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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="review-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMI</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Med Inform</journal-id>
      <journal-title>JMIR Medical Informatics</journal-title>
      <issn pub-type="epub">2291-9694</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v5i4e41</article-id>
    <article-id pub-id-type="pmid">29066424</article-id>
    <article-id pub-id-type="doi">10.2196/medinform.6603</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Review</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Review</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>Adopting Telemedicine for the Self-Management of Hypertension: Systematic Review</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Eysenbach</surname>
          <given-names>Gunther</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Cianflone</surname>
          <given-names>Domenico</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Subasinghe</surname>
          <given-names>Asvini</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1" corresp="yes" equal-contrib="yes">
      <name name-style="western">
        <surname>Mileski</surname>
        <given-names>Michael</given-names>
      </name>
      <degrees>MPH, MHA, MSHEd, DC</degrees>
      <xref rid="aff1" ref-type="aff">1</xref>
      <address>
        <institution>School of Health Administration</institution>
        <institution>Texas State University</institution>
        <addr-line>601 University Drive</addr-line>
        <addr-line>San Marcos, TX, 78666</addr-line>
        <country>United States</country>
        <phone>1 832 752 4419</phone>
        <fax>1 512 245 8712</fax>
        <email>mileski@txstate.edu</email>
      </address>  
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-1503-6869</ext-link></contrib>
      <contrib contrib-type="author" id="contrib2" equal-contrib="yes">
        <name name-style="western">
          <surname>Kruse</surname>
          <given-names>Clemens Scott</given-names>
        </name>
        <degrees>MBA, MSIT, MHA, PhD</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-7636-1086</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib3" equal-contrib="yes">
        <name name-style="western">
          <surname>Catalani</surname>
          <given-names>Justin</given-names>
        </name>
        <degrees>BHA</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-3144-1373</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib4" equal-contrib="yes">
        <name name-style="western">
          <surname>Haderer</surname>
          <given-names>Tara</given-names>
        </name>
        <degrees>BHA</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-0351-5918</ext-link>
      </contrib>
    </contrib-group>
    <aff id="aff1">
    <sup>1</sup>
    <institution>School of Health Administration</institution>
    <institution>Texas State University</institution>  
    <addr-line>San Marcos, TX</addr-line>
    <country>United States</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Michael Mileski 
      <email>mileski@txstate.edu</email></corresp>
    </author-notes>
    <pub-date pub-type="collection"><season>Oct-Dec</season><year>2017</year></pub-date>
    <pub-date pub-type="epub">
      <day>24</day>
      <month>10</month>
      <year>2017</year>
    </pub-date>
    <volume>5</volume>
    <issue>4</issue>
    <elocation-id>e41</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>1</day>
        <month>9</month>
        <year>2016</year>
      </date>
      <date date-type="rev-request">
        <day>25</day>
        <month>10</month>
        <year>2016</year>
      </date>
      <date date-type="rev-recd">
        <day>18</day>
        <month>11</month>
        <year>2016</year>
      </date>
      <date date-type="accepted">
        <day>1</day>
        <month>7</month>
        <year>2017</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Michael Mileski, Clemens Scott Kruse, Justin Catalani, Tara Haderer. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 24.10.2017.</copyright-statement>
    <copyright-year>2017</copyright-year>
    <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Informatics, is properly cited. The complete bibliographic information, a link to the original publication on http://medinform.jmir.org/, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="http://medinform.jmir.org/2017/4/e41/" xlink:type="simple"/>
    <abstract>
      <sec sec-type="background">
        <title>Background</title>
        <p>Hypertension is a chronic condition that affects adults of all ages. In the United States, 1 in 3 adults has hypertension, and about half of the hypertensive population is adequately controlled. This costs the nation US $46 billion each year in health care services and medications required for treatment and missed workdays. Finding easier ways of managing this condition is key to successful treatment.</p>
      </sec>
      <sec sec-type="objective">
        <title>Objective</title>
        <p>A solution to reduce visits to physicians for chronic conditions is to utilize telemedicine. Research is limited on the effects of utilizing telemedicine in health care facilities. There are potential benefits for implementing telemedicine programs with patients dealing with chronic conditions. The purpose of this review was to weigh the facilitators against the barriers for implementing telemedicine.</p>
      </sec>
      <sec sec-type="methods">
        <title>Methods</title>
        <p>Searches were methodically conducted in the Cumulative Index to Nursing and Allied Health Literature Complete (CINAHL Complete) via Elton B Stephens Company (EBSCO) and PubMed (which queries MEDLINE) to collect information about self-management of hypertension through the use of telemedicine.</p>
      </sec>
      <sec sec-type="results">
        <title>Results</title>
        <p>Results identify facilitators and barriers corresponding to the implementation of self-management of hypertension using telemedicine. The most common facilitators include increased access, increase in health and quality, patient knowledge and involvement, technology growth with remote monitoring, cost-effectiveness, and increased convenience/ease. The most prevalent barriers include lack of evidence, self-management difficult to maintain, no long-term results/more areas to address, and long-term added workload commitment.</p>
      </sec>
      <sec sec-type="conclusions">
        <title>Conclusions</title>
        <p>This review guides health care professionals in incorporating new practices and identifying the best methods to introduce telemedicine into their practices. Understanding the facilitators and barriers to implementation is important, as is understanding how these factors will impact a successful implementation of telemedicine in the area of self-management of hypertension.</p>
      </sec>
    </abstract>
    <kwd-group>
      <kwd>hypertension</kwd>
      <kwd>telemedicine</kwd>
      <kwd>eHealth</kwd>
      <kwd>mHealth</kwd>
      <kwd>disease management</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Incentives</title>
        <p>The Patient Protection and Affordable Care Act of 2010 (PPACA) has put a burden on health care facilities, forcing them to cut costs and focus on quality. We must find effective methods to keep patients with chronic diseases such as hypertension and diabetes from having to come to the facility directly, by allowing them the choice of being monitored from home. This is easily and effectively done through telemedicine, such as telephone-based medicine, electronic medicine, or videoconferencing [<xref ref-type="bibr" rid="ref1">1</xref>]. Telemedicine has incentives for health care facilities and the patients who would participate. These incentives include increased access to rural areas, increased involvement of nurses, decreased involvement of doctors in menial tasks, potential cost-effectiveness, interactive behavior change, high patient satisfaction, and positive long-term health outcomes [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref5">5</xref>]. Although there are clear advantages and evidence showing that telemedicine improves outcomes of hypertension and other chronic illness not only in the short term but also in the long term, studies show that health care facilities and medical staff are skeptical regarding the adoption of telemedicine models because of the shift of responsibility to the provider to check up on the patient [<xref ref-type="bibr" rid="ref6">6</xref>].</p>
