of telehealth services has provided the public with various tools for educating themselves and for evaluating, monitoring, and improving their health and nutrition-related behaviors. Combining health technologies with clinical expertise, social support, and health professional involvement could help persons living with diabetes improve their disease self-management skills and prevent its long-term consequences.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This scoping review’s primary objective was to identify the key digital tool features of complex telehealth interventions used for type 2 diabetes or prediabetes self-management and monitoring with health professional involvement that help improve health outcomes. A secondary objective was to identify how these key features are developed and combined.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A 5-step scoping review methodology was used to map relevant literature published between January 1, 2010 and March 31, 2022. Electronic searches were performed in the MEDLINE, CINAHL, and Embase databases. The searches were limited to scientific publications in English and French that either described the conceptual development of a complex telehealth intervention that combined self-management and monitoring with health professional involvement or evaluated its effects on the therapeutic management of patients with type 2 diabetes or prediabetes. Three reviewers independently identified the articles and extracted the data.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>The results of 42 studies on complex telehealth interventions combining diabetes self-management and monitoring with the involvement of at least 1 health professional were synthesized. The health professionals participating in these studies were physicians, dietitians, nurses, and psychologists. The digital tools involved were smartphone apps or web-based interfaces that could be used with medical devices. We classified the features of these technologies into eight categories, depending on the intervention objective: (1) monitoring of glycemia levels, (2) physical activity monitoring, (3) medication monitoring, (4) diet monitoring, (5) therapeutic education, (6) health professional support, (7) other health data monitoring, and (8) health care management. The patient-logged data revealed behavior patterns that should be modified to improve health outcomes. These technologies, used with health professional involvement, patient self-management, and therapeutic education, translate into better control of glycemia levels and the adoption of healthier lifestyles. Likewise, they seem to improve monitoring by health professionals and foster multidisciplinary collaboration through data sharing and the development of more concise automatically generated reports.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>This scoping review synthesizes multiple studies that describe the development and evaluation of complex telehealth interventions used in combination with health professional support. It suggests that combining different digital tools that incorporate diabetes self-management and monitoring features with a health professional’s advice and interaction results in more effective interventions and outcomes.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>telehealth</kwd>
        <kwd>telemedicine</kwd>
        <kwd>telenutrition</kwd>
        <kwd>telemonitoring</kwd>
        <kwd>electronic coaching</kwd>
        <kwd>e-coaching</kwd>
        <kwd>scoping review</kwd>
        <kwd>type 2 diabetes</kwd>
        <kwd>prediabetes</kwd>
        <kwd>diabetes management</kwd>
        <kwd>diabetes self-management</kwd>
        <kwd>mobile phone</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Diabetes and Nutrition</title>
        <p>The prevalence of diabetes in Canada is constantly rising, and related health expenditures are among the highest in the world. In 2018, approximately 8% of the Canadian population was living with this disease, and it is predicted that in 2025, a total of 5 million people will be affected (ie, 12.1% of the population) [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. According to estimates, type 2 diabetes accounts for 90% of all diabetes diagnoses in the general population, type 1 diabetes accounts for 9%, and other kinds of diabetes account for 1% [<xref ref-type="bibr" rid="ref3">3</xref>]. The prevalence of diabetes has been closely linked to dietary and lifestyle factors prevalent within the country, such as high rates of obesity and sedentary behavior coupled with a diet often rich in processed foods. However, best practice guidelines suggest that the onset of type 2 diabetes can be delayed or prevented using early lifestyle change interventions. As prediabetes is characterized by elevated blood glucose levels that do not yet meet the diagnostic criteria for diabetes, the therapeutic management of diabetes and prediabetes is similar [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. In both cases, a comprehensive approach is required to better control glycemia levels [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. Many factors are involved in preventing the disease and achieving better disease control, such as changing lifestyles through education, supporting self-management, and preventing the development and progression of complications [<xref ref-type="bibr" rid="ref8">8</xref>]. The Diabetes Canada clinical practice guidelines recommend that individuals with diabetes receive personalized nutrition counseling by a registered dietitian to optimize glycemic control and weight management [<xref ref-type="bibr" rid="ref3">3</xref>]. Strategies include caloric reduction for individuals who are overweight; the incorporation of low glycemic index carbohydrates; and the adoption of a Mediterranean, Nordic, Dietary Approaches to Stop Hypertension (DASH), or vegetarian diet because they are rich in protective foods [<xref ref-type="bibr" rid="ref3">3</xref>]. These interventions are supported by evidence demonstrating improvements in glycated hemoglobin (HbA<sub>1c</sub>) levels, metabolic outcomes, and reductions in hospitalization rates. As stated in the Diabetes Canada clinical practice guidelines, the care offered should be organized around the needs of people with diabetes (and of their families and close friends) because patients must be active participants for optimal engagement in self-managing their condition [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. This active patient participation must be facilitated by a multidisciplinary team (nurses, dietitians, and physicians) that offers education and self-management support. Changing dietary behaviors poses a considerable challenge for people living with diabetes, yet it is a vital means of preventing the associated complications [<xref ref-type="bibr" rid="ref4">4</xref>]. Monitoring with a dietitian’s involvement has proven effective in supporting such behavior changes [<xref ref-type="bibr" rid="ref4">4</xref>]. Again according to the Diabetes Canada clinical practice guidelines, all people living with diabetes should receive the services of a dietitian [<xref ref-type="bibr" rid="ref4">4</xref>]. It has been shown that diet monitoring with a dietitian’s involvement can alone reduce HbA<sub>1c</sub> levels by 1% to 2% [<xref ref-type="bibr" rid="ref4">4</xref>]. In addition, recent evidence underscores the advantages of using telehealth to foster adherence to medical recommendations and self-management [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. Scientific literature has shown the benefits of telehealth in Canada for diabetes management [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. These technological innovations facilitate patient monitoring and promote the use of different interventions that can support lifestyle changes through, for example, remote support, the telemonitoring of glycemia levels, reminders about taking medication, and the use of a food diary. These innovations also allow this information to be shared with the health care team. In 2018, the Diabetes Canada clinical practice guidelines advocated for the use of telehealth in disease management programs to improve self-management in underserved communities and to facilitate consultation with specialized teams, highlighting its effectiveness and the importance of integrating it into shared care models [<xref ref-type="bibr" rid="ref3">3</xref>].</p>
      </sec>
      <sec>
        <title>Telehealth and Diabetes Self-Management</title>
        <p>Telehealth refers to “the use of communications and information technology to deliver health and health care services and information over large and small distances” [<xref ref-type="bibr" rid="ref11">11</xref>]<italic>.</italic> In the same field of application, telemedicine refers to the exchange of medical information using information and communication technologies to improve a patient’s health condition and is delivered by at least 1 health professional [<xref ref-type="bibr" rid="ref12">12</xref>]. Telemedicine services are provided using various means, including the telephone, internet, email, mobile apps, SMS text messaging, photographs, and videos. New technologies are revolutionizing the health care field by creating new prospects for various care delivery modalities [<xref ref-type="bibr" rid="ref13">13</xref>]. They are thus paving the way for innovations and represent a real benefit in the face of new health care challenges, such as the aging population, rising health care costs, and the unprecedented challenges posed by pandemics such as the COVID-19 pandemic [<xref ref-type="bibr" rid="ref6">6</xref>]. Particularly in Canada, the public health care system faces challenges often associated with overcrowded clinics, long wait times, and limited resources [<xref ref-type="bibr" rid="ref7">7</xref>]. Through remote consultations and continuous monitoring, telehealth has the potential to relieve pressure on health care facilities, improving resource allocation and optimizing patient flow management in the public health care system. As such, telehealth would be a pertinent response to public health organizational challenges in the Canadian context, where the universal health care system aims to provide equitable and accessible care to all residents.</p>
        <p>The day-to-day management of type 2 diabetes can be a complex challenge. Patients must monitor their blood glucose levels regularly, take medication on a precise schedule, adopt a balanced diet, and maintain adequate physical activity [<xref ref-type="bibr" rid="ref7">7</xref>]. However, these requirements can be difficult to meet owing to time constraints, a lack of knowledge, or limited resources. In addition, fluctuations in blood glucose levels can occur unpredictably, increasing the risk of short- and long-term complications [<xref ref-type="bibr" rid="ref7">7</xref>]. In particular, nutrition plays a fundamental role in diabetes management. Dietary monitoring, nutrition education, and the personalization of dietary recommendations are key aspects in optimizing health outcomes for patients with diabetes. Using digital technologies, it is possible to offer ongoing personalized nutrition support, enabling patients to make informed dietary decisions and maintain adequate glycemic control.</p>
        <p>Recent evidence points to the enormous potential of using health technologies to facilitate access to care, patient adherence to their treatment plan, and self-management [<xref ref-type="bibr" rid="ref14">14</xref>]. Many experts point out that diabetes is a chronic disease best adapted to self-management through telehealth [<xref ref-type="bibr" rid="ref14">14</xref>-<xref ref-type="bibr" rid="ref19">19</xref>]. Technological innovations have been developed to support lifestyle changes and facilitate patient monitoring. Telehealth offers a range of potential benefits for people with type 2 diabetes. Continuous monitoring of blood glucose levels using connected sensors enables patients to receive real-time information on their blood glucose levels and be alerted to abnormal variations [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. This enables them to take immediate action to correct blood glucose levels and avoid complications. In addition, telehealth facilitates access to specialized care by enabling patients to consult health professionals remotely. This reduces geographic barriers and enables patients to receive personalized advice, education, and support tailored to their specific needs [<xref ref-type="bibr" rid="ref9">9</xref>]. Regular monitoring and feedback as well as the use of digital tools encourage patients to better understand their condition, make informed decisions, and improve their quality of life [<xref ref-type="bibr" rid="ref8">8</xref>]. According to recent systematic reviews and meta-analyses, these telehealth interventions involving everyday web-based and mobile technologies help reduce HbA<sub>1c</sub> levels, allow for better daily glycemic control, promote an increase in physical activity, and improve dietary habits [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>]. Connected blood glucose meters enable more convenient and accurate monitoring of blood glucose levels, whereas web-based platforms offer a web-based space for education, support, and communication with health professionals [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. Teleconsultation enables patients to consult their physicians and specialists remotely, reducing travel and time constraints [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>].</p>
        <p>Combining self-management technologies with clinical expertise, social support, and health professional involvement can allow the development of telehealth solutions better adapted to the therapeutic management of patients with a chronic disease. Telehealth interventions using this combination are therefore expanding [<xref ref-type="bibr" rid="ref22">22</xref>], but they present both advantages and limitations [<xref ref-type="bibr" rid="ref12">12</xref>]. Telehealth enables improved care coordination, personalized interventions, and tailored patient education. However, it can lead to an increased workload for health care providers and raise data privacy concerns. The tension between interventions focused on service delivery and those involving health care providers highlights the importance of striking a balance between patient autonomy and medical expertise. An integrated collaborative approach involving both patients and health care providers may offer the best digital health outcomes. However, further studies are needed to fill the gaps in the literature, focusing on comparative studies with usual care, the evaluation of adherence, and long-term accessibility to optimize the use of telehealth in the self-management of type 2 diabetes.</p>
        <p>To the best of our knowledge, no literature review has been conducted to identify the key digital tool features of such interventions. Nonetheless, improving knowledge on this subject could advance the development of more effective telehealth interventions for people with diabetes.</p>
        <p>The primary objective of this scoping review was to identify the key digital tool features of complex telehealth interventions used for diabetes self-management and monitoring with health professional involvement that help improve health outcomes. The secondary objective was to identify how these key features should be developed and combined to optimize their contribution to improving health outcomes. Although our review draws from global scientific literature, the intent is to inform the future development of telehealth technologies, with a particular emphasis on the Canadian health care context. This focus stems from the recognition that although universal principles may guide the development of digital health tools, the specific features and their implementation must be tailored to meet the unique needs, regulations, and health care infrastructure of Canada. Our review aims to explicitly identify the characteristics of digital tools that have been shown to be effective in improving patient engagement, improving self-management, and leading to better health outcomes in diabetes care. By systematically cataloging these characteristics, we can provide a model for the design, development, and implementation of future telehealth interventions, provided we keep in mind specific requirements of the Canadian health care context, such as compliance with telehealth policies, local health care, patient privacy laws, and existing health IT infrastructure. In this study, <italic>improving health outcomes</italic> encompasses both the positive effects of the intervention on behavior changes (eg, eating healthier foods or performing physical activity) and the positive impacts on the health condition (eg, improved blood glucose levels or blood pressure).</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Overview</title>
        <p>Scoping reviews exhaustively synthesize the evidence to map a vast, complex, or emerging field of study and identify gaps in the literature, ultimately highlighting priorities for future studies in the field [<xref ref-type="bibr" rid="ref23">23</xref>]. We chose this method because telehealth has emerged in different formats and offers solutions to various pathologies. We structured our scoping review according to the five steps developed by Arksey and O’Malley [<xref ref-type="bibr" rid="ref24">24</xref>] and the revisions made by Levac et al [<xref ref-type="bibr" rid="ref25">25</xref>]: (1) identifying the research question; (2) identifying relevant studies; (3) selecting the studies; (4) charting the data; and (5) collating, summarizing, and reporting the results. The procedure, which is described in the following subsections, was conducted in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>) to ensure rigorous and transparent reporting of the methodology and findings [<xref ref-type="bibr" rid="ref26">26</xref>]. Several additional recommendations made by Levac et al [<xref ref-type="bibr" rid="ref25">25</xref>] were also followed: clearly articulate the research question for the scoping review, have 2 researchers independently review the full articles to determine their inclusion, have the research team collectively develop the data-charting form, and continually extract data.</p>
      </sec>
      <sec>
        <title>Identifying the Research Questions</title>
        <p>This review seeks to answer the following research questions:</p>
        <list list-type="order">
          <list-item>
            <p>What are the key digital tool features of complex telehealth interventions used for diabetes self-management and monitoring with health professional involvement that help improve health outcomes?</p>
          </list-item>
          <list-item>
            <p>How should these key features be developed and combined to help improve health outcomes?</p>
          </list-item>
        </list>
        <p>These questions stem from the lack of consensus in scientific literature on the conceptual development, implementation, and evaluation of telehealth solutions. The research questions and objectives were developed based on the research team’s expertise and a preliminary analysis of the literature on the subject. In accordance with scoping review methodology, this review included studies that used different approaches and research designs.</p>
        <p>In this review, we applied the World Health Organization definition of telemedicine: “The delivery of health care services, where distance is a critical factor, by all health professionals using information and communication technologies for the exchange of valid information for diagnosis, treatment and prevention of disease and injuries, research and evaluation, and for the continuing education of health care providers, all in the interests of advancing the health of individuals and their communities.” Furthermore, in the context of telehealth technology, the term <italic>features</italic> refers to the various components or tools that enable the various activities associated with remote health care delivery.</p>
      </sec>
      <sec>
        <title>Identifying and Selecting the Studies</title>
        <p>The search strategy was developed in collaboration with a Université de Montréal librarian specializing in health. The keywords based on <italic>telehealth</italic>, <italic>nutrition</italic>, and <italic>diabetes</italic> were identified by examining relevant articles, their references, and the associated keywords (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>). A systematic search was performed in the MEDLINE, CINAHL, and Embase databases, covering the period from January1, 2010, to March 31, 2022. Our search efforts were focused on these databases because they are repositories where studies related to health and nutrition can be found. Only articles published since January 1, 2010, were selected to account for the widespread adoption of smartphones. By extending our review to cover more than a decade, we were able to capture the significant developments in mobile apps and smartphone use, which are pivotal in digital health. We also perused the bibliographies of the included articles to identify any additional studies. Only articles published in peer-reviewed scientific journals were examined. As proposed by the framework developed by Arksey and O’Malley [<xref ref-type="bibr" rid="ref24">24</xref>], a quality assessment was not performed because it is not deemed essential for exploratory studies. The methodological rigor of the published articles was not an inclusion or exclusion criterion; instead, the articles were examined to substantiate the results and the discussion.</p>
