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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMI</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Med Inform</journal-id>
      <journal-title>JMIR Medical Informatics</journal-title>
      <issn pub-type="epub">2291-9694</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v5i3e28</article-id>
    <article-id pub-id-type="pmid">28882812</article-id>
    <article-id pub-id-type="doi">10.2196/medinform.7476</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Viewpoint</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Viewpoint</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>Health Information Technology (HIT) Adaptation: Refocusing on the Journey to Successful HIT Implementation</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Eysenbach</surname>
          <given-names>Gunther</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Pino</surname>
          <given-names>Maribel</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Kim</surname>
          <given-names>Jeongeun</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1" corresp="yes">
      <name name-style="western">
        <surname>Yen</surname>
        <given-names>Po-Yin</given-names>
      </name>
      <degrees>RN, PhD</degrees>
      <xref rid="aff1" ref-type="aff">1</xref>
      <address>
        <institution>Washington University in St Louis</institution>
        <institution>Institute for Informatics</institution>
        <addr-line>4444 Forest Park Ave, Suite 6318</addr-line>
        <addr-line>St Louis, MO,</addr-line>
        <country>United States</country>
        <phone>1 314 273 2213</phone>
        <email>yenp@wustl.edu</email>
      </address>  
      <xref rid="aff2" ref-type="aff">2</xref>
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-7061-4185</ext-link></contrib>
      <contrib contrib-type="author" id="contrib2">
        <name name-style="western">
          <surname>McAlearney</surname>
          <given-names>Ann Scheck</given-names>
        </name>
        <degrees>ScD</degrees>
        <xref rid="aff3" ref-type="aff">3</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-9107-5419</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib3">
        <name name-style="western">
          <surname>Sieck</surname>
          <given-names>Cynthia J</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff3" ref-type="aff">3</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-6517-885X</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib4">
        <name name-style="western">
          <surname>Hefner</surname>
          <given-names>Jennifer L</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff3" ref-type="aff">3</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-8083-8038</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib5">
        <name name-style="western">
          <surname>Huerta</surname>
          <given-names>Timothy R</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff3" ref-type="aff">3</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-9978-3564</ext-link>
      </contrib>
    </contrib-group>
    <aff id="aff1">
    <sup>1</sup>
    <institution>Washington University in St Louis</institution>
    <institution>Institute for Informatics</institution>  
    <addr-line>St Louis, MO</addr-line>
    <country>United States</country></aff>
    <aff id="aff2">
      <sup>2</sup>
      <institution>Goldfarb School of Nursing, BJC Healthcare</institution>
      <addr-line>St Louis, MO</addr-line>
      <country>United States</country>
    </aff>
    <aff id="aff3">
    <sup>3</sup>
    <institution>The Ohio State University</institution>
    <institution>Department of Family Medicine</institution>  
    <addr-line>Columbus, OH</addr-line>
    <country>United States</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Po-Yin Yen 
      <email>yenp@wustl.edu</email></corresp>
    </author-notes>
    <pub-date pub-type="collection"><season>Jul-Sep</season><year>2017</year></pub-date>
    <pub-date pub-type="epub">
      <day>07</day>
      <month>09</month>
      <year>2017</year>
    </pub-date>
    <volume>5</volume>
    <issue>3</issue>
    <elocation-id>e28</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>8</day>
        <month>2</month>
        <year>2017</year>
      </date>
      <date date-type="rev-request">
        <day>22</day>
        <month>7</month>
        <year>2017</year>
      </date>
      <date date-type="rev-recd">
        <day>4</day>
        <month>8</month>
        <year>2017</year>
      </date>
      <date date-type="accepted">
        <day>4</day>
        <month>8</month>
        <year>2017</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Po-Yin Yen, Ann Scheck McAlearney, Cynthia J Sieck, Jennifer L Hefner, Timothy R Huerta. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 07.09.2017.</copyright-statement>
    <copyright-year>2017</copyright-year>
    <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Informatics, is properly cited. The complete bibliographic information, a link to the original publication on http://medinform.jmir.org/, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="http://medinform.jmir.org/2017/3/e28/" xlink:type="simple"/>