        <p>Incentives for cost cutting and improved outcomes exist through PPACA and Medicare reimbursement policies. By increasing the quality and patient satisfaction, higher reimbursement can be realized through federally funded programs. Telemedicine can be rapidly implemented and can easily negate some of the financial burdens in facilities throughout the United States by higher patient volumes and by more efficient use of patient-physician care time [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
      </sec>
      <sec>
        <title>Identification and Definition of Key Terms</title>
        <p>According to the World Health Organization, telemedicine is “the delivery of health care services, where distance is a critical factor, by all health care professionals using information and communication technologies for the exchange of valid information for diagnosis, treatment and prevention of diseases and injuries, research and evaluation, and for the continuing education of health care providers, all in the interests of advancing the health of individuals and their communities” [<xref ref-type="bibr" rid="ref7">7</xref>]. The use of telemedicine has expanded vastly to include a “variety of applications and services using two-way video, email, smartphones, wireless tools and other forms of telecommunications technology” [<xref ref-type="bibr" rid="ref2">2</xref>]. Telemedicine has the potential to impact the health care industry in profound ways with the constant creation and innovation of technology. Currently, the health care system relies on face-to-face communication to deliver care. Telemedicine offers a method to be utilized in conjunction with face-to-face communication with providers. It is not a separate specialty in the medical field because telemedicine is typically integrated in health care institutions within information technology or the delivery of care [<xref ref-type="bibr" rid="ref2">2</xref>]. There is no distinction between the terms “telemedicine” and “telehealth,” and they are considered interchangeable to encompass a variety of remote health care options [<xref ref-type="bibr" rid="ref7">7</xref>]. Patient consultations via videoconferencing, transmission of still images, electronic health (eHealth) including patient portals, remote monitoring of vital signs, continuing medical education, consumer-focused wireless applications, and nursing call centers, among other applications, are all considered part of telemedicine and telehealth [<xref ref-type="bibr" rid="ref7">7</xref>].</p>
      </sec>
      <sec>
        <title>Hypertension Defined</title>
        <p>Hypertension is defined as having abnormally high blood pressure [<xref ref-type="bibr" rid="ref8">8</xref>]. Known as the “silent killer,” hypertension is listed as one of the most important causes for premature death; it affects 1 billion people worldwide, with two-thirds found in developing countries [<xref ref-type="bibr" rid="ref9">9</xref>]. These numbers are growing at an alarming rate, with an estimated 1.56 billion adults to be afflicted with hypertension by 2025 [<xref ref-type="bibr" rid="ref9">9</xref>]. Hypertension is a chronic condition that occurs when blood is pumped through the arteries with excessive force [<xref ref-type="bibr" rid="ref1">1</xref>]. Hypertension can lead to many health risks, including heart attacks, strokes, kidney failure, or other life-threatening health problems [<xref ref-type="bibr" rid="ref1">1</xref>]. Causes of hypertension can include kidney fluid and salt balances, blood vessel structure, genetic causes, and environmental causes such as unhealthy lifestyles, obesity, and the use of certain medications [<xref ref-type="bibr" rid="ref8">8</xref>]. In the United States, 1 of every 3 adults has hypertension and only about half of the population with hypertension has the condition under control [<xref ref-type="bibr" rid="ref9">9</xref>]. This costs the nation US $46 billion each year in health care services and medications required for treatment and missed workdays [<xref ref-type="bibr" rid="ref9">9</xref>].</p>
      </sec>
      <sec>
        <title>Physician Dependence and Self-Management</title>
        <p>Patients are highly dependent on their physicians for information on their health. Self-management refers to taking responsibility for one’s own behavior and well-being. Implementing self-management in the health care setting is the start to educating patients of their current state of health and conditions affecting them. Educating not only improves the individual’s knowledge of the condition but also allows for early detection of health problems and enables the individual to correctly self-titrate medications and allows for timely interventions [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref8">8</xref>].</p>
      </sec>
      <sec>
        <title>Telemedicine Adoption Among Health Facilities</title>
        <p>Facilities that have adopted models of telemedicine have shown better patient outcomes and satisfaction, higher patient volumes, and increased facility space to be used for other purposes. Although recent studies have not shown a direct short-term relationship to cost savings, they recognize that in the long-term, cost-effectiveness will be realized [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>]. With the obesity rate in America at an all-time high, along with hypertension diagnoses on the rise, it is important to recognize the benefits that telemedicine offers to consumers. Some of these are sustainable intervention, long-term blood pressure control, improved patient knowledge and accountability, facilitated communication between the patient and the provider, and long-term cost-effectiveness [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]. The benefits of telemedicine are yet to be fully realized through research, and it could easily become a regulation to implement it as a tool, such as electronic health records or the International Classification of Diseases, Tenth Edition (ICD-10). It is in the best interests of health facilities to implement this technologically advanced medical care technique into their operations, allowing for a competitive advantage.</p>
      </sec>
      <sec>
        <title>Telemedicine Impact</title>
        <p>Although telemedicine offers numerous benefits, the benefits are not fully recognized at the beginning of implementation. With no governmental incentives existing in place for telemedicine, facilities are skeptical to take the leap into this new care technique. This review highlights the facilitators and barriers to implementing telemedicine techniques into health care facilities to identify the benefits that can be realized if adopted [<xref ref-type="bibr" rid="ref2">2</xref>-<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>].</p>
      </sec>
      <sec>
        <title>Rationale</title>
        <p>The findings of this review will be useful to health administrators, physicians, nurses, and other stakeholders in facilities that are weighing the potential benefits and barriers of adopting a telemedicine policy into their organization. This review is also useful to patients. With the ability of technology to inform the public, patient awareness on the management of their own health has made them a major stakeholder in health care. By extending these findings to the public, increased awareness of the positive outcomes to the adoption of telemedicine might be the push to implementation that the health care facilities need.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Data Collection Process</title>
        <p>Information for this review was collected through the use of two databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL) Complete via Elton B Stephens Company (EBSCOhost) and PubMed (which queries MEDLINE). The search focused on self-management of hypertension through the use of telemedicine. The members of the research team reviewed the papers identified during the search and summarized data relative to this review. During successive independent reviews, members compared and discussed the papers and reasons for their inclusion in the study. Papers were included based on their discussion of facilitators and barriers to the self-management of hypertension via telemedicine. The members of the research team had full agreement on all papers included in this systematic review.</p>