        <p>Given the rapid development of new technologies, only articles on complex telehealth interventions for managing diabetes published in the 12 years covering the period from January 1, 2010, to March 31, 2022, were retained. We used an iterative process to develop the inclusion and exclusion criteria during our searches to ensure a selection of studies more closely aligned with the research question. The searches were limited to scientific publications in English and French that either described the conceptual development of a complex telehealth intervention combining self-management and monitoring with health professional involvement or evaluated its effects on the therapeutic management of patients with type 2 diabetes or prediabetes. For inclusion in this review, the complex interventions had to be digital, have a patient interface, and concern type 2 diabetes or prediabetes self-management or monitoring. We excluded studies (1) not using a nutritional approach to investigate telehealth interventions, (2) involving a single component, (3) not integrating at least 1 health professional, (4) concerning type 1 diabetes or gestational diabetes, (5) involving populations aged &#60;18 years, and (6) lacking empirical data (eg, literature reviews). All search results were imported into the Covidence reference management software (Veritas Health Innovation Ltd), and duplicates were removed [<xref ref-type="bibr" rid="ref27">27</xref>].</p>
        <p>The review team comprised CM, DG, KVM, and BV. These 4 researchers determined the inclusion of relevant studies based on the title and abstract; CM and BV determined the selection based on the full-text articles. Differences were discussed in detail until a consensus was reached. The full texts of the relevant articles were retrieved for more in-depth analysis (CM).</p>
      </sec>
      <sec>
        <title>Charting the Data</title>
        <p>The research team developed a data extraction table. It included the following information: study characteristics (eg, title, participants, the results of interest, and effectiveness), intervention characteristics (eg, a brief description of the intervention, the components of self-management, and the components of monitoring with health professional involvement), and the benefits and limitations of both the intervention and the study according to the authors or reviewers.</p>
      </sec>
      <sec>
        <title>Collecting, Summarizing, and Reporting the Results</title>
        <p>Again according to the framework developed by Arksey and O’Malley [<xref ref-type="bibr" rid="ref24">24</xref>] and the revisions by Levac et al [<xref ref-type="bibr" rid="ref25">25</xref>], descriptive web-based abstracts and thematic analyses performed with NVivo software (release 1.7; Lumivero) were used for data analysis, yielding an approach resembling that of a narrative review. In conducting our thematic analysis, we adopted a qualitative approach to discern the impact of telehealth interventions with health professionals on the health outcomes of patients with diabetes. Through meticulous data immersion and iterative coding, we identified recurring patterns that we then shaped into themes. An initial list of these codes, forming a codebook, was iteratively refined during the data analysis process [<xref ref-type="bibr" rid="ref28">28</xref>]. Once the codes were established, it enabled a comprehensive review of their interrelationships, aiding in the identification of the key digital tool features of complex telehealth interventions used for diabetes self-management and monitoring with health professional involvement that help improve health outcomes. These themes were refined against the data set to ensure coherence and direct relation to our research objectives. By integrating concrete examples from the data, we were able to provide a rich, detailed description of the telehealth features, thereby adding depth to our findings and ensuring that they were both representative of real-world practices and aligned with our research questions.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Overview</title>
        <p>The database searches identified 3755 articles, from which 995 (26.5%) duplicates were removed. The 2760 remaining articles underwent an initial screening based on the abstract and title, after which 2313 (83.8%) were excluded. The full-text screening involved assessing 447 articles, of which 406 (90.8%) were deemed ineligible because the studies did not meet the inclusion criteria (n=258, 63.7%); were literature reviews, editorials, or letters (n=141, 34.8%); or the full texts were inaccessible (n=7, 1.7%; <xref rid="figure1" ref-type="fig">Figure 1</xref>). Thus, of the 3755 articles identified from the database searches, 42 (1.12%) were ultimately included in this scoping review (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref70">70</xref>]). The qualitative analysis of the 42 articles using NVivo (release 1.7) yielded the coding of 1520 references, divided among 113 codes.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Flow diagram of study selection.</p>
          </caption>
          <graphic xlink:href="medinform_v12i1e46699_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Characteristics of the Studies</title>
        <p>The 42 studies were published between January 1, 2010, and March 31, 2022, with as many as 28 (67%) published within the past 6 years [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref56">56</xref>]. We found that, in 2021, nearly twice as many articles were published on the topic as in each of the previous 4 years (<xref rid="figure2" ref-type="fig">Figure 2</xref>).</p>
        <p>Information on complex telehealth interventions used for diabetes self-management and monitoring with health professional involvement was obtained for 18 countries. Of the 42 studies, 11 (26%) were conducted in the United States [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref59">59</xref>]; 5 (12%) in South Korea [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]; 4 (10%) in Singapore [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]; 4 (10%) in Norway [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]; 3 (7%) in the United Kingdom [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>]; 3 (7%) in Germany [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]; 2 (5%) in China [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]; and 1 (2%) each in Australia [<xref ref-type="bibr" rid="ref54">54</xref>], South Africa [<xref ref-type="bibr" rid="ref65">65</xref>], Spain [<xref ref-type="bibr" rid="ref66">66</xref>], Iran [<xref ref-type="bibr" rid="ref52">52</xref>], Italy [<xref ref-type="bibr" rid="ref67">67</xref>], Japan [<xref ref-type="bibr" rid="ref42">42</xref>], Lebanon [<xref ref-type="bibr" rid="ref34">34</xref>], Slovenia [<xref ref-type="bibr" rid="ref36">36</xref>], Switzerland, and Taiwan [<xref ref-type="bibr" rid="ref68">68</xref>] (<xref rid="figure3" ref-type="fig">Figure 3</xref>).</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Years in which the studies were published. Each circle represents 1 study.</p>
          </caption>
          <graphic xlink:href="medinform_v12i1e46699_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <fig id="figure3" position="float">
          <label>Figure 3</label>
          <caption>
            <p>Countries in which the studies were published. The dots represent articles and the x-axis denotes the years.</p>
          </caption>
          <graphic xlink:href="medinform_v12i1e46699_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>General Characteristics of the Intervention</title>
        <p>One-third (14/42, 33%) of the studies were randomized controlled trials [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref67">67</xref>], with most of them (n=12, 86%) ranging from 6 months to 1 year in duration. Of the 42 studies, 9 (21%) were feasibility studies, with the interventions ranging from 3 months to 1 year in duration [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]; 8 (19%) were interventional studies, with the interventions ranging from 3 to 18 months in duration [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]; 5 (12%) were conceptual studies lasting 6 months [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]; and 4 (10%) were pre-post studies, in which the interventions ranged from 1 month to 1 year in duration [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>] (<xref rid="figure4" ref-type="fig">Figure 4</xref>).</p>
        <fig id="figure4" position="float">
          <label>Figure 4</label>
          <caption>
            <p>Durations of the interventions. RCT: randomized controlled trial.</p>
          </caption>
          <graphic xlink:href="medinform_v12i1e46699_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Health Professional Involvement</title>
        <p>Of the 42 studies, 21 (50%) included physicians [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], 16 (38%) involved dietitians [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>-<xref ref-type="bibr" rid="ref70">70</xref>, <xref ref-type="bibr" rid="ref72">72</xref>], 12 (29%) involved nurses [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref58">58</xref>-<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], 4 (10%) involved psychologists [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], 4 (10%) involved physical educators [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], and 3 (7%) involved case managers [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. Finally, of the 42 studies, 13 (31%) involved a multidisciplinary team [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref58">58</xref>-<xref ref-type="bibr" rid="ref60">60</xref>, <xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref72">72</xref>], and 22 (52%) involved only 1 clinician [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref70">70</xref>] (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref> [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref70">70</xref>]).</p>
      </sec>
      <sec>
        <title>Characteristics of Digital Self-Management</title>
        <p>The interventions under study involved the use of a mobile app [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>-<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>-<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>] or a web portal [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>], usually coupled with a blood glucose meter to optimize diabetes self-management [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>-<xref ref-type="bibr" rid="ref64">64</xref>, <xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. Other Bluetooth-connected devices were used in some of the interventions (10/42, 24%), such as a Bluetooth-connected weight scale [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>], a pedometer [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>], an accelerometer [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], a Bluetooth-connected smartwatch [<xref ref-type="bibr" rid="ref49">49</xref>], and a tensiometer [<xref ref-type="bibr" rid="ref42">42</xref>].</p>
        <p>The types of data collected concerned the monitoring of glycemia levels through, for example, the visualization of a blood sugar curve over time [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>-<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>, <xref ref-type="bibr" rid="ref59">59</xref>-<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]; physical activity monitoring using, for example, a pedometer [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]; diet monitoring using, for example, a food diary [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>, <xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref69">69</xref>]; medication monitoring through, for example, adherence monitoring or the possibility of issuing remote prescriptions [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]; and other health data monitoring (weight, BMI, and laboratory tests) [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]. Other features made it possible to ensure continuity of care by, for example, generating reports [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]; supporting therapeutic patient education; and ensuring support from a health professional to help patients learn and develop skills to independently manage their chronic disease and improve their quality of life [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>].</p>
        <p>On the basis of our analysis of the literature, we classified the key digital tool features that can have a positive impact on intervention outcomes into eight categories: (1) monitoring of glycemia levels, (2) diet monitoring, (3) physical activity monitoring, (4) medication monitoring, (5) therapeutic education, (6) health professional support, (7) other health data monitoring, and (8) health care management (<xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref> [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref70">70</xref>]).</p>
      </sec>
      <sec>
        <title>Key Digital Tool Features With Positive Impacts on the Health Condition</title>
        <sec>
          <title>Monitoring of Glycemia Levels</title>
          <p>Of the 42 studies, 22 (52%) incorporated a blood glucose meter to precisely monitor blood glucose levels during interventions; the blood glucose meter allowed the visual tracking of blood sugar curves by the patient and health professionals [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>-<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. In addition, 3 (7%) of the 42 studies included blood glucose meters permitting real-time continuous blood glucose monitoring [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref50">50</xref>].</p>
          <p>Of the 42 studies, 4 (10%) included an alert system [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]: “The online diabetes self-management system sent an SMS text message to care providers when the data exceeded the alerting range” [<xref ref-type="bibr" rid="ref68">68</xref>]; “The application automatically sent users reminders by simple e-mail and SMS: ‘Please enter your blood sugar/or other parameters into the eDiabetes application’” [<xref ref-type="bibr" rid="ref36">36</xref>]. Of the 42 studies, 9 (21%) included a bolus dosing system [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref74">74</xref>]: “An optional bolus dosing feature was available as an algorithm on the e-diary that allowed the patient to generate a premeal bolus insulin dose” [<xref ref-type="bibr" rid="ref57">57</xref>]. Of the 42 studies, 2 (5%) allowed the remote prescription of real-time continuous blood glucose monitoring devices [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref50">50</xref>].</p>
          <p>The 42 studies used different indicators to collect glycemic control data, such as (1) HbA<sub>1c</sub> levels in 27 (64%) studies, monitored through blood tests [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>-<xref ref-type="bibr" rid="ref48">48</xref>, <xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref69">69</xref>]; (2) blood glucose levels in 24 (57%) studies, monitored using data recorded by a blood glucose meter or a blood test [<xref ref-type="bibr" rid="ref32">32</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>-<xref ref-type="bibr" rid="ref48">48</xref>, <xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]; and (3) hypoglycemia events in 4 (10%) studies [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], based on self-reports or alert systems after the recording of blood glucose levels with a blood glucose meter. All interventional studies included in the review reported a reduction of between 0.433 mmol/L and 1.554 mmol/L in fasting blood glucose levels. The studies reported a statistically significant decrease in HbA<sub>1c</sub> levels ranging from 0.5% to 1.65% [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref68">68</xref>], as well as a drop of up to 1.554 mmol/L in blood glucose levels [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>, <xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>].</p>
        </sec>
        <sec>
          <title>Diet Monitoring</title>
          <p>Of the 42 studies, 13 (31%) included a meal planning system, with features such as generating shopping lists and recipes and calculating caloric intake [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>, <xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]; and 27 (64%) included a food diary system that could be shared with the health professional for comment [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>-<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref69">69</xref>]. Patients logged their data using a list of foods or by taking photographs. A caloric intake–counting feature was available in 11 (26%) of the 42 studies [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>, <xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. Of the 42 studies, 5 (12%) included a carbohydrate-counting system [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]: “The app provided an automated individualized calorie limit which was computed based on body weight, gender, age and activity level. The total daily carbohydrate intake was restricted to 40% of total daily calories” [<xref ref-type="bibr" rid="ref46">46</xref>]; “From the nutrition screen, the test persons manually entered carbohydrate values for their meals or scanned products to import the carbohydrate data into the app” [<xref ref-type="bibr" rid="ref53">53</xref>]. Of the 42 studies, 18 (43%) included pedagogical material, particularly nutrition education and knowledge evaluation [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref46">46</xref>-<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. To collect data on diet, the studies used the data logged on mobile or internet platforms or obtained from food diaries, 24-hour reminders, or calorie counting [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]. The health professionals evaluated diet quality using the shared data or validated questionnaires (eg, the Healthy Eating Index). The studies reported a better understanding of nutritional issues, greater confidence in maintaining a healthy diet, and an improvement in dietary behavior [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>].</p>
        </sec>
        <sec>
          <title>Physical Activity Monitoring</title>
          <p>Of the 42 studies, 6 (14%) monitored physical activity using a Bluetooth-connected device (Bluetooth-connected watch [<xref ref-type="bibr" rid="ref49">49</xref>], pedometer [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>], or accelerometer [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]), 8 (19%) used step counting via a Bluetooth-connected pedometer or a smartphone-integrated feature [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref67">67</xref>], and 16 (38%) included a graphic monitoring tool for monitoring physical activity [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. These graphs were generated automatically using pedometer data or after patients’ manual logging of their activities based on a list of predefined physical activities. A caloric expenditure–counting feature was often available: “Type, time, and intensity of any completed physical activity, which could be translated into calories burned. (BCT: prompt self-monitoring of behavior; provide feedback on performance)” [<xref ref-type="bibr" rid="ref35">35</xref>]. The studies used data logged on mobile or internet platforms and obtained from pedometers, accelerometers, or self-reported physical activity diaries to collect physical activity data. These data made it possible to adjust the automated recommendation messages and the messages from the health professionals with whom the data were shared. The studies reported a trend toward increased weekly physical activity owing to the technology-motivated engagement (eg, Chen et al [<xref ref-type="bibr" rid="ref68">68</xref>] report a significant increase in physical activity; <italic>P</italic>&#60;.001) [<xref ref-type="bibr" rid="ref30">30</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref69">69</xref>].</p>
        </sec>
        <sec>
          <title>Medication Monitoring</title>
          <p>Of the 42 studies, 16 (38%) included a medication adherence–tracking device [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>, <xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>], half of which (n=8, 50%) had a reminder feature [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. Of the 42 studies, 6 (14%) included an insulin dose–adjustment device used by the health professional or patient (eg, using a bolus dose algorithm) [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. Regarding the medication data collected, of the 42 studies, 6 (14%) reported medication adjustments [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], 7 (17%) analyzed the monitoring of prescribed insulin doses [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>], and 5 (12%) administered questionnaires on medication adherence [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. Finally, 4 (10%) of the 42 studies reported decreased oral antidiabetic doses after the interventions [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref68">68</xref>].</p>
        </sec>
        <sec>
          <title>Therapeutic Education</title>