    <abstract>
      <p>In past years, policies and regulations required hospitals to implement advanced capabilities of certified electronic health records (EHRs) in order to receive financial incentives. This has led to accelerated implementation of health information technologies (HIT) in health care settings. However, measures commonly used to evaluate the success of HIT implementation, such as HIT adoption, technology acceptance, and clinical quality, fail to account for complex sociotechnical variability across contexts and the different trajectories within organizations because of different implementation plans and timelines. We propose a new focus, HIT adaptation, to illuminate factors that facilitate or hinder the connection between use of the EHR and improved quality of care as well as to explore the trajectory of changes in the HIT implementation journey as it is impacted by frequent system upgrades and optimizations. Future research should develop instruments to evaluate the progress of HIT adaptation in both its longitudinal design and its focus on adaptation progress rather than on one cross-sectional outcome, allowing for more generalizability and knowledge transfer.</p>
    </abstract>
    <kwd-group>
      <kwd>health information technology</kwd>
      <kwd>adaptation</kwd>
      <kwd>adoption</kwd>
      <kwd>acceptance</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>Health information technology (HIT) is defined as “the application of information processing involving both computer hardware and software that deals with the storage, retrieval, sharing, and use of health care information, data, and knowledge for communication and decision making” [<xref ref-type="bibr" rid="ref1">1</xref>]. During the past 10 years in the United States, several policies, such as the Health Information Technology for Economic and Clinical Health Act, have led to accelerated HIT adoption and implementation in health care settings, especially implementation of electronic health record (EHR) systems [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. In addition, the Centers for Medicare and Medicaid Services established the EHR incentive program to promote the development of a robust HIT infrastructure, and as part of that effort, released Meaningful Use (MU) criteria in 2010. These criteria require hospitals to implement advanced capabilities of certified EHRs by certain dates in order to receive financial incentives. Other efforts focused on the creation of regional extension centers to facilitate the transition to EHR use through training. MU criteria consist of 3 stages [<xref ref-type="bibr" rid="ref4">4</xref>]: stage 1, begun in 2011, has a focus on data capture and sharing; stage 2, begun in 2014, aims to improve clinical processes with health information exchange, ePrescription, and patient access; and stage 3, in 2017, was recently replaced by Advanced Care Information [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>] due to criticism of the MU program [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>].</p>
      <p>Hospitals have been rapidly responding to these new policies and incentives with large-scale implementations of EHRs during the past few years. Adopting new technology requires the redesign of individual and collective workflows and results in changes in both organizational structure and process [<xref ref-type="bibr" rid="ref9">9</xref>-<xref ref-type="bibr" rid="ref13">13</xref>]. Yet rapid adoption may hinder the interoperability of the EHR system [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. To facilitate appropriate adoption and use, upgrades, redesign, and optimization are needed, including both minor and major changes in EHR infrastructures, functions, interfaces, and workflows. Further, recent studies have shown that there is a close relationship between the speed of adoption and patient safety concerns of clinicians, both across facilities and within different units [<xref ref-type="bibr" rid="ref16">16</xref>-<xref ref-type="bibr" rid="ref18">18</xref>]. EHR implementation could be a distraction from patient care with negative impact on patient outcomes [<xref ref-type="bibr" rid="ref19">19</xref>] and has mixed association with quality improvement [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>].</p>
      <p>At the same time, studies suggest that unsuccessful implementation of HIT systems could be due to poorly designed HIT, poor use of HIT by clinicians, or socioorganizational factors such as goal conflicts, lack of time, or lack of support from colleagues [<xref ref-type="bibr" rid="ref22">22</xref>]. However, these studies lack clarity in their measures [<xref ref-type="bibr" rid="ref23">23</xref>]. This lack of differentiation between technological and human factors thus limits the ability to apply research findings to practice in technology implementation [<xref ref-type="bibr" rid="ref24">24</xref>].</p>