      </sec>
      <sec>
        <title>Sample</title>
        <p>Research databases were queried from PubMed and CINAHL using search terms of (“telehealth” OR “Telemedicine” OR “eHealth” OR “mHealth” OR “information technology”) AND (“self-management” OR “self management”) AND (“hypertension” OR “high blood pressure” OR “elevated blood pressure”). Several exclusion criteria were also specified: duplicates were excluded; only academic journals were included; papers were in English only; human-based studies were only included; study protocols and designs were eliminated; and nongermane trials were excluded. Searches were limited to date of publication from 2010 to 2016 (n=14). This process is illustrated in <xref ref-type="fig" rid="figure1">Figure 1</xref>.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Preferred Reporting Items for Systematic Reviews flow diagram.</p>
          </caption>
          <graphic xlink:href="medinform_v5i4e41_fig1.jpg" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
    
      <table-wrap position="float" id="table1">
        <label>Table 1</label>
        <caption>
          <p>Facilitators and barriers associated with the implementation of telehealth in the self-management of hypertension.</p>
        </caption>
        <table width="725" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="135"/>
          <col width="300"/>
          <col width="300"/>
          <thead>
            <tr valign="top">
              <td>Authors</td>
              <td>Facilitators</td>
              <td>Barriers</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td>McKoy et al [<xref ref-type="bibr" rid="ref13">13</xref>]</td>
              <td>Rapidly evolving technology</td>
              <td>Self-management requires much support</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Decreased costs for providing care</td>
              <td>Limited oversight, regulation, and guidelines</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Mobile phones can become electrocardiographs (EKG) or other diagnostic machines</td>
              <td>Blurring of professional role of practitioners</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Increased access to care that patients otherwise may not receive</td>
              <td>Potential for increased liability for practitioners</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Large application to medically underserved areas</td>
              <td>Need for identification for ways to mitigate risk</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Ease in scheduling, communication, monitoring, and management for patients and practitioners</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Kumar et al [<xref ref-type="bibr" rid="ref14">14</xref>]</td>
              <td>Apps attached to practitioners have increased oversight of patients and ease of facilitation of care</td>
              <td>Many available apps for mobile phones do not have a practitioner involved with them</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td><break/></td>
              <td>Apps available are not documented as valid ways to measure blood pressure</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td><break/></td>
              <td>No oversight to app production or effectiveness</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td><break/></td>
              <td>Lack of Food and Drug Administration approval</td>
            </tr>
            <tr valign="top">
              <td>Kaambwa et al [<xref ref-type="bibr" rid="ref3">3</xref>]</td>
              <td>Cost-effective in the long run</td>
              <td>Differences in results compared with other studies</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Adjusted life years gained</td>
              <td>Varying results between men and women</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Markov model</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Reduced blood pressure compared with usual care</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Maciejewski et al [<xref ref-type="bibr" rid="ref12">12</xref>]</td>
              <td>Sustainable intervention</td>
              <td>No economic gains</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Long-term blood pressure control</td>
              <td>Not many other studies to exhibit consistency</td>
            </tr>
            <tr valign="top">
              <td>Wakefield et al [<xref ref-type="bibr" rid="ref15">15</xref>]</td>
              <td>Home-based</td>
              <td>No significant difference between intervention and control group</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>More timely changes</td>
              <td>Information technology unlikely to lead to improved outcomes alone</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Targets remote treatment outcomes</td>
              <td>Need for responsive clinical processes</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Effectiveness in the short term</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Shaw et al [<xref ref-type="bibr" rid="ref16">16</xref>]</td>
              <td>Improved patient outcome</td>
              <td>Unclear long-term commitment</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Positive organizational culture</td>
              <td>Added workload</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Evidence-based and nurse administered</td>
              <td>Skeptical staff on positive outcomes</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Information technology infrastructure and support</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Utilization of existing equipment and space</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Fitzner and Moss [<xref ref-type="bibr" rid="ref4">4</xref>]</td>
              <td>Increased access</td>
              <td>Literacy level</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Interactive behavior change technology</td>
              <td>Comfort level with technology</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Chronic care model</td>
              <td>Security of personal health data</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Technological tools lead to improved patient health</td>
              <td>Accuracy of information</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>High access to telecommunication</td>
              <td>Medicare’s efforts to extend reimbursement to self-management training</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Ease and immediacy of communication</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Convenience of home</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Portable</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Rapid growth of use in mobile phones</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Effective, efficient, and affordable ways to reach and support minorities</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Melnyk et al [<xref ref-type="bibr" rid="ref10">10</xref>]</td>
              <td>Patient Care Alignment Teams; stresses non-face-to-face interactions</td>
              <td>Patients adherence to the guidelines/rules</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Facilitates individualized personal interaction</td>
              <td>Self-management components to consider</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Remedies face-to-face intervention problems</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Piette, Marinec et al [<xref ref-type="bibr" rid="ref5">5</xref>]</td>
              <td>Increased access to health information between visits</td>
              <td>Interactive voice response call completion rate declined</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Information for users</td>
              <td>Technical challenges</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Delivered from long distances</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Jackson et al [<xref ref-type="bibr" rid="ref17">17</xref>]</td>