          <p>Patients were provided various pedagogical tools to support their therapeutic education in 20 (48%) of the 42 studies [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>-<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. Among these 20 studies, web-based course modules were used in 4 (20%) [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]. Other tools were used to advance nutritional literacy [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]; or the tools talked about or referred to relevant articles on topics such as using a blood glucose meter, diabetes complications, physical activity, and tobacco use [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. Finally, 2 (10%) of the 20 studies proposed meditation or mindfulness exercises [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]. Personalized recommendation tools were used in 11 (26%) of the 42 studies [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]. These recommendations were either delivered by a health professional after an analysis of the patient’s logged data, generated automatically by an artificial intelligence algorithm, or planned according to a therapeutic education protocol. The pedagogical materials were often supported by electronic notebook tools where patients could jot down topics to discuss with their health professionals [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref67">67</xref>].</p>
        </sec>
        <sec>
          <title>Health Professional Involvement</title>
          <p>Among the 42 studies, communication between the health professional and patient was ensured through a chat feature in 13 (31%) studies [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>], by email in 7 (17%) studies [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref71">71</xref>], by SMS text messaging in 14 (33%) studies [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>, <xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref69">69</xref>], by telephone calls in 13 (31%) studies [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref69">69</xref>], and by videoconferencing in 4 (10%) studies [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>].</p>
          <p>Of the 42 studies, 33 (79%) included a tool for displaying patient data [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>-<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref68">68</xref>-<xref ref-type="bibr" rid="ref70">70</xref>], one-third of them (n=11, 33%) in real time, in the form of a graphic report. Of the 42 studies, 3 (7%) included a decision support tool [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref64">64</xref>], whereas 12 (29%) included a tool for setting and monitoring therapeutic goals that could be shared by the care provider and patient [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>].</p>
        </sec>
        <sec>
          <title>Other Health Data Monitoring</title>
          <p>The monitoring of other health data concerned weight loss. Of the 42 studies, 16 (38%) monitored weight using a graphic representation over time [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref48">48</xref>, <xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]. Of these 16 studies, 6 (38%) collected automated data using a Bluetooth-connected weight scale [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>]. In addition, 7 (17%) of the 42 studies enabled the sharing of blood test results [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. Kobayashi et al [<xref ref-type="bibr" rid="ref42">42</xref>] used a Bluetooth-connected tensiometer to transmit blood pressure readings to a cloud-based server, making it possible to summarize and present the data to patients and their primary care physicians to promote self-management, monitoring, and follow-up. The studies reported a statistically significant reduction in weight ranging from 3 to 6.2 kg [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>] and in BMI ranging from 1.6 kg/m<sup>2</sup> to 4 kg/m<sup>2</sup> [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>].</p>
        </sec>
        <sec>
          <title>Health Care Management</title>
          <p>Of the 42 studies, 20 (48%) included personal spaces in their technologies [<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>-<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. In these spaces, it was possible to view a dashboard summarizing the logged health data, monitor exchanges with health professionals, and generate reports that could be shared by the patient and downloaded by the health professionals for inclusion in the medical file [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. Social support was promoted through links to social networks in 6 (14%) of the 42 studies [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref48">48</xref>]. Of the 42 studies, 6 (14%) included a web-based appointment scheduling tool, facilitating monitoring and follow-up by the health professionals [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. Finally, Holmen et al [<xref ref-type="bibr" rid="ref69">69</xref>] made technical support available 7 days a week to users of their technology.</p>
        </sec>
        <sec>
          <title>Combination of Interventions</title>
          <p>Studies showing significant positive results were those combining the involvement of a health professional with the monitoring of glycemia levels, diet, physical activity, and medication [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]. Of the 42 studies, 1 (2%) combined support from a health professional with the monitoring of glycemia levels, diet, and physical activity; therapeutic education; and a follow-up of body weight [<xref ref-type="bibr" rid="ref29">29</xref>]. Some of the studies (7/42, 17%) only added to the involvement of a health professional the monitoring of glycemia levels and physical activity (n=1, 14%) [<xref ref-type="bibr" rid="ref40">40</xref>], the monitoring of glycemia levels alone (n=2, 29%) [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref58">58</xref>], diet and medication monitoring with therapeutic education (n=1, 14%) [<xref ref-type="bibr" rid="ref31">31</xref>] or without therapeutic education (n=1, 14%) [<xref ref-type="bibr" rid="ref35">35</xref>], diet monitoring and therapeutic education (n=1, 14%) [<xref ref-type="bibr" rid="ref70">70</xref>], and physical activity and body weight monitoring (n=1, 14%) [<xref ref-type="bibr" rid="ref42">42</xref>]. Of the 42 studies, 2 (5%) with positive significant results evaluated the combination of a health professional and the monitoring of glycemia levels, diet, and medication (n=1, 50%) [<xref ref-type="bibr" rid="ref30">30</xref>] and therapeutic education and body weight follow-up (n=1, 50%) [<xref ref-type="bibr" rid="ref34">34</xref>]. Most often (23/42, 55%), the combined strategies involved a health professional and the monitoring of glycemia levels and diet (<xref ref-type="supplementary-material" rid="app6">Multimedia Appendix 6</xref> [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]).</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This study mapped telehealth interventions tailored to the needs of patients with type 2 diabetes supported by a health professional. This review—despite the range of scientific literature available; the complex nature of these interventions; and the heterogeneity of study designs, populations, organizational care contexts, measures, and result indicators used—revealed a trend suggesting the effectiveness of telehealth interventions with health professional involvement in improving health outcomes. The use of everyday technologies in these interventions could facilitate their accessibility and usability, which would facilitate their implementation in the longer term. On the basis of our exploration of the literature, we were able to classify the key features of digital tools that may have a positive effect on intervention outcomes into eight categories: (1) monitoring of glycemia levels, (2) diet monitoring, (3) physical activity monitoring, (4) medication monitoring, (5) therapeutic education, (6) health professional support, (7) other health data monitoring, and (8) health care management (<xref rid="figure5" ref-type="fig">Figure 5</xref>).</p>
        <p>The duration of the interventions varied significantly among the studies, with interventions lasting 1 month to 18 months. A recent meta-analysis on the effectiveness of telemedicine application for chronic diseases found that for people living with type 2 diabetes, HbA<sub>1c</sub> levels began to decrease after up to 12 months of telemedicine intervention compared with interventions lasting 6 months [<xref ref-type="bibr" rid="ref75">75</xref>]. These results were also supported in a study by Timpel et al [<xref ref-type="bibr" rid="ref76">76</xref>], where HbA<sub>1c</sub> levels began to decrease in participants after 12 months of long-term telemedicine intervention. Given that the HbA<sub>1c</sub> level is a recognized indicator of glycemic control over a retrospective period, reflecting average blood glucose levels over approximately 3 months, it is regarded as a standard for assessing the effectiveness of long-term diabetes interventions [<xref ref-type="bibr" rid="ref77">77</xref>]. This measure offers a more stable view of a patient’s glycemia levels than instantaneous measurements, which can be influenced by many immediate factors [<xref ref-type="bibr" rid="ref77">77</xref>]. Longer interventions could allow for more accurate adjustments in treatments and disease management behaviors as well as provide enough time for these changes to result in improvements in glycemic control.</p>
        <p>The health professionals involved in these studies were primarily physicians, dietitians, and nurses. Nearly half (19/42, 45%) of the studies involved a multidisciplinary care team [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref71">71</xref>] (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>). The studies showed that health technologies could help optimize the therapeutic education and monitoring of people living with type 2 diabetes through collecting and sharing information between consultations. Care provider personnel would thus be better able to focus on other aspects of their practice during consultations. Some of the interventions (4/42, 10%) used a videoconferencing platform for consultations with the health professional to make the exchanges more natural and pleasant [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. A recent narrative review that included 12 randomized controlled trials assessing the effectiveness of telemedicine versus conventional counseling, demonstrated that the counseling and monitoring of patients living with diabetes via telemedicine was more effective than conventional counseling [<xref ref-type="bibr" rid="ref78">78</xref>]. Similarly, health technologies could help improve the efficiency of practical tasks performed by health professionals, for example, by producing more concise automatically generated reports that can be shared among the care team, thus fostering interdisciplinary monitoring and follow-up. They also offer the possibility of monitoring patients in real time and sharing targeted information with them, thereby facilitating timely adjustments. Telehealth tools enable the continuous monitoring of blood glucose levels, physical activity, diet, medication intake, and other health indicators. This enables patients and health care providers to quickly detect fluctuations in blood sugar levels and take appropriate action to maintain optimal control of blood sugar levels [<xref ref-type="bibr" rid="ref1">1</xref>]. The features of telehealth tools can provide personalized recommendations and advice based on each patient’s specific data [<xref ref-type="bibr" rid="ref2">2</xref>]; for example, patients can receive medication reminders, nutritional advice tailored to their dietary preferences, and suggestions for physical activities based on their condition and health goals [<xref ref-type="bibr" rid="ref2">2</xref>]. Telehealth tools offer educational resources and information on type 2 diabetes [<xref ref-type="bibr" rid="ref3">3</xref>]. Patients can access educational materials, explanatory videos, meal plans, and tips to improve their understanding of the disease and its management [<xref ref-type="bibr" rid="ref3">3</xref>]. This promotes patient empowerment by enabling them to actively participate in the management of their health [<xref ref-type="bibr" rid="ref3">3</xref>-<xref ref-type="bibr" rid="ref5">5</xref>]. Telehealth tools can include features such as appointment reminders, food diaries, and physical activity logs. These features help patients track their progress, stay engaged with their treatment, and maintain their motivation [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref5">5</xref>].</p>
        <p>Our findings are in line with the chronic care model [<xref ref-type="bibr" rid="ref79">79</xref>]. Telehealth interventions, as observed in our study, frequently incorporate goal-setting tools that empower patients to set and track health-related objectives, aligning with the model’s emphasis on self-management support. In addition, our results underscore the vital role of health professional support within telehealth interventions, enabling remote monitoring and timely guidance, consistent with the model’s focus on patient-centered care. Social support emerged in our findings, with patients benefiting from the encouragement of their social networks—a concept aligned with the chronic care model’s recognition of involving the patient’s social support system. Finally, our research highlights the inclusion of educational materials in telehealth interventions, providing patients with essential knowledge about their condition, in line with the model’s emphasis on patient education. Together, these elements within telehealth strategies contribute to patient empowerment, improved self-management, and enhanced outcomes for the management of chronic conditions such as diabetes, emphasizing the importance of a comprehensive approach to health care delivery, even in remote or web-based settings.</p>
        <p>However, there are also potential limitations and challenges associated with the use of telehealth tools for the management of type 2 diabetes. The use of telehealth tools may be limited by internet access, technological skills, and the availability of the necessary devices [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. Populations that have been historically marginalized or disadvantaged may face digital disparities, limiting their ability to benefit fully from these tools. It is thus essential to recognize that some patients may require additional human support. Interaction with health care providers may be necessary to obtain answers to questions, resolve problems, and receive emotional support. Furthermore, the use of telehealth tools involves the collection, storage, and sharing of sensitive health data. It is crucial to implement robust security measures to protect data confidentiality and prevent privacy breaches [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. Telehealth tools use monitoring devices to collect data, such as blood glucose meters or continuous blood glucose monitoring sensors. However, these devices can have technical limitations and measurement errors, which can affect the accuracy of the data collected and potentially influence treatment decisions [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. Given that diabetes management is characterized by a long process of therapeutic education, monitoring, and follow-up, technological support would be a helpful asset in primary health care because it would help maintain motivation [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref70">70</xref>] through the use of numerous tools (goal-setting tools and shared decision-making support tools, recipes, informational content, etc), by facilitating interactions with a health professional, and by promoting access to care (eg, with the possibility of using multilingual resources).</p>
        <fig id="figure5" position="float">
          <label>Figure 5</label>
          <caption>
            <p>Classification of digital features for diabetes self-management and monitoring.</p>
          </caption>
          <graphic xlink:href="medinform_v12i1e46699_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Recommendations for Future Designs</title>
        <p>Telehealth offers many opportunities for diabetes self-management and monitoring, enabling patients to benefit from remote care, continuous monitoring, and personalized support. The use of continuous blood glucose monitoring devices, mobile apps, web-based platforms, and other technologies facilitates the collection and tracking of diabetes-related data [<xref ref-type="bibr" rid="ref9">9</xref>]. The introduction of web-based educational resources, web-based learning modules, and self-help tools to help patients better understand their disease as well as manage their diet, physical activity, medication, and monitoring of blood glucose levels promotes patient self-management and empowerment [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>]. In addition, web-based support via secure messaging to answer patients’ questions and respond to their concerns supports therapeutic education and keeps them engaged. Indeed, technology developers will need to set up clear and effective communication channels between patients and health professionals. This may include web-based consultations, secure message exchanges, and regular reports on patient progress [<xref ref-type="bibr" rid="ref11">11</xref>]. Finally, it will be important to consider the integration of these telehealth interventions into existing health care systems, ensuring coordination and continuity of care. It will be necessary to ensure that data collected by remote monitoring devices are accessible to health professionals and integrated into patients’ medical records [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
      </sec>
      <sec>
        <title>Limitations of Included Studies</title>
        <p>The studies identified in this review involved voluntary patient participation. In particular, the studies favored individuals with good technology literacy. The selection bias inherent in voluntary patient participation and the preference for technology-literate individuals suggest that the findings might not be generalizable to the broader population of people with diabetes. The indicators used to assess the effectiveness of the interventions were primarily dietary intake; clinical indicators such as glycemia levels, HbA<sub>1c</sub> levels, blood pressure, and cholesterol levels; physical activity; medication adherence; motivation; and the use of telehealth technology. Although positive changes in these indicators were noted in most clinical results, this may translate into something other than rigorous clinical parameters. Different strategies were used to collect data, notably involving innovative digital tools (although these tools did not undergo a validation study). In addition, lifestyle changes (dietary planning and physical activity) were measured using the patient self-administered digital questionnaires, leaving the door open to all biases inherent in self-reporting. A meta-analysis of these data would help inform a position in this regard.</p>
        <p>The heterogeneity of the included studies posed a real challenge in interpreting the results. Aside from the various methods used, which yielded different levels of evidence, the interventions were based mainly on effecting behavior changes through therapeutic education supported by digital tools and a health professional; yet, none of the studies assessed the impact on the results of the context within which these technologies were used, such as concurrent public health policies (eg, diabetes or obesity prevention campaigns, the promotion of a balanced diet, physical activity, or tobacco use).</p>
        <p>Moreover, the literature states that 90% of people with diabetes have at least 1 other chronic disease. Nonetheless, few interventions have provided the integrated management of diabetes and other pathologies. Specifically, renal and cardiac risks have not always been assessed. The multipathological context should be systematically considered when designing studies because multiple medication use (eg, sulfonylureas and insulin) can cause iatrogenic hypoglycemia and influence the clinical parameters [<xref ref-type="bibr" rid="ref80">80</xref>-<xref ref-type="bibr" rid="ref82">82</xref>]. Similarly, the different stages of diabetes severity should be documented to foster a more accurate interpretation of the results.</p>
        <p>The varying durations of the interventions, ranging from 1 month to 18 months, and the differing technologies used emphasize that outcomes such as improvements in HbA<sub>1c</sub> levels are not uniform across all studies. The positive association observed with longer interventions and the reduction in HbA<sub>1c</sub> levels may not hold true in every context or for every patient demographic. The role of health professionals in these interventions is undoubtedly significant, but the translation of these findings into practice must consider the individual needs and circumstances of diverse patient populations, including access issues and technological literacy. The integration of everyday technologies seems promising for broader implementation; however, this assumption requires careful consideration of the digital disparities that may exist, particularly among groups that have been historically marginalized or disadvantaged.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations of This Review</title>