      <p>Given MU regulations, MU requirements have commonly been used as a means to assess HIT implementation success in order to promote essential HIT functionalities [<xref ref-type="bibr" rid="ref4">4</xref>]. For example, MU stage 2 requires providers to have certain HIT functionalities (eg, computerized provider order entry, personal health record, medication reconciliation) in order to continue to participate in the EHR incentive programs [<xref ref-type="bibr" rid="ref25">25</xref>]. However, this approach also creates a ceiling effect, hindering the advancement of innovative utilities. While the MU program may accelerate development and implementation of certain key functions, it also slows down other functionalities [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. By focusing on achieving MU, we risk missing the big picture of health care system changes. Therefore, we propose that there is a need to improve our understanding of how to appropriately assess the performance and success of HIT implementation over time to allow us to generalize to other HIT implementation contexts.</p>
      <sec>
        <title>Measuring Health Information Technology Implementation Success</title>
        <p>Successful HIT implementation is commonly evaluated using measures such as HIT adoption, technology acceptance, and clinical quality. Yet this disparate array of measures fails to account for complex sociotechnical interactions, variability across contexts, and the different trajectories within organizations that exist because of different implementation plans and timelines. Appropriate measurement of HIT implementation thus needs to take into account this variability across organizations and over time but at the same time enable us to generalize the variation across HIT implementation studies in order to inform practice. As a result, the issue of consistent measurement becomes increasingly significant.</p>
        <p>Current measures that exist in the literature include HIT adoption, HIT acceptance, and clinical quality measures (CQMs). The first common measure, HIT adoption, is defined by the EHR MU stages outlined by the Office of the National Coordinator and measures the rate of health care systems having chosen to invest resources toward EHR implementation. It is commonly reported as an adoption rate to reflect the percentage of health care organizations with specific EHR functionalities or capabilities that are meaningful for patient care. In 2013, 59% of hospitals reported at least a basic EHR system, but only 5.1% could meet the MU stage 2 criteria [<xref ref-type="bibr" rid="ref2">2</xref>]. The expectation is that more meaningful use of an EHR system will ultimately result in improved care and more empowered clinicians. In addition, the Healthcare Information and Management Systems Society (HIMSS) measures EHR adoption through the Electronic Medical Record Adoption Model (EMRAM), which categorizes EHR capabilities into an 8-stage scale from stage 0 to stage 7 [<xref ref-type="bibr" rid="ref28">28</xref>]. In 2015, HIMSS Analytics’ Annual Study reported that 27% of hospitals are at stage 6 or above. Although it is helpful to recognize the EHR capabilities across organizations in the nation, it is unclear whether those functions are fully used by clinicians.</p>
        <p>The second approach to measuring implementation success involves HIT acceptance, the extent of individual commitment to use the technology [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref33">33</xref>]. When assessing individual user acceptance, the technology acceptance model (TAM) [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>] is a commonly applied and useful model, albeit with limitations [<xref ref-type="bibr" rid="ref36">36</xref>]. TAM’s predictive power in health care is lower than what has been found in other domains [<xref ref-type="bibr" rid="ref24">24</xref>], and some recommend that the TAM should be integrated with other adoption theories [<xref ref-type="bibr" rid="ref36">36</xref>], particularly those that include variables related to both human and social change processes [<xref ref-type="bibr" rid="ref24">24</xref>].</p>
        <p>CQMs [<xref ref-type="bibr" rid="ref37">37</xref>] are another common metric used to assess the success of HIT [<xref ref-type="bibr" rid="ref38">38</xref>]. However, HIT implementation appears to have little impact on care quality whether measured by patient mortality, adverse drug events, or readmission rates [<xref ref-type="bibr" rid="ref39">39</xref>]. Although CQMs are helpful for assessing the extent to which HIT can be used to monitor the quality of health care services provided, this approach to measurement does not take into account organizational or human factors that could impact HIT implementation.</p>
        <p>Measuring HIT adoption and acceptance alone provides only a limited understanding of HIT success. Both HIT adoption rates and TAM are helpful to understand the status of HIT implementation and acceptance, but they do not inform a strategic plan for promoting successful HIT implementation in a health care organization. CQM as a proxy for HIT success also fails to take into account the organizational context of implementation. In short, as HIT implementation is a process, not an outcome, understanding implementation success requires consideration of the sociotechnical environment in which it takes place.</p>