              <td>Medical and behavioral aspects addressed</td>
              <td><break/></td>
            </tr>
            <tr valign="top">
              <td>Piette, Datwani et al [<xref ref-type="bibr" rid="ref18">18</xref>]</td>
              <td>Access</td>
              <td>Labor intensive and rarely available in low- and middle-income countries</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Cloud computing can make mobile health (mHealth) services more accessible</td>
              <td>Lacks the resources to launch and maintain an mHealth service</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td><break/></td>
              <td>Relatively little collaborative work with patients’ clinical teams</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td><break/></td>
              <td>Effort to educate providers</td>
            </tr>
            <tr valign="top">
              <td>Wang et al [<xref ref-type="bibr" rid="ref11">11</xref>]</td>
              <td>Hypertension is a common reason for men to go to the doctor</td>
              <td>Substantial time costs accumulated for nurses to prepare</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Different telephone interventions added with usual care</td>
              <td>No long-term difference in results compared with usual care</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Costs may not significantly differ from that of usual care</td>
              <td>Hypertension Intervention Nurse Telemedicine Study (HINTS) intervention was costly and time-consuming to deliver</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td><break/></td>
              <td>Unknown whether intervention generates other patient-centered outcomes or efficiencies in other aspects of medical care</td>
            </tr>
            <tr valign="top">
              <td>Jones et al [<xref ref-type="bibr" rid="ref6">6</xref>]</td>
              <td>Participants valued additional information</td>
              <td>Self-management hard to be maintained by participants</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Home blood pressure readings more natural</td>
              <td>Borderline readings</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Greater control and more involvement</td>
              <td>Self-titration</td>
            </tr>
            <tr valign="top">
              <td><break/></td>
              <td>Improvement of knowledge for the patient</td>
              <td>Needs significant input from general practitioner</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </sec>


<sec>
        <title>Data Analysis</title>
        <p>Narrative summaries related to factors that influenced the adoption of telemedicine for the self-management of hypertension were extracted from each paper and included in <xref ref-type="table" rid="table1">Table 1</xref>. These, in turn, were grouped into larger recurring themes: either key determinants or impediments to success. The themes chosen were by consensus of the authors. Those chosen were agreed upon to be ones that provided overarching summary to the facilitators and barriers extracted. These themes were then divided into two affinity matrix tables for facilitators and barriers. Each table documents the themes, their citation occurrence, their frequency sum, and their frequency percentage.</p>
</sec>
</sec>
  <sec sec-type="results">
      <title>Results</title>
      <p>The findings were summarized into the facilitators and barriers table after the members of the research team chose papers to construct the systematic literature review. All identical papers were analyzed and unified before the table was generated. The members of the research team reevaluated the papers and determined facilitators and barriers in the self-management of hypertension via telemedicine. Results are summarized in <xref ref-type="table" rid="table1">Table 1</xref>. Papers are listed in the order of publication, with the most recent papers at the top.</p>
      <p>During the course of the period chosen (2010-2016) for this systematic review, 112 authors published 14 works that specifically studied, analyzed, and discussed factors relating to the self-management of hypertension via telemedicine. Most of these works highlighted both facilitators and barriers, and only one highlighted only facilitators. Papers originated from multiple countries, and a total of 48 facilitators (55%) and 40 barriers (45%) were observed.</p>
</sec> 

<sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Facilitators</title>
        <p>About 17% more facilitators to implementation were noted than barriers (48:40). The authors of this review compared and grouped the facilitators and barriers into common themes. A total of 24 themes were noted between the two categories. A total of 13 facilitator theme categories and 11 barrier categories were identified. <xref ref-type="table" rid="table2">Table 2</xref> illustrates and rank orders the themes from the facilitators based on their frequency of occurrence in the literature.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Facilitating themes associated with the implementation of telemedicine in the self-management of hypertension.</p>
          </caption>
          <table width="460" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="205"/>
            <col width="200"/>
            <col width="60"/>
            <thead>
              <tr valign="top">
                <td>Facilitators</td>
                <td>Occurrences</td>
                <td>Frequency (N=48) <break/>n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Increased access</td>
                <td>
[<xref ref-type="bibr" rid="ref4">4</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref5">5</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref13">13</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref18">18</xref>]
</td>
                <td>7 (15)</td>
              </tr>
              <tr valign="top">
                <td>Increase in health and quality</td>
                <td>
[<xref ref-type="bibr" rid="ref3">3</xref>], 
[<xref ref-type="bibr" rid="ref4">4</xref>],

[<xref ref-type="bibr" rid="ref12">12</xref>], 
[<xref ref-type="bibr" rid="ref14">14</xref>], 


[<xref ref-type="bibr" rid="ref15">15</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref16">16</xref>] 

</td>
                <td>7 (15)</td>
              </tr>
              <tr valign="top">
                <td>Patient knowledge and involvement</td>
                <td>
[<xref ref-type="bibr" rid="ref4">4</xref>], 
[<xref ref-type="bibr" rid="ref5">5</xref>], 
[<xref ref-type="bibr" rid="ref6">6</xref>]<sup>a</sup>,
[<xref ref-type="bibr" rid="ref17">17</xref>] 
</td>
                <td>6 (13)</td>
              </tr>
              <tr valign="top">
                <td>Technology growth with remote monitoring</td>
                <td>
[<xref ref-type="bibr" rid="ref4">4</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref13">13</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref16">16</xref>], 

[<xref ref-type="bibr" rid="ref18">18</xref>]
</td>
                <td>6 (13)</td>
              </tr>
              <tr valign="top">
                <td>Cost-effectiveness</td>
                <td>[<xref ref-type="bibr" rid="ref3">3</xref>]<sup>a</sup>, [<xref ref-type="bibr" rid="ref4">4</xref>], [<xref ref-type="bibr" rid="ref11">11</xref>], [<xref ref-type="bibr" rid="ref13">13</xref>]</td>
                <td>5 (10)</td>
              </tr>
              <tr valign="top">
                <td>Increased convenience and ease</td>
                <td>[<xref ref-type="bibr" rid="ref4">4</xref>]<sup>a</sup>, [<xref ref-type="bibr" rid="ref13">13</xref>], [<xref ref-type="bibr" rid="ref15">15</xref>]</td>
                <td>4 (8)</td>
              </tr>
              <tr valign="top">
                <td>Facilitates communication</td>
                <td>[<xref ref-type="bibr" rid="ref10">10</xref>]<sup>a</sup>, [<xref ref-type="bibr" rid="ref16">16</xref>]</td>
                <td>3 (6)</td>
              </tr>
              <tr valign="top">
                <td>Natural readings</td>
                <td>[<xref ref-type="bibr" rid="ref3">3</xref>], [<xref ref-type="bibr" rid="ref6">6</xref>], [<xref ref-type="bibr" rid="ref12">12</xref>]</td>
                <td>3 (6)</td>