        <p>To further leverage the qualitative nature of the content analyzed in the studies, we performed a descriptive content analysis of the data using NVivo (release 1.7). This allowed us to supplement our research with a narrative account of the selected studies. The abundance of literature on the subject attests to a worldwide questioning of digital health policies. The COVID-19 pandemic led to a doubling of the number of annual publications on the topic of telehealth interventions used for type 2 diabetes or prediabetes self-management and monitoring with health professional involvement. Given the rapid development of technologies and research, which has only escalated in recent years, a systematic review would help provide invaluable data on the effectiveness of these interventions. This scoping review included studies published in peer-reviewed journals and is thus subject to publication bias owing to the well-documented notion that researchers and journals tend to publish positive results. In addition, we limited ourselves to selecting studies published in French or English from 2010 given the rapid pace of technological development and the consequent rapid increase in the literature. Future researchers should consider more inclusive approaches, such as conducting systematic reviews that encompass gray literature and unpublished studies. This ensures a more comprehensive and unbiased overview of existing literature on the topic.</p>
        <p>The results of this review did not allow us to identify how the 8 key digital tool features should be developed and combined to help improve health outcomes. However, the strategy most often combined with telehealth interventions facilitating interaction with health professionals was the monitoring of glycemia levels, diet, and physical activity. A few of the studies (7/42, 17%) also included medication monitoring and therapeutic education. Future studies should perform in-depth analyses of the usability and acceptability of these technologies to highlight the design issues and shed light on health policies.</p>
        <p>The diversity of the interventions analyzed underscores the necessity to acknowledge the unique challenges and issues inherent to each specific population. Such issues can encompass socioeconomic factors, cultural differences, accessibility to health services, and varying levels of health literacy, all of which can significantly influence the effectiveness of interventions; for instance, interventions that succeed in urban environments with high connectivity and technologically savvy populations may not yield identical results in rural or low-income areas where internet access is scarce and digital literacy is an issue. Moreover, the cultural context may impact patient engagement and the suitability of educational materials. Each population may hold distinct health beliefs, practices, and priorities, which must be considered during the design and implementation of health interventions. Recognizing these disparities is critical to understanding why results from 1 group cannot be generalized to another. Public health strategies must develop resource allocation policies and create interventions focused on the users’ needs. Hence, although telehealth presents a promising avenue for improving diabetes management, its application must be nuanced and considerate of the public health challenges unique to each specific population to be truly effective and equitable.</p>
      </sec>
      <sec>
        <title>Future Research Prospects</title>
        <p>With regard to gaps in the literature, some questions require further research. This scoping review revealed a need for long-term implementation studies, possibly because telehealth programs require a less-structured time commitment and could be used over extended periods. Long-term evaluation studies are also needed to facilitate the implementation of telehealth interventions. Further studies on adherence and engagement could explore the factors that influence patients’ adherence to telehealth interventions and their engagement in diabetes self-management. These studies will also help to identify effective strategies for encouraging patients’ active participation and maintaining their motivation over the long term. Evaluation frameworks should incorporate reports on participant engagement and satisfaction, acceptability, security, and costs into future telehealth interventions because these will facilitate their translation into clinical practice. In addition, the measurement of the effects of interventions should include measures other than clinical data, such as patient-reported experience measures and patient-reported outcome measures to ensure that these interventions are meeting the needs of patients. In addition, multimorbidity was mentioned by only a few of the included studies (7/42, 17%) and warrants further research to assess the impact of these interventions on health [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]. Additional studies could define standardized assessment criteria for telehealth interventions that support the therapeutic management of patients with diabetes and multiple comorbidities. The impact of equity of access to care on the use of telehealth interventions for populations considered vulnerable, including populations with low-income status, rural or remote populations, and culturally diverse groups, will need to be studied. A better understanding of these impacts will help identify potential barriers and strategies to reduce disparities and improve equitable access to telehealth [<xref ref-type="bibr" rid="ref12">12</xref>]. Finally, it will be vital to evaluate the effectiveness of integrating telehealth interventions into existing health care systems, including collaboration among health professionals, data sharing, and care coordination. This will help distinguish best practices for the successful integration of telehealth into clinical care and existing health care systems [<xref ref-type="bibr" rid="ref12">12</xref>]. Of the 42 studies, 3 (7%) assessed the impact on the cost of care [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]. The macroeconomic implications of these telehealth interventions for health care systems warrant future studies to shed clearer light on health policies. Finally, the COVID-19 pandemic has revealed the various structural and organizational shortcomings of health care around the globe. It has also accelerated the dissemination and adoption of digital tools and advanced the digital ambitions of governments worldwide. The abundance of publications means that future studies can perform a meta-analysis of randomized controlled trials. Our analysis underscores the critical role of multidisciplinary health care teams and promotes the integration of ubiquitous technologies into daily health management practices to achieve superior patient outcomes. Furthermore, this review stresses the necessity of considering the long-term viability of telehealth solutions, patient adherence, and the seamless incorporation of these solutions into current health care frameworks in subsequent research.</p>
        <p>Finally, although we included studies conducted in different parts of the world in this scoping review, we did not find relevant studies conducted in Canada, indicating an opportunity for research tailored to the Canadian context. For the implementation of future telehealth interventions to improve diabetes management in Canada, it is recommended to consider the specificities of the Canadian health care system, such as the heterogeneity of its organization across different provinces, the diversity of its population, and its varied health resources. It would be wise to design personalized interventions that address the unique needs of patients with diabetes within the Canadian population, particularly in Indigenous communities that are disproportionately affected by diabetes, including linguistic and cultural considerations. Strategies for equitable access to telehealth technologies for populations that have been historically marginalized or those living in remote areas should also be considered. Training health professionals in telehealth tools and best practices for web-based care is equally essential. Moreover, interdisciplinary and intersectoral collaboration would be beneficial to effectively integrate telehealth into primary care, allowing for coordinated and consistent follow-up. Finally, by anticipating challenges related to privacy and data security, interventions should incorporate robust security measures to protect sensitive patient information while focusing on a personalized approach and the development of patient-centered interventions and technologies.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This review systematically maps out the effectiveness of telehealth interventions for managing type 2 diabetes, with a focus on the enhanced outcomes gained through the involvement of health professionals. It presents a detailed categorization of the pivotal characteristics of digital tools into 8 distinct areas that significantly influence the success of these interventions. The evidence-based data suggest that participation in sustained telehealth interventions with health professional involvement helps improve health outcomes and type 2 diabetes–related behavior, reducing the risks of complications. However, despite our identification of the key digital tool features of these interventions, it remains to be seen how to combine and translate them into long-term usable components in specific care contexts. Nonetheless, the results are promising for future health care because they point to consolidating care through a single platform, which could improve patients’ quality of life while encouraging active self-management. They also shed light on developing evidence-based telehealth programs that can be adapted to specific care contexts and offer decision makers more effective options for funding diabetes management programs. Ultimately, this review aims to enrich the understanding of telehealth’s role in diabetes care and to outline specific domains for future research that will inform policy making and the advancement of telehealth practices.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist.</p>
        <media xlink:href="medinform_v12i1e46699_app1.pdf" xlink:title="PDF File  (Adobe PDF File), 517 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Search strategy.</p>
        <media xlink:href="medinform_v12i1e46699_app2.docx" xlink:title="DOCX File , 14 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Data extraction table.</p>
        <media xlink:href="medinform_v12i1e46699_app3.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 18 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Health professional involvement.</p>
        <media xlink:href="medinform_v12i1e46699_app4.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app5">
        <label>Multimedia Appendix 5</label>
        <p>Digital features of the interventions.</p>
        <media xlink:href="medinform_v12i1e46699_app5.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app6">
        <label>Multimedia Appendix 6</label>
        <p>Studies showing significant positive health outcomes.</p>
        <media xlink:href="medinform_v12i1e46699_app6.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 12 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">DASH</term>
          <def>
            <p>Dietary Approaches to Stop Hypertension</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">HbA<sub>1c</sub></term>
          <def>
            <p>glycated hemoglobin</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">PRISMA-ScR</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Wild</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Roglic</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Green</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Sicree</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>King</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Global prevalence of diabetes: estimates for the year 2000 and projections for 2030</article-title>
          <source>Diabetes Care</source>
          <year>2004</year>
          <month>05</month>
          <volume>27</volume>
          <issue>5</issue>
          <fpage>1047</fpage>
          <lpage>53</lpage>
          <pub-id pub-id-type="doi">10.2337/diacare.27.5.1047</pub-id>
          <pub-id pub-id-type="medline">15111519</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="web">
          <article-title>IDF diabetes atlas 7th edition</article-title>
          <source>IDF Diabetes Atlas</source>
          <year>2015</year>
          <access-date>2024-01-19</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://diabetesatlas.org/atlas/seventh-edition/">https://diabetesatlas.org/atlas/seventh-edition/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <collab>Diabetes Canada</collab>
          </person-group>
          <article-title>Diabetes Canada 2018 clinical practice guidelines for the prevention and management of diabetes in Canada</article-title>
          <source>Can J Diabetes</source>
          <year>2018</year>
          <volume>42</volume>
          <issue>1</issue>
          <fpage>A1</fpage>
          <lpage>A18, S1-S326</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.sciencedirect.com/journal/canadian-journal-of-diabetes/vol/42/suppl/S1"/>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ivers</surname>
              <given-names>NM</given-names>
            </name>
            <name name-style="western">
              <surname>Jiang</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Alloo</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Singer</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Ngui</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Casey</surname>
              <given-names>CG</given-names>
            </name>
            <name name-style="western">
              <surname>Yu</surname>
              <given-names>CH</given-names>
            </name>
          </person-group>
          <article-title>Diabetes Canada 2018 clinical practice guidelines: key messages for family physicians caring for patients living with type 2 diabetes</article-title>
          <source>Can Fam Physician</source>
          <year>2019</year>
          <month>01</month>
          <volume>65</volume>
          <issue>1</issue>
          <fpage>14</fpage>
          <lpage>24</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.cfp.ca/cgi/pmidlookup?view=long&#38;pmid=30674509"/>
          </comment>
          <pub-id pub-id-type="medline">30674509</pub-id>
          <pub-id pub-id-type="pii">65/1/14</pub-id>
          <pub-id pub-id-type="pmcid">PMC6347316</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <collab>American Diabetes Association Professional Practice Committee</collab>
          </person-group>
          <article-title>6. Glycemic targets: standards of medical care in diabetes-2022</article-title>
          <source>Diabetes Care</source>
          <year>2022</year>
          <month>01</month>
          <day>01</day>
          <volume>45</volume>
          <issue>Suppl 1</issue>
          <fpage>S83</fpage>
          <lpage>96</lpage>
          <pub-id pub-id-type="doi">10.2337/dc22-S006</pub-id>
          <pub-id pub-id-type="medline">34964868</pub-id>
          <pub-id pub-id-type="pii">138927</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bhattacherjee</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Hikmet</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Menachemi</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Kayhan</surname>
              <given-names>VO</given-names>
            </name>
            <name name-style="western">
              <surname>Brooks</surname>
              <given-names>RG</given-names>
            </name>
          </person-group>
          <article-title>The differential performance effects of healthcare information technology adoption</article-title>
          <source>Inf Syst Manag</source>
          <year>2006</year>
          <month>12</month>
          <day>22</day>
          <volume>24</volume>
          <issue>1</issue>
          <fpage>5</fpage>
          <lpage>14</lpage>
          <pub-id pub-id-type="doi">10.1080/10580530601036778</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kabir</surname>
              <given-names>MJ</given-names>
            </name>
            <name name-style="western">
              <surname>Heidari</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Honarvar</surname>
              <given-names>MR</given-names>
            </name>
            <name name-style="western">
              <surname>Khatirnamani</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Rafiei</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <article-title>Challenges in the implementation of an electronic referral system: a qualitative study in the Iranian context</article-title>
          <source>Int J Health Plann Manage</source>
          <year>2023</year>
          <month>01</month>
          <day>21</day>
          <volume>38</volume>
          <issue>1</issue>
          <fpage>69</fpage>
          <lpage>84</lpage>
          <pub-id pub-id-type="doi">10.1002/hpm.3563</pub-id>
          <pub-id pub-id-type="medline">35988065</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nathan</surname>
              <given-names>DM</given-names>
            </name>
            <name name-style="western">
              <surname>Cleary</surname>
              <given-names>PA</given-names>
            </name>
            <name name-style="western">
              <surname>Backlund</surname>
              <given-names>JY</given-names>
            </name>
            <name name-style="western">
              <surname>Genuth</surname>
              <given-names>SM</given-names>
            </name>
            <name name-style="western">
              <surname>Lachin</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Orchard</surname>
              <given-names>TJ</given-names>
            </name>
            <name name-style="western">
              <surname>Raskin</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Zinman</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes</article-title>
          <source>N Engl J Med</source>
          <year>2005</year>
          <month>12</month>
          <day>22</day>
          <volume>353</volume>
          <issue>25</issue>
          <fpage>2643</fpage>
          <lpage>53</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/16371630"/>
          </comment>
          <pub-id pub-id-type="doi">10.1056/NEJMoa052187</pub-id>
          <pub-id pub-id-type="medline">16371630</pub-id>
          <pub-id pub-id-type="pii">353/25/2643</pub-id>
          <pub-id pub-id-type="pmcid">PMC2637991</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Toma</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Athanasiou</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Harling</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Darzi</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Ashrafian</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Online social networking services in the management of patients with diabetes mellitus: systematic review and meta-analysis of randomised controlled trials</article-title>
          <source>Diabetes Res Clin Pract</source>
          <year>2014</year>
          <month>11</month>
          <volume>106</volume>
          <issue>2</issue>
          <fpage>200</fpage>
          <lpage>11</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://hdl.handle.net/10044/1/26360"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.diabres.2014.06.008</pub-id>
          <pub-id pub-id-type="medline">25043399</pub-id>
          <pub-id pub-id-type="pii">S0168-8227(14)00276-9</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Smith</surname>
              <given-names>AC</given-names>
            </name>
            <name name-style="western">
              <surname>Thomas</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Snoswell</surname>
              <given-names>CL</given-names>
            </name>
            <name name-style="western">
              <surname>Haydon</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Mehrotra</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Clemensen</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Caffery</surname>
              <given-names>LJ</given-names>
            </name>
          </person-group>
          <article-title>Telehealth for global emergencies: implications for coronavirus disease 2019 (COVID-19)</article-title>
          <source>J Telemed Telecare</source>
          <year>2020</year>
          <month>06</month>
          <volume>26</volume>
          <issue>5</issue>
          <fpage>309</fpage>
          <lpage>13</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://journals.sagepub.com/doi/abs/10.1177/1357633X20916567?url_ver=Z39.88-2003&#38;rfr_id=ori:rid:crossref.org&#38;rfr_dat=cr_pub  0pubmed"/>
          </comment>
          <pub-id pub-id-type="doi">10.1177/1357633X20916567</pub-id>
          <pub-id pub-id-type="medline">32196391</pub-id>
          <pub-id pub-id-type="pmcid">PMC7140977</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Picot</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Cradduck</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>The telehealth industry in Canada: industry profile and capability analysis</article-title>
          <source>The Keston Group and Infotelmed Communications Inc</source>
          <year>2000</year>
          <month>3</month>
          <day>30</day>
          <access-date>2024-01-19</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://citeseerx.ist.psu.edu/document?repid=rep1&#38;type=pdf&#38;doi=c7f26186673239a22d731d13857780ba0a5c7918">https://citeseerx.ist.psu.edu/document?repid=rep1&#38;type=pdf&#38;doi =c7f26186673239a22d731d13857780ba0a5c7918</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kairy</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Télérééducation, téléréadaptation et e-santé : définition, évolution et diversité des points de vue sur ces concepts</article-title>
          <source>Edimark.fr</source>
          <year>2017</year>
          <month>1</month>
          <day>20</day>