      </sec>
      <sec>
        <title>Sociotechnical Theory: Improving Our Understanding of Health Information Technology Implementation</title>
        <p>Sociotechnical theory positions people-focused (socio) elements, organizational and human, and information technology elements (technical) as interdependent parts of a system that cannot be studied in isolation and therefore must be evaluated together [<xref ref-type="bibr" rid="ref40">40</xref>]. Sociotechnical theory has been discussed as a theoretical framework that is responsive to the tenets of complex adaptive systems (CAS) [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref44">44</xref>]. When viewed in concert, these 2 theoretical approaches support that interdependent interactions between people and technology within the workplace have both direct impacts, in the classical cause and effect sense, and impacts through feedback, where these same people and technology attenuate, strengthen, distort, halt, or change valence over time [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>].</p>
        <p>Current sociotechnical evaluations involve assessing both the technology and the social contexts where the technology is implemented. A systematic review conducted on EHR implementations revealed that sociotechnical factors complicate HIT deployments [<xref ref-type="bibr" rid="ref46">46</xref>]. Technical features of HIT interact with the social features of a health care work environment. Further, it has been demonstrated that the quality of the implementation process is just as important as the features and capabilities of the system being implemented [<xref ref-type="bibr" rid="ref47">47</xref>-<xref ref-type="bibr" rid="ref49">49</xref>].</p>
        <p>We suggest grounding the theoretical framing of CAS that refers to adaptiveness as “the ability of components of a CAS to change their behavior as a result of interactions with the other components and the surroundings” [<xref ref-type="bibr" rid="ref41">41</xref>]. In shifting the concept of adoption to adaptation, we frame sociotechnological change as occurring over time with system response characterized as the adaptiveness of a health care organization in the context of changes to HIT implementation [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]. For example, technical features are not static; rather they frequently change over time as new versions of the software are promulgated. As such, adoption is not an end state; it is the application of an arbitrary end point to facilitate our understanding. From that perspective, understanding the adaptiveness, or HIT adaptation in this process, is thus significant in our understanding of HIT implementation success [<xref ref-type="bibr" rid="ref50">50</xref>].</p>
      </sec>
      <sec>
        <title>Health Information Technology Adaptation</title>
        <p>Although sociotechnical theory and CAS have been used to explain complexity in health care [<xref ref-type="bibr" rid="ref51">51</xref>], little has been discussed that uses adaptation as a measure to evaluate the success of HIT implementation over time. We thus propose a new focus: adaptation. Adaptation is conceptualized as “a process of modifying existing conditions in an effort to achieve alignment” [<xref ref-type="bibr" rid="ref52">52</xref>] involving workflow redesign, user trainings, and technology maintenance [<xref ref-type="bibr" rid="ref53">53</xref>]. In the context of HIT implementation, refocusing from adoption and acceptance to adaptation illuminates factors that facilitate or hinder the connection between use of the EHR and improved quality of care. Further, by shifting to adaptation, we refocus the question of HIT adoption to one that explores the trajectory of change as an explicit component of the way we measure these issues. <xref ref-type="table" rid="table1">Table 1</xref> presents the definitions of adoption, adaptation, and acceptance as differentiated by Cooper and Zmud [<xref ref-type="bibr" rid="ref53">53</xref>].</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Definitions of adoption, adaptation, and acceptance [<xref ref-type="bibr" rid="ref54">54</xref>].</p>
          </caption>
          <table width="564" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="93"/>
            <col width="450"/>
            <thead>
              <tr valign="top">
                <td>Concept</td>
                <td>Definition</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Adoption</td>
                <td>A decision is reached to invest resources to accommodate the implementation effort.</td>
              </tr>
              <tr valign="top">
                <td>Adaptation</td>
                <td>The innovation is developed, installed, and maintained. Procedures are developed and revised. Members are trained both in the new procedures and in the innovation.</td>
              </tr>
              <tr valign="top">
                <td>Acceptance</td>