              </tr>
              <tr valign="top">
                <td>Personalized care</td>
                <td>[<xref ref-type="bibr" rid="ref10">10</xref>], [<xref ref-type="bibr" rid="ref11">11</xref>]<sup>a</sup></td>
                <td>3 (6)</td>
              </tr>
              <tr valign="top">
                <td>Utilizing nurses</td>
                <td>[<xref ref-type="bibr" rid="ref16">16</xref>]</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td>Portable</td>
                <td>[<xref ref-type="bibr" rid="ref4">4</xref>]</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td>Timely</td>
                <td>[<xref ref-type="bibr" rid="ref15">15</xref>]</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td>Utilizing space</td>
                <td>[<xref ref-type="bibr" rid="ref16">16</xref>]</td>
                <td>1 (2)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>Denotes multiple occurrences in the same paper.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>Facilitators mentioned most often in the literature were increased access [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref18">18</xref>] (multiple occurrences per article: 6,12,14) and increase in health and quality [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>-<xref ref-type="bibr" rid="ref16">16</xref>] (multiple occurrences per article: 10). These themes were identified 7 times each, out of 41 total occurrences (17% each). Regarding increased access, authors have noted facilitators where patients found themselves with access to care that they might otherwise not receive [<xref ref-type="bibr" rid="ref13">13</xref>] and that technology could easily be adapted to use for medically underserved populations [<xref ref-type="bibr" rid="ref13">13</xref>]. Furthermore, there was an overall increased access to care and telecommunication by the use of telemedicine [<xref ref-type="bibr" rid="ref4">4</xref>]. The use of the technology also allowed for care to be delivered over long distances, which increased not only access to care but also access to health information [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref18">18</xref>].</p>
        <p>Increases in health and quality facilitators were noted in areas that allowed practitioners to have increased oversight of their patients and an easing of the facilitation of care [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>]. The telemedicine intervention was also noted to be sustainable [<xref ref-type="bibr" rid="ref12">12</xref>] and could target treatment outcomes remotely [<xref ref-type="bibr" rid="ref15">15</xref>], which allowed for increased effectiveness in treatment, a gain of adjusted life years, and improved patient outcomes [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>].</p>
        <p>The next two most identified themes were patient knowledge and involvement [<xref ref-type="bibr" rid="ref4">4</xref>-<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref17">17</xref>] (multiple occurrences per article: 18) and technology growth with remote monitoring [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref18">18</xref>] (multiple occurrences per article: 6,12). These themes were identified 6 times each, out of 41 total occurrences (15% each). Patient knowledge and involvement themes mostly focused on how patients could benefit from the use of this technology. Behavior changes [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref17">17</xref>] and additional information and greater control and involvement for patients [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>] were noted. Increased knowledge for the patients empowered them to make better decisions and have more control of their own care [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. There was also a “value-added” component to the use of telemedicine, as there was additional information available regarding the diagnosis to patients, which otherwise might not have been readily available [<xref ref-type="bibr" rid="ref6">6</xref>].</p>
        <p>Technology growth was also an important theme identified; the more this technology is used, the greater the applications that will be identified [<xref ref-type="bibr" rid="ref13">13</xref>]. Everyday devices such as mobile phones can be utilized as an electrocardiograph (EKG) or other diagnostic machines [<xref ref-type="bibr" rid="ref13">13</xref>]. Increased use also will lead to increased options in information technology infrastructure and support [<xref ref-type="bibr" rid="ref16">16</xref>] and increased tools to use to promote health in patients [<xref ref-type="bibr" rid="ref4">4</xref>]. This technology could also drive advances in mobile phones and cloud computing [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref18">18</xref>].</p>
        <p>The cost-effective nature of the use of telemedicine in the treatment of hypertension was identified 5 times [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref13">13</xref>] (multiple occurrences per article: 8) (12%). Telemedicine has been shown to be effective, efficient, and affordable in reaching its target population [<xref ref-type="bibr" rid="ref4">4</xref>]. Furthermore, it is shown to have decreased costs overall for providing care [<xref ref-type="bibr" rid="ref13">13</xref>], despite the cost of the per-unit provision of care being the same [<xref ref-type="bibr" rid="ref11">11</xref>]. The long-term use of this as an intervention is where most cost savings are seen [<xref ref-type="bibr" rid="ref3">3</xref>]. Studies in the area of cost-effectiveness have been weak overall; however, it is believed that there has been a gross underestimation in this area, as the cost of technology has decreased over time [<xref ref-type="bibr" rid="ref13">13</xref>]. Cost of self-management was shown to be higher overall in some cases, but as it was associated with an increase in quality of life for patients with a decrease in cardiovascular events, a net savings was noted [<xref ref-type="bibr" rid="ref3">3</xref>]. These results are further verified in reduced overall costs for the care of patients with the use of telemedicine technologies, despite their increased front-end cost overall [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref11">11</xref>].</p>
        <p>Increased convenience/ease of the use of telemedicine in the treatment of hypertension was identified 4 times [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref15">15</xref>] (multiple occurrences per article: 12) (10%). Patients were able to realize an ease in their ability to receive care from the convenience of their own homes [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. This translated into not only easier access for patients and providers [<xref ref-type="bibr" rid="ref18">18</xref>] but also more immediate communication between patients and providers [<xref ref-type="bibr" rid="ref4">4</xref>]. Providers found significant benefits in the areas of scheduling ease, communications with patients, disease monitoring, and disease management [<xref ref-type="bibr" rid="ref13">13</xref>].</p>
        <p>Three theme areas were next tied with each other in incidence. Facilitates communication [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref16">16</xref>] (multiple occurrences per article: 13), natural readings [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref12">12</xref>], and personalized care [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>] (multiple occurrences per article: 17) were all identified 3 times (7% each). An advantage to the use of telemedicine identified was that it alleviates issues regarding interventions in the face-to-face method [<xref ref-type="bibr" rid="ref10">10</xref>]. Furthermore, communication is facilitated, as the use of telemedicine is able to create a positive organizational culture for patients and practitioners alike [<xref ref-type="bibr" rid="ref16">16</xref>]. Also of note is that blood pressure readings in the home environment are more natural [<xref ref-type="bibr" rid="ref6">6</xref>] and are not plagued by the stress of the medical office or “white coat syndrome.” These more natural readings, which are facilitated because of the use of telemedicine, show patients to have decreased blood pressure readings versus normal in office care [<xref ref-type="bibr" rid="ref13">13</xref>], which in turn assists in long-term blood pressure control [<xref ref-type="bibr" rid="ref12">12</xref>]. This ties in with personalized care, as telemedicine facilitates individualized personalized interactions [<xref ref-type="bibr" rid="ref10">10</xref>]. It also fosters care for those who might otherwise not go to the physician for treatment [<xref ref-type="bibr" rid="ref11">11</xref>] and allows for different interventions outside the normal ones, which would come with usual care for hypertension [<xref ref-type="bibr" rid="ref11">11</xref>].</p>