          <access-date>2024-01-19</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.edimark.fr/revues/actualites-en-mpr/n-1-janvier-2017/telereeducation-telereadaptation-et-e-sante-definition-evolution-et-diversite-des-points-de-vue-sur-ces-concepts">https://www.edimark.fr/revues/actualites-en-mpr/n-1-janvier-2017/telereeducation-telere adaptation-et-e-sante-definition-evolution-et-diversite-des-points-de-vue-sur-ces-concepts</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Yaya</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Raffelini</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>[Technological transformations and evolution of the medical practice: current status, issues and perspectives for the development of telemedicine]</article-title>
          <source>Rev Med Brux</source>
          <year>2009</year>
          <volume>30</volume>
          <issue>2</issue>
          <fpage>83</fpage>
          <lpage>91</lpage>
          <pub-id pub-id-type="medline">19517904</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ramadas</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Quek</surname>
              <given-names>KF</given-names>
            </name>
            <name name-style="western">
              <surname>Chan</surname>
              <given-names>CK</given-names>
            </name>
            <name name-style="western">
              <surname>Oldenburg</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Web-based interventions for the management of type 2 diabetes mellitus: a systematic review of recent evidence</article-title>
          <source>Int J Med Inform</source>
          <year>2011</year>
          <month>06</month>
          <volume>80</volume>
          <issue>6</issue>
          <fpage>389</fpage>
          <lpage>405</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2011.02.002</pub-id>
          <pub-id pub-id-type="medline">21481632</pub-id>
          <pub-id pub-id-type="pii">S1386-5056(11)00047-5</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Crosson</surname>
              <given-names>JC</given-names>
            </name>
            <name name-style="western">
              <surname>Ohman-Strickland</surname>
              <given-names>PA</given-names>
            </name>
            <name name-style="western">
              <surname>Cohen</surname>
              <given-names>DJ</given-names>
            </name>
            <name name-style="western">
              <surname>Clark</surname>
              <given-names>EC</given-names>
            </name>
            <name name-style="western">
              <surname>Crabtree</surname>
              <given-names>BF</given-names>
            </name>
          </person-group>
          <article-title>Typical electronic health record use in primary care practices and the quality of diabetes care</article-title>
          <source>Ann Fam Med</source>
          <year>2012</year>
          <month>05</month>
          <day>14</day>
          <volume>10</volume>
          <issue>3</issue>
          <fpage>221</fpage>
          <lpage>7</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.annfammed.org/cgi/pmidlookup?view=long&#38;pmid=22585886"/>
          </comment>
          <pub-id pub-id-type="doi">10.1370/afm.1370</pub-id>
          <pub-id pub-id-type="medline">22585886</pub-id>
          <pub-id pub-id-type="pii">10/3/221</pub-id>
          <pub-id pub-id-type="pmcid">PMC3354971</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Tenforde</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Nowacki</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Jain</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Hickner</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>The association between personal health record use and diabetes quality measures</article-title>
          <source>J Gen Intern Med</source>
          <year>2012</year>
          <month>04</month>
          <day>18</day>
          <volume>27</volume>
          <issue>4</issue>
          <fpage>420</fpage>
          <lpage>4</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/22005937"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s11606-011-1889-0</pub-id>
          <pub-id pub-id-type="medline">22005937</pub-id>
          <pub-id pub-id-type="pmcid">PMC3304034</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Marcolino</surname>
              <given-names>MS</given-names>
            </name>
            <name name-style="western">
              <surname>Maia</surname>
              <given-names>JX</given-names>
            </name>
            <name name-style="western">
              <surname>Alkmim</surname>
              <given-names>MB</given-names>
            </name>
            <name name-style="western">
              <surname>Boersma</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Ribeiro</surname>
              <given-names>AL</given-names>
            </name>
          </person-group>
          <article-title>Telemedicine application in the care of diabetes patients: systematic review and meta-analysis</article-title>
          <source>PLoS One</source>
          <year>2013</year>
          <month>11</month>
          <day>8</day>
          <volume>8</volume>
          <issue>11</issue>
          <fpage>e79246</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0079246"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0079246</pub-id>
          <pub-id pub-id-type="medline">24250826</pub-id>
          <pub-id pub-id-type="pii">PONE-D-13-21538</pub-id>
          <pub-id pub-id-type="pmcid">PMC3826722</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Malanda</surname>
              <given-names>UL</given-names>
            </name>
            <name name-style="western">
              <surname>Welschen</surname>
              <given-names>LM</given-names>
            </name>
            <name name-style="western">
              <surname>Riphagen</surname>
              <given-names>II</given-names>
            </name>
            <name name-style="western">
              <surname>Dekker</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Nijpels</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Bot</surname>
              <given-names>SD</given-names>
            </name>
          </person-group>
          <article-title>Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin</article-title>
          <source>Cochrane Database Syst Rev</source>
          <year>2012</year>
          <month>01</month>
          <day>18</day>
          <volume>1</volume>
          <fpage>CD005060</fpage>
          <pub-id pub-id-type="doi">10.1002/14651858.CD005060.pub3</pub-id>
          <pub-id pub-id-type="medline">22258959</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Pal</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Eastwood</surname>
              <given-names>SV</given-names>
            </name>
            <name name-style="western">
              <surname>Michie</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Farmer</surname>
              <given-names>AJ</given-names>
            </name>
            <name name-style="western">
              <surname>Barnard</surname>
              <given-names>ML</given-names>
            </name>
            <name name-style="western">
              <surname>Peacock</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Wood</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Inniss</surname>
              <given-names>JD</given-names>
            </name>
            <name name-style="western">
              <surname>Murray</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Computer-based diabetes self-management interventions for adults with type 2 diabetes mellitus</article-title>
          <source>Cochrane Database Syst Rev</source>
          <year>2013</year>
          <month>03</month>
          <day>28</day>
          <volume>2013</volume>
          <issue>3</issue>
          <fpage>CD008776</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/23543567"/>
          </comment>
          <pub-id pub-id-type="doi">10.1002/14651858.CD008776.pub2</pub-id>
          <pub-id pub-id-type="medline">23543567</pub-id>
          <pub-id pub-id-type="pmcid">PMC6486319</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Howland</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Wakefield</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Assessing telehealth interventions for physical activity and sedentary behavior self-management in adults with type 2 diabetes mellitus: an integrative review</article-title>
          <source>Res Nurs Health</source>
          <year>2021</year>
          <month>02</month>
          <day>22</day>
          <volume>44</volume>
          <issue>1</issue>
          <fpage>92</fpage>
          <lpage>110</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/33091168"/>
          </comment>
          <pub-id pub-id-type="doi">10.1002/nur.22077</pub-id>
          <pub-id pub-id-type="medline">33091168</pub-id>
          <pub-id pub-id-type="pmcid">PMC8486348</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Anderson</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>O'Connell</surname>
              <given-names>SS</given-names>
            </name>
            <name name-style="western">
              <surname>Thomas</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Chimmanamada</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>Telehealth interventions to improve diabetes management among Black and Hispanic patients: a systematic review and meta-analysis</article-title>
          <source>J Racial Ethn Health Disparities</source>
          <year>2022</year>
          <month>12</month>
          <day>09</day>
          <volume>9</volume>
          <issue>6</issue>
          <fpage>2375</fpage>
          <lpage>86</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/35000144"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s40615-021-01174-6</pub-id>
          <pub-id pub-id-type="medline">35000144</pub-id>
          <pub-id pub-id-type="pii">10.1007/s40615-021-01174-6</pub-id>
          <pub-id pub-id-type="pmcid">PMC8742712</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <collab>American Diabetes Association Professional Practice Committee</collab>
          </person-group>
          <article-title>7. Diabetes technology: standards of medical care in diabetes-2022</article-title>
          <source>Diabetes Care</source>
          <year>2022</year>
          <month>01</month>
          <day>01</day>
          <volume>45</volume>
          <issue>Suppl 1</issue>
          <fpage>S97</fpage>
          <lpage>112</lpage>
          <pub-id pub-id-type="doi">10.2337/dc22-S007</pub-id>
          <pub-id pub-id-type="medline">34964871</pub-id>
          <pub-id pub-id-type="pii">138911</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>May</surname>
              <given-names>CR</given-names>
            </name>
            <name name-style="western">
              <surname>Finch</surname>
              <given-names>TL</given-names>
            </name>
            <name name-style="western">
              <surname>Cornford</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Exley</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Gately</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Kirk</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Jenkings</surname>
              <given-names>KN</given-names>
            </name>
            <name name-style="western">
              <surname>Osbourne</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Robinson</surname>
              <given-names>AL</given-names>
            </name>
            <name name-style="western">
              <surname>Rogers</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Wilson</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Mair</surname>
              <given-names>FS</given-names>
            </name>
          </person-group>
          <article-title>Integrating telecare for chronic disease management in the community: what needs to be done?</article-title>
          <source>BMC Health Serv Res</source>
          <year>2011</year>
          <month>05</month>
          <day>27</day>
          <volume>11</volume>
          <issue>1</issue>
          <fpage>131</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmchealthservres.biomedcentral.com/articles/10.1186/1472-6963-11-131"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1472-6963-11-131</pub-id>
          <pub-id pub-id-type="medline">21619596</pub-id>
          <pub-id pub-id-type="pii">1472-6963-11-131</pub-id>
          <pub-id pub-id-type="pmcid">PMC3116473</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Arksey</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>O'Malley</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Scoping studies: towards a methodological framework</article-title>
          <source>Int J Soc Res Methodol</source>
          <year>2005</year>
          <month>02</month>
          <volume>8</volume>
          <issue>1</issue>
          <fpage>19</fpage>
          <lpage>32</lpage>
          <pub-id pub-id-type="doi">10.1080/1364557032000119616</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Levac</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Colquhoun</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>O'Brien</surname>
              <given-names>KK</given-names>
            </name>
          </person-group>
          <article-title>Scoping studies: advancing the methodology</article-title>
          <source>Implement Sci</source>
          <year>2010</year>
          <month>09</month>
          <day>20</day>
          <volume>5</volume>
          <issue>1</issue>
          <fpage>69</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://implementationscience.biomedcentral.com/articles/10.1186/1748-5908-5-69"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1748-5908-5-69</pub-id>
          <pub-id pub-id-type="medline">20854677</pub-id>
          <pub-id pub-id-type="pii">1748-5908-5-69</pub-id>
          <pub-id pub-id-type="pmcid">PMC2954944</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Page</surname>
              <given-names>MJ</given-names>
            </name>
            <name name-style="western">
              <surname>McKenzie</surname>
              <given-names>JE</given-names>
            </name>
            <name name-style="western">
              <surname>Bossuyt</surname>
              <given-names>PM</given-names>
            </name>
            <name name-style="western">
              <surname>Boutron</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Hoffmann</surname>
              <given-names>TC</given-names>
            </name>
            <name name-style="western">
              <surname>Mulrow</surname>
              <given-names>CD</given-names>
            </name>
            <name name-style="western">
              <surname>Shamseer</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Tetzlaff</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Akl</surname>
              <given-names>EA</given-names>
            </name>
            <name name-style="western">
              <surname>Brennan</surname>
              <given-names>SE</given-names>
            </name>
            <name name-style="western">
              <surname>Chou</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Glanville</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Grimshaw</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Hróbjartsson</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Lalu</surname>
              <given-names>MM</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Loder</surname>
              <given-names>EW</given-names>
            </name>
            <name name-style="western">
              <surname>Mayo-Wilson</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>McDonald</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>McGuinness</surname>
              <given-names>LA</given-names>
            </name>
            <name name-style="western">
              <surname>Stewart</surname>
              <given-names>LA</given-names>
            </name>
            <name name-style="western">
              <surname>Thomas</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Tricco</surname>
              <given-names>AC</given-names>
            </name>
            <name name-style="western">
              <surname>Welch</surname>
              <given-names>VA</given-names>
            </name>
            <name name-style="western">
              <surname>Whiting</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Moher</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>The PRISMA 2020 statement: an updated guideline for reporting systematic reviews</article-title>
          <source>BMJ</source>
          <year>2021</year>
          <month>03</month>
          <day>29</day>
          <volume>372</volume>
          <fpage>n71</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.bmj.com/lookup/pmidlookup?view=long&#38;pmid=33782057"/>
          </comment>
          <pub-id pub-id-type="doi">10.1136/bmj.n71</pub-id>
          <pub-id pub-id-type="medline">33782057</pub-id>
          <pub-id pub-id-type="pmcid">PMC8005924</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Babineau</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Product review: covidence (systematic review software)</article-title>
          <source>J Can Health Libr Assoc</source>
          <year>2014</year>
          <month>08</month>
          <day>01</day>
          <volume>35</volume>
          <issue>2</issue>
          <fpage>68</fpage>
          <lpage>71</lpage>
          <pub-id pub-id-type="doi">10.5596/c14-016</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mak</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Thomas</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Steps for conducting a scoping review</article-title>
          <source>J Grad Med Educ</source>
          <year>2022</year>
          <month>10</month>
          <volume>14</volume>
          <issue>5</issue>
          <fpage>565</fpage>
          <lpage>7</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/36274762"/>
          </comment>
          <pub-id pub-id-type="doi">10.4300/JGME-D-22-00621.1</pub-id>
          <pub-id pub-id-type="medline">36274762</pub-id>
          <pub-id pub-id-type="pmcid">PMC9580325</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ang</surname>
              <given-names>IY</given-names>
            </name>
            <name name-style="western">
              <surname>Tan</surname>
              <given-names>KX</given-names>
            </name>
            <name name-style="western">
              <surname>Tan</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Tan</surname>
              <given-names>CH</given-names>
            </name>
            <name name-style="western">
              <surname>Kwek</surname>
              <given-names>JW</given-names>
            </name>
            <name name-style="western">
              <surname>Tay</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Toh</surname>
              <given-names>SA</given-names>
            </name>
          </person-group>
          <article-title>A personalized mobile health program for type 2 diabetes during the COVID-19 pandemic: single-group pre-post study</article-title>
          <source>JMIR Diabetes</source>
          <year>2021</year>
          <month>07</month>
          <day>09</day>
          <volume>6</volume>
          <issue>3</issue>
          <fpage>e25820</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://diabetes.jmir.org/2021/3/e25820/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/25820</pub-id>
          <pub-id pub-id-type="medline">34111018</pub-id>
          <pub-id pub-id-type="pii">v6i3e25820</pub-id>
          <pub-id pub-id-type="pmcid">PMC8274679</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bergenstal</surname>
              <given-names>RM</given-names>
            </name>
            <name name-style="western">
              <surname>Layne</surname>
              <given-names>JE</given-names>
            </name>
            <name name-style="western">
              <surname>Zisser</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Gabbay</surname>
              <given-names>RA</given-names>
            </name>
            <name name-style="western">
              <surname>Barleen</surname>
              <given-names>NA</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>AA</given-names>
            </name>
            <name name-style="western">
              <surname>Majithia</surname>
              <given-names>AR</given-names>
            </name>
            <name name-style="western">
              <surname>Parkin</surname>
              <given-names>CG</given-names>
            </name>
            <name name-style="western">
              <surname>Dixon</surname>
              <given-names>RF</given-names>
            </name>
          </person-group>
          <article-title>Remote application and use of real-time continuous glucose monitoring by adults with type 2 diabetes in a virtual diabetes clinic</article-title>
          <source>Diabetes Technol Ther</source>
          <year>2021</year>
          <month>02</month>
          <day>01</day>
          <volume>23</volume>
          <issue>2</issue>
          <fpage>128</fpage>
          <lpage>32</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/33026839"/>
          </comment>
          <pub-id pub-id-type="doi">10.1089/dia.2020.0396</pub-id>
          <pub-id pub-id-type="medline">33026839</pub-id>
          <pub-id pub-id-type="pmcid">PMC7868574</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Berman</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>Guthrie</surname>
              <given-names>NL</given-names>
            </name>
            <name name-style="western">
              <surname>Edwards</surname>
              <given-names>KL</given-names>
            </name>
            <name name-style="western">
              <surname>Appelbaum</surname>