                <td>Organizational members are induced to commit to the innovation’s usage.</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>MU criteria [<xref ref-type="bibr" rid="ref54">54</xref>-<xref ref-type="bibr" rid="ref56">56</xref>] and CQMs can be seen as verification and validation steps, respectively, for HIT implementation. In product or system design, evaluation is commonly done via verification and validation. Verification serves as quality control to assess whether a system is in compliance with regulations and specifications. On the other hand, validation is a quality assurance process that establishes evidence to ensure a system accomplishes what was intended. However, no measures have been proposed to assess HIT implementation performance between the steps of system verification and validation. We suggest that this period encompasses the HIT adaptation process, requiring its own measurement approach.</p>
        <p>In <xref ref-type="fig" rid="figure1">Figure 1</xref>, we illustrate the current knowledge gap between meeting the MU criteria and achieving CQMs, linking this conceptually to Donabedian’s well-known structure-process-outcomes model, a quality assessment model presented to evaluate health services outcomes [<xref ref-type="bibr" rid="ref57">57</xref>]. Considering HIT implementation in the context of the Donabedian model, structure refers to HIT resources, which are determined by MU criteria; process refers to clinicians’ use or adaptation of HIT for their use; and outcomes refer to the effects of using HIT for the delivery of health care, as measured by CQMs. In practice, the HIT implementation journey will be impacted by frequent system upgrades and optimizations, leading to performance variability throughout the process. However, by including considerations of sociotechnical factors such as technology acceptance, communication and collaboration, work productivity, training and competency, leadership, and policy, the progress of HIT adaptation could be appropriately assessed.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Health information technology adaptation measures as the process evaluation.</p>
          </caption>
          <graphic xlink:href="medinform_v5i3e28_fig1.jpg" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Theoretical Frameworks to Study Health Information Technology Adaptation</title>
        <p>Two theoretical frameworks provide guidance for HIT adaptation research: the information technology (IT) implementation framework [<xref ref-type="bibr" rid="ref58">58</xref>] and a new sociotechnical model [<xref ref-type="bibr" rid="ref42">42</xref>]. First, the IT implementation framework [<xref ref-type="bibr" rid="ref58">58</xref>] suggests that (1) IT use is complex, multidimensional, and influenced by a variety of factors at individual and organizational levels and (2) success in achieving change is enhanced by active participation of members from the target user group [<xref ref-type="bibr" rid="ref58">58</xref>]. The new sociotechnical model [<xref ref-type="bibr" rid="ref42">42</xref>] now aims to study HIT in complex adaptive health care systems and suggests investigating 8 dimensions: (1) hardware and software computing infrastructure; (2) clinical content; (3) human-computer interface; (4) people; (5) workflow and communication; (6) internal organizational policies, procedures, and culture; (7) external rules, regulations, and pressures; and (8) system measurement and monitoring [<xref ref-type="bibr" rid="ref42">42</xref>]. <xref ref-type="fig" rid="figure2">Figure 2</xref> illustrates our adapted model from the new sociotechnical model [<xref ref-type="bibr" rid="ref42">42</xref>]. We do not include the seventh dimension, “external rules, regulations, and pressures,” as we focus on factors within the organization.</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Adapted from the sociotechnical model [<xref ref-type="bibr" rid="ref43">43</xref>].</p>
          </caption>
          <graphic xlink:href="medinform_v5i3e28_fig2.jpg" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Recommendations for Future Health Information Technology Adaptation Research</title>
        <p>We propose that HIT adaptation research should deploy multilevel and multidimensional evaluation to understand the HIT adaptation progress, drawing from both of these foundational theories. Specifically, HIT adaptation research should focus on developing fundamental and multidimensional facts that can inform the progress of HIT adaptation. Below we describe 4 directions that can drive future HIT adaptation research.</p>
        <sec>
          <title>Develop Appropriate Process Measures</title>
          <p>While the outcome measures (HIT adoption rate, acceptance, and CQMs) have been established, there is a need to develop process measures from individual and organizational perspectives and include multidimensional measures of adaptation to EHRs. These measures will need to incorporate factors such as communication channels, cultural conflict, interdisciplinary team dynamics, user satisfaction, work productivity, cost, and quality [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>].</p>
        </sec>
        <sec>
          <title>Consider the Culture and Context in Which Health Information Technology Is Implemented</title>