        <p>The last four facilitators were each mentioned once in the identified papers. Utilizing nurses [<xref ref-type="bibr" rid="ref16">16</xref>], portable [<xref ref-type="bibr" rid="ref4">4</xref>], timely [<xref ref-type="bibr" rid="ref15">15</xref>], and utilizing space [<xref ref-type="bibr" rid="ref16">16</xref>] were all mentioned one time in the thematic review (2% each). Nurses were able to provide more timely care and intervention than would normally happen in the office environment [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>]. The technology that is required is portable and can be carried with the patients anywhere they go [<xref ref-type="bibr" rid="ref4">4</xref>], which allows for increased ability to give timely care [<xref ref-type="bibr" rid="ref15">15</xref>]. An existing practice can additionally expand its reach and patient base, as the implementation of technology will not take more space resources, and it can utilize existing equipment in most cases [<xref ref-type="bibr" rid="ref16">16</xref>]. This allows for an increased patient load and an increase in the amount of care given in a timely fashion.</p>
      </sec>
      <sec>
        <title>Barriers</title>
        <p>The barrier mentioned most often in the literature was lack of evidence [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>] (multiple occurrences per article: 7,8), which was identified 9 times of 40 total incidences (23%). Lack of evidence was an area that showed many possible concerns. Telemedicine lacks oversight in the area of application production or effectiveness [<xref ref-type="bibr" rid="ref14">14</xref>]. Additionally, it lacks Food and Drug Administration approval [<xref ref-type="bibr" rid="ref14">14</xref>]. There is evidence to show that there are differences in effectiveness between men and women [<xref ref-type="bibr" rid="ref3">3</xref>] and that there are other inconsistencies between the programs (and the research surrounding them) [<xref ref-type="bibr" rid="ref12">12</xref>]. Due to these inconsistencies, staff seem to be skeptical about the use of technology in this fashion [<xref ref-type="bibr" rid="ref16">16</xref>], as the accuracy of the information provided [<xref ref-type="bibr" rid="ref4">4</xref>] and the validity of the results are in question [<xref ref-type="bibr" rid="ref14">14</xref>]. Furthermore, inconsistencies also question the outcomes generated by the apps and the efficiency of the use of telemedicine to monitor hypertension [<xref ref-type="bibr" rid="ref11">11</xref>].</p>
        <p>The next most-cited barrier was self-management difficult to maintain [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref13">13</xref>] (multiple occurrences per article: 13,18), which was identified 7 times (18%). This barrier surrounds the ability of patients to support themselves using the technology. There is a large amount of support necessary for patients to be able to use and maintain a telemedicine program on their own [<xref ref-type="bibr" rid="ref13">13</xref>]. There are also issues identified regarding patients adhering to rules and guidelines surrounding the use of the technology [<xref ref-type="bibr" rid="ref10">10</xref>] and keeping up with these patients from the provider perspective [<xref ref-type="bibr" rid="ref6">6</xref>]. The issues observed with the use of this platform include what to do with borderline readings [<xref ref-type="bibr" rid="ref6">6</xref>] and patients self-titrating their treatments [<xref ref-type="bibr" rid="ref6">6</xref>]. Getting patient buy-in and continual participation is in question [<xref ref-type="bibr" rid="ref5">5</xref>]. <xref ref-type="table" rid="table3">Table 3</xref> illustrates and rank orders the themes from the barriers based on their frequency of occurrence in the literature.</p>
        
        <p>There are questions that remain regarding no long-term results and more areas to address [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref15">15</xref>] (multiple occurrences per article: 6,10) (15%). The lack of long-term studies on this topic has shown a difficulty in the fashioning of responsive clinical processes [<xref ref-type="bibr" rid="ref15">15</xref>] and a lack of data to show comparison with normal management of hypertension [<xref ref-type="bibr" rid="ref11">11</xref>]. In fact, one study showed no difference between a telemedicine group and a normally managed group [<xref ref-type="bibr" rid="ref15">15</xref>]. Many practitioner issues with liability and the mitigation of risk have been raised with the use of telemedicine and its use in the self-management of hypertension [<xref ref-type="bibr" rid="ref13">13</xref>], with potential for information technology issues causing the technology to not be reliable [<xref ref-type="bibr" rid="ref15">15</xref>].</p>
        <p>There is also a perception that the use of telemedicine will result in a long-term added workload commitment [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref18">18</xref>] (multiple occurrences per article: 11,16), as it was identified 5 times (12%). There are significant concerns with time to train staff [<xref ref-type="bibr" rid="ref11">11</xref>] and increased efforts required to train providers on the new technology [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. There are concerns over the perception that the technology is labor intensive and is only available in affluent countries [<xref ref-type="bibr" rid="ref18">18</xref>]. Significant concerns were raised over added workload to already overburdened or time-strapped staff [<xref ref-type="bibr" rid="ref10">10</xref>], increased educational efforts being required [<xref ref-type="bibr" rid="ref18">18</xref>], and unclear time commitments to roll out and keep telemedicine programs implemented [<xref ref-type="bibr" rid="ref10">10</xref>].</p>

<table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Barrier themes associated with the implementation of telemedicine in the self-management of hypertension.</p>
          </caption>
          <table width="600" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="300"/>
            <col width="200"/>
            <col width="100"/>
            <thead>
              <tr valign="top">
                <td>Barriers</td>
                <td>Occurrences</td>
                <td>Frequency (N=40) <break/>n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Lack of evidence</td>
                <td>

[<xref ref-type="bibr" rid="ref3">3</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref4">4</xref>], 
[<xref ref-type="bibr" rid="ref11">11</xref>],
[<xref ref-type="bibr" rid="ref12">12</xref>], 
[<xref ref-type="bibr" rid="ref14">14</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref16">16</xref>] 
</td>
                <td>9 (23)</td>
              </tr>
              <tr valign="top">
                <td>Self-management difficult to maintain</td>
                <td>


[<xref ref-type="bibr" rid="ref5">5</xref>], 
[<xref ref-type="bibr" rid="ref6">6</xref>]<sup>a</sup>,
[<xref ref-type="bibr" rid="ref10">10</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref13">13</xref>]
</td>
                <td>7 (18)</td>
              </tr>
              <tr valign="top">
                <td>No long-term results and more areas to address</td>
                <td>
[<xref ref-type="bibr" rid="ref11">11</xref>],
[<xref ref-type="bibr" rid="ref13">13</xref>]<sup>a</sup>, 
[<xref ref-type="bibr" rid="ref15">15</xref>]<sup>a</sup>
</td>
                <td>6 (15)</td>
              </tr>
              <tr valign="top">
                <td>Long-term added workload commitment</td>