              <given-names>KJ</given-names>
            </name>
            <name name-style="western">
              <surname>Njike</surname>
              <given-names>VY</given-names>
            </name>
            <name name-style="western">
              <surname>Eisenberg</surname>
              <given-names>DM</given-names>
            </name>
            <name name-style="western">
              <surname>Katz</surname>
              <given-names>DL</given-names>
            </name>
          </person-group>
          <article-title>Change in glycemic control with use of a digital therapeutic in adults with type 2 diabetes: cohort study</article-title>
          <source>JMIR Diabetes</source>
          <year>2018</year>
          <month>02</month>
          <day>14</day>
          <volume>3</volume>
          <issue>1</issue>
          <fpage>e4</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://diabetes.jmir.org/2018/1/e4/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/diabetes.9591</pub-id>
          <pub-id pub-id-type="medline">30291074</pub-id>
          <pub-id pub-id-type="pii">v3i1e4</pub-id>
          <pub-id pub-id-type="pmcid">PMC6238888</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bradway</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Giordanengo</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Joakimsen</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Hansen</surname>
              <given-names>AH</given-names>
            </name>
            <name name-style="western">
              <surname>Grøttland</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Hartvigsen</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Randine</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Årsand</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Measuring the effects of sharing mobile health data during diabetes consultations: protocol for a mixed method study</article-title>
          <source>JMIR Res Protoc</source>
          <year>2020</year>
          <month>02</month>
          <day>10</day>
          <volume>9</volume>
          <issue>2</issue>
          <fpage>e16657</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.researchprotocols.org/2020/2/e16657/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/16657</pub-id>
          <pub-id pub-id-type="medline">32039818</pub-id>
          <pub-id pub-id-type="pii">v9i2e16657</pub-id>
          <pub-id pub-id-type="pmcid">PMC7055770</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cassidy</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Okwose</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Scragg</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Houghton</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Ashley</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Trenell</surname>
              <given-names>MI</given-names>
            </name>
            <name name-style="western">
              <surname>Jakovljevic</surname>
              <given-names>DG</given-names>
            </name>
            <name name-style="western">
              <surname>Hallsworth</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Avery</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Assessing the feasibility and acceptability of changing health for the management of prediabetes: protocol for a pilot study of a digital behavioural intervention</article-title>
          <source>Pilot Feasibility Stud</source>
          <year>2019</year>
          <month>11</month>
          <day>26</day>
          <volume>5</volume>
          <issue>1</issue>
          <fpage>139</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://pilotfeasibilitystudies.biomedcentral.com/articles/10.1186/s40814-019-0519-1"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s40814-019-0519-1</pub-id>
          <pub-id pub-id-type="medline">31788325</pub-id>
          <pub-id pub-id-type="pii">519</pub-id>
          <pub-id pub-id-type="pmcid">PMC6878649</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Doocy</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Paik</surname>
              <given-names>KE</given-names>
            </name>
            <name name-style="western">
              <surname>Lyles</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Hei Tam</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Fahed</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Winkler</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Kontunen</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Mkanna</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Burnham</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Guidelines and mHealth to improve quality of hypertension and type 2 diabetes care for vulnerable populations in Lebanon: longitudinal cohort study</article-title>
          <source>JMIR Mhealth Uhealth</source>
          <year>2017</year>
          <month>10</month>
          <day>18</day>
          <volume>5</volume>
          <issue>10</issue>
          <fpage>e158</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mhealth.jmir.org/2017/10/e158/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/mhealth.7745</pub-id>
          <pub-id pub-id-type="medline">29046266</pub-id>
          <pub-id pub-id-type="pii">v5i10e158</pub-id>
          <pub-id pub-id-type="pmcid">PMC5695979</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Haste</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Adamson</surname>
              <given-names>AJ</given-names>
            </name>
            <name name-style="western">
              <surname>McColl</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Araujo-Soares</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Bell</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>Web-based weight loss intervention for men with type 2 diabetes: pilot randomized controlled trial</article-title>
          <source>JMIR Diabetes</source>
          <year>2017</year>
          <month>07</month>
          <day>07</day>
          <volume>2</volume>
          <issue>2</issue>
          <fpage>e14</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://diabetes.jmir.org/2017/2/e14/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/diabetes.7430</pub-id>
          <pub-id pub-id-type="medline">30291100</pub-id>
          <pub-id pub-id-type="pii">v2i2e14</pub-id>
          <pub-id pub-id-type="pmcid">PMC6238853</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Iljaž</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Brodnik</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Zrimec</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Cukjati</surname>
              <given-names>I</given-names>
            </name>
          </person-group>
          <article-title>E-healthcare for diabetes mellitus type 2 patients - a randomised controlled trial in Slovenia</article-title>
          <source>Zdr Varst</source>
          <year>2017</year>
          <month>09</month>
          <volume>56</volume>
          <issue>3</issue>
          <fpage>150</fpage>
          <lpage>7</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/28713443"/>
          </comment>
          <pub-id pub-id-type="doi">10.1515/sjph-2017-0020</pub-id>
          <pub-id pub-id-type="medline">28713443</pub-id>
          <pub-id pub-id-type="pii">sjph-2017-0020</pub-id>
          <pub-id pub-id-type="pmcid">PMC5504540</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Jeon</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>HA</given-names>
            </name>
          </person-group>
          <article-title>Experiences of patients with a diabetes self-care app developed based on the information-motivation-behavioral skills model: before-and-after study</article-title>
          <source>JMIR Diabetes</source>
          <year>2019</year>
          <month>04</month>
          <day>18</day>
          <volume>4</volume>
          <issue>2</issue>
          <fpage>e11590</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://diabetes.jmir.org/2019/2/e11590/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/11590</pub-id>
          <pub-id pub-id-type="medline">30998218</pub-id>
          <pub-id pub-id-type="pii">v4i2e11590</pub-id>
          <pub-id pub-id-type="pmcid">PMC6495295</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Johnston</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Monitoring of blood glucose levels, ketones and insulin bolus advice using 4SURE products and app-based technology</article-title>
          <source>Br J Nurs</source>
          <year>2022</year>
          <month>01</month>
          <day>13</day>
          <volume>31</volume>
          <issue>1</issue>
          <fpage>34</fpage>
          <lpage>9</lpage>
          <pub-id pub-id-type="doi">10.12968/bjon.2022.31.1.34</pub-id>
          <pub-id pub-id-type="medline">35019739</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Jung</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Demiris</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Tarczy-Hornoch</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Zachry</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>A novel food record app for dietary assessments among older adults with type 2 diabetes: development and usability study</article-title>
          <source>JMIR Form Res</source>
          <year>2021</year>
          <month>02</month>
          <day>17</day>
          <volume>5</volume>
          <issue>2</issue>
          <fpage>e14760</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://formative.jmir.org/2021/2/e14760/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/14760</pub-id>
          <pub-id pub-id-type="medline">33493129</pub-id>
          <pub-id pub-id-type="pii">v5i2e14760</pub-id>
          <pub-id pub-id-type="pmcid">PMC7929750</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kempf</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Altpeter</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Berger</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Reuß</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Fuchs</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Schneider</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Gärtner</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Niedermeier</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Martin</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Efficacy of the telemedical lifestyle intervention program TeLiPro in advanced stages of type 2 diabetes: a randomized controlled trial</article-title>
          <source>Diabetes Care</source>
          <year>2017</year>
          <month>07</month>
          <volume>40</volume>
          <issue>7</issue>
          <fpage>863</fpage>
          <lpage>71</lpage>
          <pub-id pub-id-type="doi">10.2337/dc17-0303</pub-id>
          <pub-id pub-id-type="medline">28500214</pub-id>
          <pub-id pub-id-type="pii">dc17-0303</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>DY</given-names>
            </name>
            <name name-style="western">
              <surname>Yoo</surname>
              <given-names>SH</given-names>
            </name>
            <name name-style="western">
              <surname>Min</surname>
              <given-names>KP</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>CY</given-names>
            </name>
          </person-group>
          <article-title>Effect of voluntary participation on mobile health care in diabetes management: randomized controlled open-label trial</article-title>
          <source>JMIR Mhealth Uhealth</source>
          <year>2020</year>
          <month>09</month>
          <day>18</day>
          <volume>8</volume>
          <issue>9</issue>
          <fpage>e19153</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mhealth.jmir.org/2020/9/e19153/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/19153</pub-id>
          <pub-id pub-id-type="medline">32945775</pub-id>
          <pub-id pub-id-type="pii">v8i9e19153</pub-id>
          <pub-id pub-id-type="pmcid">PMC7532462</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kobayashi</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Tsushita</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Nomura</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Muramoto</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Kato</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Eguchi</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Onoue</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Goto</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Muto</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Yatsuya</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Arima</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Automated feedback messages with Shichifukujin characters using IoT system-improved glycemic control in people with diabetes: a prospective, multicenter randomized controlled trial</article-title>
          <source>J Diabetes Sci Technol</source>
          <year>2019</year>
          <month>07</month>
          <day>20</day>
          <volume>13</volume>
          <issue>4</issue>
          <fpage>796</fpage>
          <lpage>8</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/31104490"/>
          </comment>
          <pub-id pub-id-type="doi">10.1177/1932296819851785</pub-id>
          <pub-id pub-id-type="medline">31104490</pub-id>
          <pub-id pub-id-type="pmcid">PMC6610601</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Koot</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Goh</surname>
              <given-names>PS</given-names>
            </name>
            <name name-style="western">
              <surname>Lim</surname>
              <given-names>RS</given-names>
            </name>
            <name name-style="western">
              <surname>Tian</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Yau</surname>
              <given-names>TY</given-names>
            </name>
            <name name-style="western">
              <surname>Tan</surname>
              <given-names>NC</given-names>
            </name>
            <name name-style="western">
              <surname>Finkelstein</surname>
              <given-names>EA</given-names>
            </name>
          </person-group>
          <article-title>A mobile lifestyle management program (GlycoLeap) for people with type 2 diabetes: single-arm feasibility study</article-title>
          <source>JMIR Mhealth Uhealth</source>
          <year>2019</year>
          <month>05</month>
          <day>24</day>
          <volume>7</volume>
          <issue>5</issue>
          <fpage>e12965</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mhealth.jmir.org/2019/5/e12965/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/12965</pub-id>
          <pub-id pub-id-type="medline">31127720</pub-id>
          <pub-id pub-id-type="pii">v7i5e12965</pub-id>
          <pub-id pub-id-type="pmcid">PMC6555118</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ku</surname>
              <given-names>EJ</given-names>
            </name>
            <name name-style="western">
              <surname>Park</surname>
              <given-names>JI</given-names>
            </name>
            <name name-style="western">
              <surname>Jeon</surname>
              <given-names>HJ</given-names>
            </name>
            <name name-style="western">
              <surname>Oh</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Choi</surname>
              <given-names>HJ</given-names>
            </name>
          </person-group>
          <article-title>Clinical efficacy and plausibility of a smartphone-based integrated online real-time diabetes care system via glucose and diet data management: a pilot study</article-title>
          <source>Intern Med J</source>
          <year>2020</year>
          <month>12</month>
          <day>22</day>
          <volume>50</volume>
          <issue>12</issue>
          <fpage>1524</fpage>
          <lpage>32</lpage>
          <pub-id pub-id-type="doi">10.1111/imj.14738</pub-id>
          <pub-id pub-id-type="medline">31904890</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lamprinos</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Demski</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Mantwill</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Kabak</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Hildebrand</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Ploessnig</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Modular ICT-based patient empowerment framework for self-management of diabetes: design perspectives and validation results</article-title>
          <source>Int J Med Inform</source>
          <year>2016</year>
          <month>07</month>
          <volume>91</volume>
          <fpage>31</fpage>
          <lpage>43</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ijmedinf.2016.04.006</pub-id>
          <pub-id pub-id-type="medline">27185507</pub-id>
          <pub-id pub-id-type="pii">S1386-5056(16)30055-7</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lim</surname>
              <given-names>SL</given-names>
            </name>
            <name name-style="western">
              <surname>Ong</surname>
              <given-names>KW</given-names>
            </name>
            <name name-style="western">
              <surname>Johal</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Han</surname>
              <given-names>CY</given-names>
            </name>
            <name name-style="western">
              <surname>Yap</surname>
              <given-names>QV</given-names>
            </name>
            <name name-style="western">
              <surname>Chan</surname>
              <given-names>YH</given-names>
            </name>
            <name name-style="western">
              <surname>Chooi</surname>
              <given-names>YC</given-names>
            </name>
            <name name-style="western">
              <surname>Zhang</surname>
              <given-names>ZP</given-names>
            </name>
            <name name-style="western">
              <surname>Chandra</surname>
              <given-names>CC</given-names>
            </name>
            <name name-style="western">
              <surname>Thiagarajah</surname>
              <given-names>AG</given-names>
            </name>
            <name name-style="western">
              <surname>Khoo</surname>
              <given-names>CM</given-names>
            </name>
          </person-group>
          <article-title>Effect of a smartphone app on weight change and metabolic outcomes in Asian adults with type 2 diabetes: a randomized clinical trial</article-title>
          <source>JAMA Netw Open</source>
          <year>2021</year>
          <month>06</month>
          <day>01</day>
          <volume>4</volume>
          <issue>6</issue>
          <fpage>e2112417</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/34081137"/>
          </comment>
          <pub-id pub-id-type="doi">10.1001/jamanetworkopen.2021.12417</pub-id>
          <pub-id pub-id-type="medline">34081137</pub-id>
          <pub-id pub-id-type="pii">2780570</pub-id>
          <pub-id pub-id-type="pmcid">PMC8176331</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Liu</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Yu</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Sun</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Treatment effect of type 2 diabetes patients in outpatient department based on blockchain electronic mobile medical app</article-title>
          <source>J Healthc Eng</source>
          <year>2021</year>
          <month>3</month>
          <day>1</day>
          <volume>2021</volume>
          <fpage>6693810</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1155/2021/6693810"/>
          </comment>
          <pub-id pub-id-type="doi">10.1155/2021/6693810</pub-id>
          <pub-id pub-id-type="medline">33728034</pub-id>
          <pub-id pub-id-type="pmcid">PMC7939747</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>McKenzie</surname>
              <given-names>AL</given-names>
            </name>
            <name name-style="western">
              <surname>Hallberg</surname>
              <given-names>SJ</given-names>
            </name>
            <name name-style="western">
              <surname>Creighton</surname>
              <given-names>BC</given-names>
            </name>
            <name name-style="western">
              <surname>Volk</surname>
              <given-names>BM</given-names>
            </name>
            <name name-style="western">
              <surname>Link</surname>
              <given-names>TM</given-names>
            </name>
            <name name-style="western">
              <surname>Abner</surname>
              <given-names>MK</given-names>
            </name>
            <name name-style="western">
              <surname>Glon</surname>
              <given-names>RM</given-names>
            </name>
            <name name-style="western">
              <surname>McCarter</surname>
              <given-names>JP</given-names>
            </name>
            <name name-style="western">
              <surname>Volek</surname>
              <given-names>JS</given-names>
            </name>
            <name name-style="western">
              <surname>Phinney</surname>
              <given-names>SD</given-names>
            </name>
          </person-group>
          <article-title>A novel intervention including individualized nutritional recommendations reduces hemoglobin A1c level, medication use, and weight in type 2 diabetes</article-title>
          <source>JMIR Diabetes</source>
          <year>2017</year>
          <month>03</month>
          <day>07</day>
          <volume>2</volume>
          <issue>1</issue>