          <p>Most HIT adoption or acceptance studies have used individuals or hospitals as the unit of analysis [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]. These findings are informative for identifying associated individual perceptions and experiences as well as hospital demographics. However, additional factors such as the culture of a discipline or a department, the interprofessional or multidisciplinary communication within or across departments, the training received, and workflow at the department level have not been discussed. In particular, while social support has been identified as one of the key factors for acceptance [<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref64">64</xref>], no studies have been conducted at the department or unit level to study this factor.</p>
        </sec>
        <sec>
          <title>Standardize the Definition and Methods for Sociotechnical Studies</title>
          <p>Implementing a new technology into a complex environment is often disruptive, particularly in health care. Sociotechnical evaluations of HIT implementations are supported in both theory and empirically; however, little guidance exists in terms of how to conduct a sociotechnical evaluation [<xref ref-type="bibr" rid="ref65">65</xref>]. Challenges in conducting sociotechnical evaluations include a lack of agreement on the components of the sociotechnical system, possible study designs, and data analysis strategies which may give light to both practical and conceptual challenges [<xref ref-type="bibr" rid="ref65">65</xref>].</p>
        </sec>
        <sec>
          <title>Study Adaptation Longitudinally and Multidimensionally</title>
          <p>Processes are more important to study than outcomes because studying processes allows for generalizability and knowledge transfer beyond the clinical setting where the research was conducted [<xref ref-type="bibr" rid="ref65">65</xref>]. Future studies need to employ longitudinal study designs with multiple data time periods to establish causal relationships [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]. In addition, the HIT evaluation toolkit proposed by the Agency for Healthcare Research and Quality emphasizes the advantages of conducting mixed methods studies to provide important dimensions in an evaluation study [<xref ref-type="bibr" rid="ref68">68</xref>]. Thus, future HIT research studies should be designed as mixed methods sociotechnical evaluations focused on exploring the dynamic relationship between technology and social factors over time [<xref ref-type="bibr" rid="ref65">65</xref>].</p>
        </sec>
      </sec>
      <sec>
        <title>Conclusion</title>
        <p>Measuring HIT adaptation can provide a more thorough understanding of the connection between HIT use and health care outcomes. Our ability to advance our understanding is predicated on good evaluation models, notably in the area of a health organization’s overall performance. As the sociotechnical environment remains a confounding problem influencing our understanding of the generalizability of research findings about HIT implementation success, there is a need to integrate issues exacerbated by workarounds, poorly designed interfaces, suboptimal functionality, and the sheer complexity of systems that contribute to HIT adoption issues as well as consider the idiosyncrasies across contexts. However, existing evaluation models are not supportive of a greater understanding of the phenomenon itself. This paper is therefore presented to provide a new perspective to shift the focus from adoption to adaptation. Future research should develop instruments to evaluate the progress of HIT adaptation in both its longitudinal design and its focus on adaptation progress rather than on a single outcome, allowing for more generalizability and knowledge transfer.</p>
      </sec>
    </sec>
  </body>
  <back>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">CAS</term>
          <def>
            <p>complex adaptive system</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">CQM</term>
          <def>
            <p>clinical quality measure</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">EMRAM</term>
          <def>
            <p>electronic medical record adoption model</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">HER</term>
          <def>
            <p>electronic health record</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">HIMSS</term>
          <def>
            <p>Healthcare Information and Management Systems Society</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">HIT</term>
          <def>
            <p>health information technology</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">IT</term>
          <def>
            <p>information technology</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">MU</term>
          <def>
            <p>Meaningful Use</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">TAM</term>
          <def>
            <p>technology acceptance model</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This work was supported by the Agency for Healthcare Research and Quality (R21HS024767).</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="book">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Thompson</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Brailer</surname>