                <td>[<xref ref-type="bibr" rid="ref11">11</xref>], [<xref ref-type="bibr" rid="ref16">16</xref>]<sup>a</sup>, [<xref ref-type="bibr" rid="ref18">18</xref>]<sup>a</sup> </td>
                <td>5 (13)</td>
              </tr>
              <tr valign="top">
                <td>Costly</td>
                <td>[<xref ref-type="bibr" rid="ref4">4</xref>], [<xref ref-type="bibr" rid="ref11">11</xref>], [<xref ref-type="bibr" rid="ref12">12</xref>]</td>
                <td>3 (8)</td>
              </tr>
              <tr valign="top">
                <td>Technology challenges</td>
                <td>[<xref ref-type="bibr" rid="ref5">5</xref>], [<xref ref-type="bibr" rid="ref18">18</xref>]<sup>a</sup></td>
                <td>3 (8)</td>
              </tr>
              <tr valign="top">
                <td>Significant input by general practitioner needed</td>
                <td>[<xref ref-type="bibr" rid="ref6">6</xref>], [<xref ref-type="bibr" rid="ref13">13</xref>]</td>
                <td>2 (5)</td>
              </tr>
              <tr valign="top">
                <td>Variation with providers and systems</td>
                <td>[<xref ref-type="bibr" rid="ref13">13</xref>], [<xref ref-type="bibr" rid="ref14">14</xref>]</td>
                <td>2 (5)</td>
              </tr>
              <tr valign="top">
                <td>Low health literacy level</td>
                <td>[<xref ref-type="bibr" rid="ref4">4</xref>]</td>
                <td>1 (3)</td>
              </tr>
              <tr valign="top">
                <td>Lack of comfort with technology</td>
                <td>[<xref ref-type="bibr" rid="ref4">4</xref>]</td>
                <td>1 (3)</td>
              </tr>
              <tr valign="top">
                <td>Security of data</td>
                <td>[<xref ref-type="bibr" rid="ref4">4</xref>]</td>
                <td>1 (3)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>Denotes multiple occurrences in the same paper.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>

        <p>Another concern among providers is the cost of using such technology [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>], as it was mentioned in 3 papers (8%). Payers for services (such as Medicare) have made little efforts to pay for services provided via telemedicine [<xref ref-type="bibr" rid="ref4">4</xref>], and this is slowing implementation. Furthermore, practitioners are concerned over the cost of the delivery of such services possibly outstripping reimbursement [<xref ref-type="bibr" rid="ref11">11</xref>] and that there might simply be no economic gain to providing services in such a fashion as via telemedicine [<xref ref-type="bibr" rid="ref12">12</xref>]. Initial concerns that the cost for the use of the technology might be wasted also exist, as one study showed similar probabilities for inpatient admission in those who used technology versus those who did not [<xref ref-type="bibr" rid="ref12">12</xref>]. An additional study also showed no significant gains in hypertension control with the addition of technology [<xref ref-type="bibr" rid="ref11">11</xref>]. However, both studies [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>] were specific to the Veterans Administration population, and findings could be specific to this particular population.</p>
        <p>Technology challenges are also a significant barrier [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref18">18</xref>] (multiple occurrences per article: 16), as they are mentioned 3 times (8%). Practitioners are concerned that they lack the resources (technical and financial) to maintain an in-house mHealth service [<xref ref-type="bibr" rid="ref18">18</xref>]. Simple technical challenges [<xref ref-type="bibr" rid="ref5">5</xref>] and the perception that there will be little collaboration among clinical teams in the use of the technology [<xref ref-type="bibr" rid="ref18">18</xref>] are also major concerns.</p>
        <p>Several other barriers were found in the literature, which show concern for implementation on many levels. Significant input needed by general practitioner [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref13">13</xref>] was shown in two papers. The concerns here were that the implementation of such technology would blur professional roles in the treatment milieu [<xref ref-type="bibr" rid="ref13">13</xref>] and that a fear of a significantly increased workload via input exists among these same practitioners [<xref ref-type="bibr" rid="ref6">6</xref>]. A concern with variation with providers and systems [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>] was also noted in two papers. There is limited oversight, regulation, and guidelines over telemedicine applications [<xref ref-type="bibr" rid="ref13">13</xref>], and there is a fear that many applications exist with no oversight at all [<xref ref-type="bibr" rid="ref14">14</xref>], medical or otherwise. The potential exists to put patients in an unsafe condition and/or without medical oversight and attention. Finally, there exists concern over low health literacy levels [<xref ref-type="bibr" rid="ref4">4</xref>], lack of comfort with technology [<xref ref-type="bibr" rid="ref4">4</xref>], and security of data [<xref ref-type="bibr" rid="ref4">4</xref>]. Many patients already have a low health literacy, and adding technology to the mix simply complicates the already difficult to provide care [<xref ref-type="bibr" rid="ref4">4</xref>]. These same patients have a lack of comfortability with technology [<xref ref-type="bibr" rid="ref4">4</xref>], and there are concerns regarding the safety of personal health data [<xref ref-type="bibr" rid="ref4">4</xref>].</p>
      </sec>
      <sec>
        <title>Population</title>
        <p>Hypertension is associated with multiple chronic conditions, including but not limited to diabetes and cardiovascular disease, and there is an ever-increasing need to enhance care to deliver to these individuals [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. Telemedicine broadens access to people unable to reach health services easily [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. Patients’ involvement in health decisions will increase along with access to health information in between visits [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. Remote data collection, monitoring, and cloud computing will allow for care to be delivered from a distance [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref18">18</xref>]. This allows doctors to attend to other patients’ needs that cannot be addressed outside a health care facility. Using telemedicine to attend to the management of patients’ health will vastly reduce problems occurring in face-to-face care [<xref ref-type="bibr" rid="ref17">17</xref>].</p>
      </sec>
      <sec>
        <title>Cost</title>
        <p>Cost is often an argument against telemedicine use in health facilities; however, studies show that implementation such as a Tailored Case Management for Diabetes and Hypertension (TEACH-DM) system allows for rapid implementation at low cost [<xref ref-type="bibr" rid="ref1">1</xref>]. Studies showing the cost-effectiveness of telemedicine point that there is a variation in savings within the short-term use of telemedicine and that this variation can be expected to be steady and to increase in cost-effectiveness over a 2-year period [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>].</p>
        <p>Although no direct government incentives exist for implementing a telemedicine system, the increase in quality and Medicare reimbursement shows steady increases in reimbursement and patient volumes [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref15">15</xref>], and this should be ample incentive in itself to make the move toward this technologically advanced system of care. There are difficulties in understanding why telemedicine is not being heavily implemented throughout the United States despite its cost-effectiveness and research showing positive cost savings and patient outcomes in the long run [<xref ref-type="bibr" rid="ref14">14</xref>]. However, this study can be used by facilities to raise awareness of the cost-saving potential that could result from the implementation of a telemedicine system.</p>
      </sec>
      <sec>
        <title>Perceptions</title>