          <fpage>e5</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://diabetes.jmir.org/2017/1/e5/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/diabetes.6981</pub-id>
          <pub-id pub-id-type="medline">30291062</pub-id>
          <pub-id pub-id-type="pii">v2i1e5</pub-id>
          <pub-id pub-id-type="pmcid">PMC6238887</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Modave</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Bian</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Rosenberg</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Mendoza</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Liang</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Bhosale</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Maeztu</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Rodriguez</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Cardel</surname>
              <given-names>MI</given-names>
            </name>
          </person-group>
          <article-title>DiaFit: the development of a smart app for patients with type 2 diabetes and obesity</article-title>
          <source>JMIR Diabetes</source>
          <year>2016</year>
          <month>12</month>
          <day>13</day>
          <volume>1</volume>
          <issue>2</issue>
          <fpage>e5</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://diabetes.jmir.org/2016/2//"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/diabetes.6662</pub-id>
          <pub-id pub-id-type="medline">29388609</pub-id>
          <pub-id pub-id-type="pii">e5</pub-id>
          <pub-id pub-id-type="pmcid">PMC5788459</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Polonsky</surname>
              <given-names>WH</given-names>
            </name>
            <name name-style="western">
              <surname>Layne</surname>
              <given-names>JE</given-names>
            </name>
            <name name-style="western">
              <surname>Parkin</surname>
              <given-names>CG</given-names>
            </name>
            <name name-style="western">
              <surname>Kusiak</surname>
              <given-names>CM</given-names>
            </name>
            <name name-style="western">
              <surname>Barleen</surname>
              <given-names>NA</given-names>
            </name>
            <name name-style="western">
              <surname>Miller</surname>
              <given-names>DP</given-names>
            </name>
            <name name-style="western">
              <surname>Zisser</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Dixon</surname>
              <given-names>RF</given-names>
            </name>
          </person-group>
          <article-title>Impact of participation in a virtual diabetes clinic on diabetes-related distress in individuals with type 2 diabetes</article-title>
          <source>Clin Diabetes</source>
          <year>2020</year>
          <month>10</month>
          <volume>38</volume>
          <issue>4</issue>
          <fpage>357</fpage>
          <lpage>62</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/33132505"/>
          </comment>
          <pub-id pub-id-type="doi">10.2337/cd19-0105</pub-id>
          <pub-id pub-id-type="medline">33132505</pub-id>
          <pub-id pub-id-type="pii">CD190105</pub-id>
          <pub-id pub-id-type="pmcid">PMC7566922</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Quinn</surname>
              <given-names>CC</given-names>
            </name>
            <name name-style="western">
              <surname>Butler</surname>
              <given-names>EC</given-names>
            </name>
            <name name-style="western">
              <surname>Swasey</surname>
              <given-names>KK</given-names>
            </name>
            <name name-style="western">
              <surname>Shardell</surname>
              <given-names>MD</given-names>
            </name>
            <name name-style="western">
              <surname>Terrin</surname>
              <given-names>MD</given-names>
            </name>
            <name name-style="western">
              <surname>Barr</surname>
              <given-names>EA</given-names>
            </name>
            <name name-style="western">
              <surname>Gruber-Baldini</surname>
              <given-names>AL</given-names>
            </name>
          </person-group>
          <article-title>Mobile diabetes intervention study of patient engagement and impact on blood glucose: mixed methods analysis</article-title>
          <source>JMIR Mhealth Uhealth</source>
          <year>2018</year>
          <month>02</month>
          <day>02</day>
          <volume>6</volume>
          <issue>2</issue>
          <fpage>e31</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mhealth.jmir.org/2018/2/e31/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/mhealth.9265</pub-id>
          <pub-id pub-id-type="medline">29396389</pub-id>
          <pub-id pub-id-type="pii">v6i2e31</pub-id>
          <pub-id pub-id-type="pmcid">PMC5816260</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Salari</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>R Niakan Kalhori</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>GhaziSaeedi</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Jeddi</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Nazari</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Fatehi</surname>
              <given-names>F</given-names>
            </name>
          </person-group>
          <article-title>Mobile-based and cloud-based system for self-management of people with type 2 diabetes: development and usability evaluation</article-title>
          <source>J Med Internet Res</source>
          <year>2021</year>
          <month>06</month>
          <day>02</day>
          <volume>23</volume>
          <issue>6</issue>
          <fpage>e18167</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2021/6/e18167/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/18167</pub-id>
          <pub-id pub-id-type="medline">34076579</pub-id>
          <pub-id pub-id-type="pii">v23i6e18167</pub-id>
          <pub-id pub-id-type="pmcid">PMC8209530</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Schmocker</surname>
              <given-names>KS</given-names>
            </name>
            <name name-style="western">
              <surname>Zwahlen</surname>
              <given-names>FS</given-names>
            </name>
            <name name-style="western">
              <surname>Denecke</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Mobile app for simplifying life with diabetes: technical description and usability study of GlucoMan</article-title>
          <source>JMIR Diabetes</source>
          <year>2018</year>
          <month>02</month>
          <day>26</day>
          <volume>3</volume>
          <issue>1</issue>
          <fpage>e6</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://diabetes.jmir.org/2018/1/e6/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/diabetes.8160</pub-id>
          <pub-id pub-id-type="medline">30291070</pub-id>
          <pub-id pub-id-type="pii">v3i1e6</pub-id>
          <pub-id pub-id-type="pmcid">PMC6238891</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Schusterbauer</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Feitek</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Kastner</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Toplak</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Two-stage evaluation of a telehealth nutrition management service in support of diabesity therapy</article-title>
          <source>Stud Health Technol Inform</source>
          <year>2018</year>
          <volume>248</volume>
          <fpage>314</fpage>
          <lpage>21</lpage>
          <pub-id pub-id-type="medline">29726453</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Seah</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Jiang</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Lopez</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Tan</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Lim</surname>
              <given-names>ST</given-names>
            </name>
            <name name-style="western">
              <surname>Ren</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Khoo</surname>
              <given-names>YH</given-names>
            </name>
          </person-group>
          <article-title>A randomized controlled trial on a nurse-led smartphone-based self-management programme for people with poorly controlled type 2 diabetes: a study protocol</article-title>
          <source>J Adv Nurs</source>
          <year>2018</year>
          <month>01</month>
          <volume>74</volume>
          <issue>1</issue>
          <fpage>190</fpage>
          <lpage>200</lpage>
          <pub-id pub-id-type="doi">10.1111/jan.13394</pub-id>
          <pub-id pub-id-type="medline">28727183</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Zaharia</surname>
              <given-names>OP</given-names>
            </name>
            <name name-style="western">
              <surname>Kupriyanova</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Karusheva</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Markgraf</surname>
              <given-names>DF</given-names>
            </name>
            <name name-style="western">
              <surname>Kantartzis</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Birkenfeld</surname>
              <given-names>AL</given-names>
            </name>
            <name name-style="western">
              <surname>Trenell</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Sahasranaman</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Cheyette</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Kössler</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Bódis</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Burkart</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Hwang</surname>
              <given-names>JH</given-names>
            </name>
            <name name-style="western">
              <surname>Roden</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Szendroedi</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Pesta</surname>
              <given-names>DH</given-names>
            </name>
          </person-group>
          <article-title>Improving insulin sensitivity, liver steatosis and fibrosis in type 2 diabetes by a food-based digital education-assisted lifestyle intervention program: a feasibility study</article-title>
          <source>Eur J Nutr</source>
          <year>2021</year>
          <month>10</month>
          <volume>60</volume>
          <issue>7</issue>
          <fpage>3811</fpage>
          <lpage>8</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/33839905"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s00394-021-02521-3</pub-id>
          <pub-id pub-id-type="medline">33839905</pub-id>
          <pub-id pub-id-type="pii">10.1007/s00394-021-02521-3</pub-id>
          <pub-id pub-id-type="pmcid">PMC8437928</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bastyr</surname>
              <given-names>EJ 3rd</given-names>
            </name>
            <name name-style="western">
              <surname>Zhang</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Mou</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Hackett</surname>
              <given-names>AP</given-names>
            </name>
            <name name-style="western">
              <surname>Raymond</surname>
              <given-names>SA</given-names>
            </name>
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>AM</given-names>
            </name>
          </person-group>
          <article-title>Performance of an electronic diary system for intensive insulin management in global diabetes clinical trials</article-title>
          <source>Diabetes Technol Ther</source>
          <year>2015</year>
          <month>08</month>
          <volume>17</volume>
          <issue>8</issue>
          <fpage>571</fpage>
          <lpage>9</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/25826466"/>
          </comment>
          <pub-id pub-id-type="doi">10.1089/dia.2014.0407</pub-id>
          <pub-id pub-id-type="medline">25826466</pub-id>
          <pub-id pub-id-type="pmcid">PMC4529073</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Levy</surname>
              <given-names>NK</given-names>
            </name>
            <name name-style="western">
              <surname>Moynihan</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Nilo</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Singer</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Etiebet</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>Bernik</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Cho</surname>
              <given-names>JH</given-names>
            </name>
            <name name-style="western">
              <surname>Fang</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Natarajan</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>The mobile insulin titration intervention (MITI) study: innovative chronic disease management of diabetes</article-title>
          <source>J Gen Internal Med</source>
          <year>2015</year>
          <volume>30</volume>
          <fpage>S547</fpage>
          <lpage>8</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Tang</surname>
              <given-names>PC</given-names>
            </name>
            <name name-style="western">
              <surname>Overhage</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Chan</surname>
              <given-names>AS</given-names>
            </name>
            <name name-style="western">
              <surname>Brown</surname>
              <given-names>NL</given-names>
            </name>
            <name name-style="western">
              <surname>Aghighi</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Entwistle</surname>
              <given-names>MP</given-names>
            </name>
            <name name-style="western">
              <surname>Hui</surname>
              <given-names>SL</given-names>
            </name>
            <name name-style="western">
              <surname>Hyde</surname>
              <given-names>SM</given-names>
            </name>
            <name name-style="western">
              <surname>Klieman</surname>
              <given-names>LH</given-names>
            </name>
            <name name-style="western">
              <surname>Mitchell</surname>
              <given-names>CJ</given-names>
            </name>
            <name name-style="western">
              <surname>Perkins</surname>
              <given-names>AJ</given-names>
            </name>
            <name name-style="western">
              <surname>Qureshi</surname>
              <given-names>LS</given-names>
            </name>
            <name name-style="western">
              <surname>Waltimyer</surname>
              <given-names>TA</given-names>
            </name>
            <name name-style="western">
              <surname>Winters</surname>
              <given-names>LJ</given-names>
            </name>
            <name name-style="western">
              <surname>Young</surname>
              <given-names>CY</given-names>
            </name>
          </person-group>
          <article-title>Online disease management of diabetes: engaging and motivating patients online with enhanced resources-diabetes (EMPOWER-D), a randomized controlled trial</article-title>
          <source>J Am Med Inform Assoc</source>
          <year>2013</year>
          <month>05</month>
          <day>01</day>
          <volume>20</volume>
          <issue>3</issue>
          <fpage>526</fpage>
          <lpage>34</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/23171659"/>
          </comment>
          <pub-id pub-id-type="doi">10.1136/amiajnl-2012-001263</pub-id>
          <pub-id pub-id-type="medline">23171659</pub-id>
          <pub-id pub-id-type="pii">amiajnl-2012-001263</pub-id>
          <pub-id pub-id-type="pmcid">PMC3628059</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chung</surname>
              <given-names>YS</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>CH</given-names>
            </name>
          </person-group>
          <article-title>Effectiveness of the smart care service for diabetes management</article-title>
          <source>Healthc Inform Res</source>
          <year>2014</year>
          <month>10</month>
          <volume>20</volume>
          <issue>4</issue>
          <fpage>288</fpage>
          <lpage>94</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/25405065"/>
          </comment>
          <pub-id pub-id-type="doi">10.4258/hir.2014.20.4.288</pub-id>
          <pub-id pub-id-type="medline">25405065</pub-id>
          <pub-id pub-id-type="pmcid">PMC4231179</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Seo</surname>
              <given-names>JM</given-names>
            </name>
          </person-group>
          <article-title>Integrated diabetes self-management program using smartphone application: a randomized controlled trial</article-title>
          <source>West J Nurs Res</source>
          <year>2022</year>
          <month>04</month>
          <day>03</day>
          <volume>44</volume>
          <issue>4</issue>
          <fpage>383</fpage>
          <lpage>94</lpage>
          <pub-id pub-id-type="doi">10.1177/0193945921994912</pub-id>
          <pub-id pub-id-type="medline">33655794</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Torbjørnsen</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Jenum</surname>
              <given-names>AK</given-names>
            </name>
            <name name-style="western">
              <surname>Småstuen</surname>
              <given-names>MC</given-names>
            </name>
            <name name-style="western">
              <surname>Arsand</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Holmen</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Wahl</surname>
              <given-names>AK</given-names>
            </name>
            <name name-style="western">
              <surname>Ribu</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>A low-intensity mobile health intervention with and without health counseling for persons with type 2 diabetes, part 1: baseline and short-term results from a randomized controlled trial in the Norwegian part of renewing health</article-title>
          <source>JMIR Mhealth Uhealth</source>
          <year>2014</year>
          <month>12</month>
          <day>11</day>
          <volume>2</volume>
          <issue>4</issue>
          <fpage>e52</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mhealth.jmir.org/2014/4/e52/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/mhealth.3535</pub-id>
          <pub-id pub-id-type="medline">25499592</pub-id>
          <pub-id pub-id-type="pii">v2i4e52</pub-id>
          <pub-id pub-id-type="pmcid">PMC4275473</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nes</surname>
              <given-names>AA</given-names>
            </name>
            <name name-style="western">
              <surname>van Dulmen</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Eide</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Finset</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Kristjánsdóttir</surname>
              <given-names>OB</given-names>
            </name>
            <name name-style="western">
              <surname>Steen</surname>
              <given-names>IS</given-names>
            </name>
            <name name-style="western">
              <surname>Eide</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>The development and feasibility of a web-based intervention with diaries and situational feedback via smartphone to support self-management in patients with diabetes type 2</article-title>
          <source>Diabetes Res Clin Pract</source>
          <year>2012</year>
          <month>09</month>
          <volume>97</volume>
          <issue>3</issue>
          <fpage>385</fpage>
          <lpage>93</lpage>
          <pub-id pub-id-type="doi">10.1016/j.diabres.2012.04.019</pub-id>
          <pub-id pub-id-type="medline">22578890</pub-id>
          <pub-id pub-id-type="pii">S0168-8227(12)00153-2</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref64">
        <label>64</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Jia</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Zhang</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Duolikun</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Zhu</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Bao</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Liu</surname>
              <given-names>Y</given-names>
            </name>
          </person-group>
          <article-title>Study protocol for the road to hierarchical diabetes management at primary care (ROADMAP) study in China: a cluster randomised controlled trial</article-title>
          <source>BMJ Open</source>
          <year>2020</year>
          <month>01</month>
          <day>06</day>
          <volume>10</volume>
          <issue>1</issue>
          <fpage>e032734</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmjopen.bmj.com/lookup/pmidlookup?view=long&#38;pmid=31911516"/>
          </comment>
          <pub-id pub-id-type="doi">10.1136/bmjopen-2019-032734</pub-id>
          <pub-id pub-id-type="medline">31911516</pub-id>
          <pub-id pub-id-type="pii">bmjopen-2019-032734</pub-id>
          <pub-id pub-id-type="pmcid">PMC6955560</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref65">
        <label>65</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Esau</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Koen</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Herselman</surname>
              <given-names>MG</given-names>
            </name>