            <given-names>D</given-names>
          </name>
        </person-group>
        <source>Health IT Strategic Framework</source>  
        <year>2004</year>  
        <publisher-loc>Washington</publisher-loc>
        <publisher-name>US Department of Health and Human Services</publisher-name></nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Adler-Milstein</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>DesRoches</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Furukawa</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Worzala</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Charles</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Kralovec</surname>
            <given-names>P</given-names>
          </name>
        </person-group>
        <article-title>More than half of US hospitals have at least a basic EHR but stage 2 criteria remain challenging for most</article-title>
        <source>Health Aff (Millwood)</source>  
        <year>2014</year> </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>DesRoches</surname>
            <given-names>CM</given-names>
          </name>
          <name name-style="western">
            <surname>Charles</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Furukawa</surname>
            <given-names>MF</given-names>
          </name>
          <name name-style="western">
            <surname>Joshi</surname>
            <given-names>MS</given-names>
          </name>
          <name name-style="western">
            <surname>Kralovec</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Mostashari</surname>
            <given-names>F</given-names>
          </name>
          <name name-style="western">
            <surname>Worzala</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Jha</surname>
            <given-names>AK</given-names>
          </name>
        </person-group>
        <article-title>Adoption of electronic health records grows rapidly, but fewer than half of US hospitals had at least a basic system in 2012</article-title>
        <source>Health Aff (Millwood)</source>  
        <year>2013</year>  
        <month>08</month>  
        <volume>32</volume>  
        <issue>8</issue>  
        <fpage>1478</fpage>  
        <lpage>1485</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://content.healthaffairs.org/cgi/pmidlookup?view=long&#38;pmid=23840052"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1377/hlthaff.2013.0308</pub-id>
        <pub-id pub-id-type="medline">23840052</pub-id>
        <pub-id pub-id-type="pii">hlthaff.2013.0308</pub-id></nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>US Centers for Medicare &#38; Medicaid Services</collab>
        </person-group>
        <source>Electronic health records (EHR) incentive programs 2017</source>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.cms.gov/Regulations-and-Guidance/Legislation/EHRIncentivePrograms/index.html?redirect=/EHRIncentivePrograms">https://www.cms.gov/Regulations-and-Guidance/Legislation/EHRIncentivePrograms/index.html?redirect=/EHRIncentivePrograms</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp1G1AHt"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>DeSalvo</surname>
            <given-names>KB</given-names>
          </name>
          <name name-style="western">
            <surname>Salavitt</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <source>Moving toward improved care through information</source>  
        <year>2016</year>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.healthit.gov/buzz-blog/from-the-onc-desk/moving-improved-care-information/">https://www.healthit.gov/buzz-blog/from-the-onc-desk/moving-improved-care-information/</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp1KbyVJ"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Manchikanti</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Helm</surname>
            <given-names>IS</given-names>
          </name>
          <name name-style="western">
            <surname>Calodney</surname>
            <given-names>AK</given-names>
          </name>
          <name name-style="western">
            <surname>Hirsch</surname>
            <given-names>JA</given-names>
          </name>
        </person-group>
        <article-title>Merit-based incentive payment system: meaningful changes in the final rule brings cautious optimism</article-title>
        <source>Pain Physician</source>  
        <year>2017</year>  
        <volume>20</volume>  
        <issue>1</issue>  
        <fpage>E1</fpage>  
        <lpage>E12</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.painphysicianjournal.com/linkout?issn=1533-3159&#38;vol=20&#38;page=E1"/>
        </comment>  
        <pub-id pub-id-type="medline">28072793</pub-id></nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Manchikanti</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Benyamin</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Falco</surname>
            <given-names>F</given-names>
          </name>
          <name name-style="western">