        <p>Users’ perceptions pose a great level of concern for facilities thinking of adopting a telemedicine program. Users need to understand the value in consistently using telemedicine to assist with self-management of hypertension. The benefits will not be evident immediately [<xref ref-type="bibr" rid="ref13">13</xref>]. Having patients develop a positive perception will make administering a telemedicine program more desirable. Telemedicine has made it more convenient for users to keep track of their health; it allows users to take measurements from home and immediacy of communication [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. By enabling the users to track and record their health status, they feel that they have an increase in knowledge with regard to understanding their health condition [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. This helps to increase patient participation with their own health and modify behaviors that result in an unhealthy lifestyle [<xref ref-type="bibr" rid="ref6">6</xref>,<xref ref-type="bibr" rid="ref11">11</xref>].</p>
        <p>Rejection of using telemedicine is not solely derived from the users’ perceptions; it is heavily influenced by the organization deciding whether implementation is in its best interest. Cost plays a key role in conducting a cost-benefit analysis. Since there is little proven evidence suggesting success in gaining a financial return in using telemedicine for long-term conditions, organizations hesitate on its adoption [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]. Costs may pose an issue if organizations lack proper strategic planning initiatives and fail to adequately address the purpose for adopting telemedicine into their practice. The organization needs to align a telemedicine program in accordance with its mission, vision, and values. Upon alignment, there will be an increase in the quality of care provided to the patients, thus resulting in improved health. Telemedicine has been studied to show an improvement in the quality of life and health of patients who participated in the research studies [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Even with research that supports expanding the use of telemedicine, some clinical trials show no economic gains [<xref ref-type="bibr" rid="ref12">12</xref>]; this poses a challenge for pushing the expansion of telemedicine in organizations.</p>
      </sec>
      <sec>
        <title>Implementation</title>
        <p>Implementation of a telemedicine program relies heavily on the vision being aligned throughout the organization. With cost-effectiveness and rapid implementation models such as TEACH-DM being available, the only barrier is uncertainty. With facilities moving toward implementation of telemedicine models, it is likely for this uncertainty to be demolished [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. Poor planning has been an extreme issue because of the alignment of goals and vision required throughout the organization to be successful in a telemedicine implementation process [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. When a health care facility implements telemedicine models, the benefits realized by the facility will quickly create a domino effect of implementation of telemedicine by other organizations. This is because of the high levels of competition in health care today, requiring facilities to consistently look for ways to reduce cost and increase quality.</p>
      </sec>
      <sec>
        <title>Adopting a Telemedicine system</title>
        <p>Practices may realize the benefits of using telemedicine in the self-management of hypertension after conducting a cost-benefit analysis. This will aid organizations in determining whether the venture is worth adoption. Qualifications for organizations to implement telemedicine programs, at a minimum, are alignment with the mission of the organization and the strategic plan. A common theme throughout the facilitators was an increase in patient health and the quality of care provided. This directly aligns with the goals and requirements established by the PPACA. Legislature is placing an increasing demand on health care organizations to increase the quality of care delivered to patients at a lower cost. Executing a telemedicine program may help alleviate the burden of the PPACA demands and may benefit the health of the population currently living with hypertension. Access is noted to increase with the use of telemedicine by reaching a broader population that may not have easy access to health care resources and transportation, and individuals who require more care such as the elderly.</p>
        <p>These facilitators need to be kept in mind when determining a route to abide by PPACA guidelines. The long-term effects of increases in the health and quality of services that will facilitate financial benefits in the near future should override the initial start-up costs. All decisions are associated with costs and benefits; research indicates that the effectiveness of adopting telemedicine programs is growing, as time unveils the positive outcomes that result from the establishment of these programs.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This review provides a collection of up-to-date data associated with using telemedicine and will assist organizations in weighing the costs and benefits associated with its adoption. A shortfall of this study is that all the papers focused on serving different populations with telemedicine. All the papers were related to using telemedicine to measure high blood pressure, but it was the target populations that varied. Some evaluated using telemedicine to reach people in developing countries, the poor and underserved in developed countries, individuals with diabetes, individuals who only speak Spanish, and individuals who are African American.</p>
        <p>The extraordinarily vast number of uses for telemedicine made research difficult with regard to narrowing down the target population while still having enough data to conduct a systematic review. Telemedicine is relatively new to assist with self-management of chronic conditions, and there is limited research on the subject. Time is required for facilities to gather data information on the effectiveness of using telemedicine for this purpose, and this study was limited to papers published only within the past 5 years.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>Weighing the costs versus the benefits in the creation of a telemedicine program for self-management of hypertension is essential to decide whether it fits the needs of the organization. This review presented a myriad of facilitating factors and barriers through a meta-analysis and systematic review of up-to-date papers from two academic databases. The information presented is helpful in understanding the benefits of telemedicine and its function in an organization.</p>
      </sec>
    </sec>
  </body>
  <back>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">CINAHL</term>
          <def>
            <p>Cumulative Index of Nursing and Allied Health Literature</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">EBSCO</term>
          <def>
            <p>Elton B Stephens Company</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">EKG</term>
          <def>
            <p>electrocardiograph</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">eHealth</term>
          <def>
            <p>electronic health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">HINTS</term>
          <def>
            <p>Hypertension Intervention Nurse Telemedicine Study</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">ICD-10</term>
          <def>
            <p>International Classification of Diseases, Tenth Edition</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">PPACA</term>
          <def>
            <p>Patient Protection and Affordable Care Act of 2010</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">TEACH-DM</term>
          <def>
            <p>Tailored Case Management for Diabetes and Hypertension</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. This paper does not contain any studies with human participants or animals performed by any of the authors. For this type of study, formal consent is not required.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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