          </person-group>
          <article-title>Adaptation of the RenalSmart® web-based application for the dietary management of patients with diabetic nephropathy</article-title>
          <source>South Afr J Clin Nutr</source>
          <year>2016</year>
          <month>05</month>
          <day>31</day>
          <volume>26</volume>
          <issue>3</issue>
          <fpage>132</fpage>
          <lpage>40</lpage>
          <pub-id pub-id-type="doi">10.1080/16070658.2013.11734457</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref66">
        <label>66</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Hidalgo</surname>
              <given-names>JI</given-names>
            </name>
            <name name-style="western">
              <surname>Maqueda</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Risco-Martín</surname>
              <given-names>JL</given-names>
            </name>
            <name name-style="western">
              <surname>Cuesta-Infante</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Colmenar</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Nobel</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>glUCModel: a monitoring and modeling system for chronic diseases applied to diabetes</article-title>
          <source>J Biomed Inform</source>
          <year>2014</year>
          <month>04</month>
          <volume>48</volume>
          <fpage>183</fpage>
          <lpage>92</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S1532-0464(13)00206-2"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.jbi.2013.12.015</pub-id>
          <pub-id pub-id-type="medline">24407050</pub-id>
          <pub-id pub-id-type="pii">S1532-0464(13)00206-2</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref67">
        <label>67</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Castelnuovo</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Manzoni</surname>
              <given-names>GM</given-names>
            </name>
            <name name-style="western">
              <surname>Cuzziol</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Cesa</surname>
              <given-names>GL</given-names>
            </name>
            <name name-style="western">
              <surname>Tuzzi</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Villa</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Liuzzi</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Petroni</surname>
              <given-names>ML</given-names>
            </name>
            <name name-style="western">
              <surname>Molinari</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>TECNOB: study design of a randomized controlled trial of a multidisciplinary telecare intervention for obese patients with type-2 diabetes</article-title>
          <source>BMC Public Health</source>
          <year>2010</year>
          <month>04</month>
          <day>23</day>
          <volume>10</volume>
          <issue>1</issue>
          <fpage>204</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-10-204"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1471-2458-10-204</pub-id>
          <pub-id pub-id-type="medline">20416042</pub-id>
          <pub-id pub-id-type="pii">1471-2458-10-204</pub-id>
          <pub-id pub-id-type="pmcid">PMC2873580</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref68">
        <label>68</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Chuang</surname>
              <given-names>LM</given-names>
            </name>
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>CH</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>CS</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>IC</given-names>
            </name>
            <name name-style="western">
              <surname>Chung</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Peng</surname>
              <given-names>HY</given-names>
            </name>
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>HC</given-names>
            </name>
            <name name-style="western">
              <surname>Hsu</surname>
              <given-names>YL</given-names>
            </name>
            <name name-style="western">
              <surname>Lin</surname>
              <given-names>YS</given-names>
            </name>
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>HJ</given-names>
            </name>
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>TC</given-names>
            </name>
            <name name-style="western">
              <surname>Jiang</surname>
              <given-names>YD</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>HC</given-names>
            </name>
            <name name-style="western">
              <surname>Tan</surname>
              <given-names>CT</given-names>
            </name>
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>HL</given-names>
            </name>
            <name name-style="western">
              <surname>Lai</surname>
              <given-names>F</given-names>
            </name>
          </person-group>
          <article-title>Evaluating self-management behaviors of diabetic patients in a telehealthcare program: longitudinal study over 18 months</article-title>
          <source>J Med Internet Res</source>
          <year>2013</year>
          <month>12</month>
          <day>09</day>
          <volume>15</volume>
          <issue>12</issue>
          <fpage>e266</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2013/12/e266/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.2699</pub-id>
          <pub-id pub-id-type="medline">24323283</pub-id>
          <pub-id pub-id-type="pii">v15i12e266</pub-id>
          <pub-id pub-id-type="pmcid">PMC3869106</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref69">
        <label>69</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Holmen</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Torbjørnsen</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Wahl</surname>
              <given-names>AK</given-names>
            </name>
            <name name-style="western">
              <surname>Jenum</surname>
              <given-names>AK</given-names>
            </name>
            <name name-style="western">
              <surname>Småstuen</surname>
              <given-names>MC</given-names>
            </name>
            <name name-style="western">
              <surname>Arsand</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Ribu</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>A mobile health intervention for self-management and lifestyle change for persons with type 2 diabetes, part 2: one-year results from the Norwegian randomized controlled trial renewing health</article-title>
          <source>JMIR Mhealth Uhealth</source>
          <year>2014</year>
          <month>12</month>
          <day>11</day>
          <volume>2</volume>
          <issue>4</issue>
          <fpage>e57</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mhealth.jmir.org/2014/4/e57/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/mhealth.3882</pub-id>
          <pub-id pub-id-type="medline">25499872</pub-id>
          <pub-id pub-id-type="pii">v2i4e57</pub-id>
          <pub-id pub-id-type="pmcid">PMC4275495</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref70">
        <label>70</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>AR</given-names>
            </name>
            <name name-style="western">
              <surname>Bailey-Davis</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Yule</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Kwiecen</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Graboski</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Juraschek</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Krekel</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Collins</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Anderson</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Abstract P289: effects of dietary app-supported tele-counseling on sodium intake, diet quality, and blood pressure in patients with diabetes and kidney disease</article-title>
          <source>Circulation</source>
          <year>2019</year>
          <month>03</month>
          <day>05</day>
          <volume>139</volume>
          <issue>Suppl_1</issue>
          <fpage>AP289</fpage>
          <pub-id pub-id-type="doi">10.1161/circ.139.suppl_1.p289</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref71">
        <label>71</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bradway</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Pfuhl</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Joakimsen</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Ribu</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Grøttland</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Årsand</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Analysing mHealth usage logs in RCTs: explaining participants' interactions with type 2 diabetes self-management tools</article-title>
          <source>PLoS One</source>
          <year>2018</year>
          <month>8</month>
          <day>30</day>
          <volume>13</volume>
          <issue>8</issue>
          <fpage>e0203202</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0203202"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0203202</pub-id>
          <pub-id pub-id-type="medline">30161248</pub-id>
          <pub-id pub-id-type="pii">PONE-D-18-17450</pub-id>
          <pub-id pub-id-type="pmcid">PMC6117049</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref72">
        <label>72</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Castelnuovo</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Manzoni</surname>
              <given-names>GM</given-names>
            </name>
            <name name-style="western">
              <surname>Cuzziol</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Cesa</surname>
              <given-names>GL</given-names>
            </name>
            <name name-style="western">
              <surname>Corti</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Tuzzi</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Villa</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Liuzzi</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Petroni</surname>
              <given-names>ML</given-names>
            </name>
            <name name-style="western">
              <surname>Molinari</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>TECNOB study: ad interim results of a randomized controlled trial of a multidisciplinary telecare intervention for obese patients with type-2 diabetes</article-title>
          <source>Clin Pract Epidemiol Ment Health</source>
          <year>2011</year>
          <month>03</month>
          <day>04</day>
          <volume>7</volume>
          <issue>1</issue>
          <fpage>44</fpage>
          <lpage>50</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/21559233"/>
          </comment>
          <pub-id pub-id-type="doi">10.2174/1745017901107010044</pub-id>
          <pub-id pub-id-type="medline">21559233</pub-id>
          <pub-id pub-id-type="pii">CPEMH-7-44</pub-id>
          <pub-id pub-id-type="pmcid">PMC3089038</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref73">
        <label>73</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bird</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Oldenburg</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Cassimatis</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Russell</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Ash</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Courtney</surname>
              <given-names>MD</given-names>
            </name>
            <name name-style="western">
              <surname>Scuffham</surname>
              <given-names>PA</given-names>
            </name>
            <name name-style="western">
              <surname>Stewart</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Wootton</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Friedman</surname>
              <given-names>RH</given-names>
            </name>
          </person-group>
          <article-title>Randomised controlled trial of an automated, interactive telephone intervention to improve type 2 diabetes self-management (Telephone-Linked Care Diabetes Project): study protocol</article-title>
          <source>BMC Public Health</source>
          <year>2010</year>
          <month>10</month>
          <day>12</day>
          <volume>10</volume>
          <issue>1</issue>
          <fpage>599</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-10-599"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/1471-2458-10-599</pub-id>
          <pub-id pub-id-type="medline">20937148</pub-id>
          <pub-id pub-id-type="pii">1471-2458-10-599</pub-id>
          <pub-id pub-id-type="pmcid">PMC2964624</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref74">
        <label>74</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kesavadev</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Saboo</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Shankar</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Krishnan</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Jothydev</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Telemedicine for diabetes care: an Indian perspective - feasibility and efficacy</article-title>
          <source>Indian J Endocrinol Metab</source>
          <year>2015</year>
          <volume>19</volume>
          <issue>6</issue>
          <fpage>764</fpage>
          <lpage>9</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.ijem.in/article.asp?issn=2230-8210;year=2015;volume=19;issue=6;spage=764;epage=769;aulast=Kesavadev"/>
          </comment>
          <pub-id pub-id-type="doi">10.4103/2230-8210.167560</pub-id>
          <pub-id pub-id-type="medline">26693425</pub-id>
          <pub-id pub-id-type="pii">IJEM-19-764</pub-id>
          <pub-id pub-id-type="pmcid">PMC4673803</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref75">
        <label>75</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ma</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Zhao</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Zhao</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Lu</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Jiang</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Cao</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Xu</surname>
              <given-names>Y</given-names>
            </name>
          </person-group>
          <article-title>Telemedicine application in patients with chronic disease: a systematic review and meta-analysis</article-title>
          <source>BMC Med Inform Decis Mak</source>
          <year>2022</year>
          <month>04</month>
          <day>19</day>
          <volume>22</volume>
          <issue>1</issue>
          <fpage>105</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcmedinformdecismak.biomedcentral.com/articles/10.1186/s12911-022-01845-2"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12911-022-01845-2</pub-id>
          <pub-id pub-id-type="medline">35440082</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12911-022-01845-2</pub-id>
          <pub-id pub-id-type="pmcid">PMC9017076</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref76">
        <label>76</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Timpel</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Oswald</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Schwarz</surname>
              <given-names>PE</given-names>
            </name>
            <name name-style="western">
              <surname>Harst</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Mapping the evidence on the effectiveness of telemedicine interventions in diabetes, dyslipidemia, and hypertension: an umbrella review of systematic reviews and meta-analyses</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>03</month>
          <day>18</day>
          <volume>22</volume>
          <issue>3</issue>
          <fpage>e16791</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/3/e16791/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/16791</pub-id>
          <pub-id pub-id-type="medline">32186516</pub-id>
          <pub-id pub-id-type="pii">v22i3e16791</pub-id>
          <pub-id pub-id-type="pmcid">PMC7113804</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref77">
        <label>77</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sherwani</surname>
              <given-names>SI</given-names>
            </name>
            <name name-style="western">
              <surname>Khan</surname>
              <given-names>HA</given-names>
            </name>
            <name name-style="western">
              <surname>Ekhzaimy</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Masood</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Sakharkar</surname>
              <given-names>MK</given-names>
            </name>
          </person-group>
          <article-title>Significance of HbA1c test in diagnosis and prognosis of diabetic patients</article-title>
          <source>Biomark Insights</source>
          <year>2016</year>
          <month>07</month>
          <day>03</day>
          <volume>11</volume>
          <pub-id pub-id-type="doi">10.4137/bmi.s38440</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref78">
        <label>78</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kusuma</surname>
              <given-names>CF</given-names>
            </name>
            <name name-style="western">
              <surname>Aristawidya</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Susanti</surname>
              <given-names>CP</given-names>
            </name>
            <name name-style="western">
              <surname>Kautsar</surname>
              <given-names>AP</given-names>
            </name>
          </person-group>
          <article-title>A review of the effectiveness of telemedicine in glycemic control in diabetes mellitus patients</article-title>
          <source>Medicine (Baltimore)</source>
          <year>2022</year>
          <month>12</month>
          <day>02</day>
          <volume>101</volume>
          <issue>48</issue>
          <fpage>e32028</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/36482628"/>
          </comment>
          <pub-id pub-id-type="doi">10.1097/MD.0000000000032028</pub-id>
          <pub-id pub-id-type="medline">36482628</pub-id>
          <pub-id pub-id-type="pii">00005792-202212020-00113</pub-id>
          <pub-id pub-id-type="pmcid">PMC9726301</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref79">
        <label>79</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Bodenheimer</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Wagner</surname>
              <given-names>EH</given-names>
            </name>
            <name name-style="western">
              <surname>Grumbach</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Improving primary care for patients with chronic illness</article-title>
          <source>JAMA</source>
          <year>2002</year>
          <month>10</month>
          <day>09</day>
          <volume>288</volume>
          <issue>14</issue>
          <fpage>1775</fpage>
          <lpage>9</lpage>
          <pub-id pub-id-type="doi">10.1001/jama.288.14.1775</pub-id>
          <pub-id pub-id-type="medline">12365965</pub-id>
          <pub-id pub-id-type="pii">jip21004</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref80">
        <label>80</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nourine</surname>
              <given-names>I</given-names>
            </name>
          </person-group>
          <article-title>Influence des comorbidités sur la prise en charge du diabète de type 2 de la personne âgée</article-title>
          <source>Universite de Lorraine</source>
          <year>2016</year>
          <month>3</month>
          <day>8</day>
          <access-date>2024-01-19</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://hal.univ-lorraine.fr/hal-01932239/document">https://hal.univ-lorraine.fr/hal-01932239/document</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref81">
        <label>81</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <collab>UK Hypoglycaemia Study Group</collab>
          </person-group>
          <article-title>Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration</article-title>
          <source>Diabetologia</source>
          <year>2007</year>
          <month>06</month>
          <day>6</day>
          <volume>50</volume>
          <issue>6</issue>
          <fpage>1140</fpage>
          <lpage>7</lpage>
          <pub-id pub-id-type="doi">10.1007/s00125-007-0599-y</pub-id>
          <pub-id pub-id-type="medline">17415551</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref82">
        <label>82</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Budnitz</surname>
              <given-names>DS</given-names>
            </name>
            <name name-style="western">
              <surname>Lovegrove</surname>
              <given-names>MC</given-names>
            </name>
            <name name-style="western">
              <surname>Shehab</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Richards</surname>
              <given-names>CL</given-names>
            </name>
          </person-group>
          <article-title>Emergency hospitalizations for adverse drug events in older Americans</article-title>
          <source>N Engl J Med</source>
          <year>2011</year>
          <month>11</month>
          <day>24</day>
          <volume>365</volume>
          <issue>21</issue>
          <fpage>2002</fpage>
          <lpage>12</lpage>
          <pub-id pub-id-type="doi">10.1056/nejmsa1103053</pub-id>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