            <surname>Hirsch</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Metamorphosis of medicine in the United States: a carrot and stick policy of electronic medical records</article-title>
        <source>Pain Physician</source>  
        <year>2014</year>  
        <volume>17</volume>  
        <issue>6</issue>  
        <fpage>e671</fpage>  
        <lpage>e680</lpage> </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Manchikanti</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Hirsch</surname>
            <given-names>JA</given-names>
          </name>
        </person-group>
        <article-title>A case for restraint of explosive growth of health information technology: first, do no harm</article-title>
        <source>Pain Physician</source>  
        <year>2015</year>  
        <volume>18</volume>  
        <issue>3</issue>  
        <fpage>E293</fpage>  
        <lpage>E298</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.painphysicianjournal.com/linkout?issn=1533-3159&#38;vol=18&#38;page=E293"/>
        </comment>  
        <pub-id pub-id-type="medline">26000676</pub-id></nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ammenwerth</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Gräber</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Herrmann</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Bürkle</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>König</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Evaluation of health information systems—problems and challenges</article-title>
        <source>Int J Med Inform</source>  
        <year>2003</year>  
        <month>09</month>  
        <volume>71</volume>  
        <issue>2-3</issue>  
        <fpage>125</fpage>  
        <lpage>135</lpage>  
        <pub-id pub-id-type="medline">14519405</pub-id>
        <pub-id pub-id-type="pii">S138650560300131X</pub-id></nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Singh</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Singh</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Singh</surname>
            <given-names>DR</given-names>
          </name>
          <name name-style="western">
            <surname>Singh</surname>
            <given-names>G</given-names>
          </name>
        </person-group>
        <article-title>Improvement of workflow and processes to ease and enrich meaningful use of health information technology</article-title>
        <source>Adv Med Educ Pract</source>  
        <year>2013</year>  
        <volume>4</volume>  
        <fpage>231</fpage>  
        <lpage>236</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://dx.doi.org/10.2147/AMEP.S53307"/>
        </comment>  
        <pub-id pub-id-type="doi">10.2147/AMEP.S53307</pub-id>
        <pub-id pub-id-type="medline">24235855</pub-id>
        <pub-id pub-id-type="pii">amep-4-231</pub-id>
        <pub-id pub-id-type="pmcid">PMC3826941</pub-id></nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>McAlearney</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Hefner</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Sieck</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Rizer</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Huerta</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Evidence-based management of ambulatory electronic health record system implementation: an assessment of conceptual support and qualitative evidence</article-title>
        <source>Int J Med Inform</source>  
        <year>2014</year>  
        <volume>83</volume>  
        <issue>7</issue>  
        <fpage>484</fpage>  
        <lpage>494</lpage> </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>McAlearney</surname>
            <given-names>AS</given-names>
          </name>
          <name name-style="western">
            <surname>Hefner</surname>
            <given-names>JL</given-names>
          </name>
          <name name-style="western">
            <surname>Sieck</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Rizer</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Huerta</surname>
            <given-names>TR</given-names>
          </name>
        </person-group>
        <article-title>Fundamental issues in implementing an ambulatory care electronic health record</article-title>
        <source>J Am Board Fam Med</source>  
        <year>2015</year>  
        <volume>28</volume>  
        <issue>1</issue>  
        <fpage>55</fpage>  
        <lpage>64</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.jabfm.org/cgi/pmidlookup?view=long&#38;pmid=25567823"/>
        </comment>  
        <pub-id pub-id-type="doi">10.3122/jabfm.2015.01.140078</pub-id>
        <pub-id pub-id-type="medline">25567823</pub-id>
        <pub-id pub-id-type="pii">28/1/55</pub-id></nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>McAlearney</surname>
            <given-names>AS</given-names>
          </name>
          <name name-style="western">
            <surname>Song</surname>
            <given-names>PH</given-names>
          </name>
          <name name-style="western">
            <surname>Robbins</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Hirsch</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Jorina</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Kowalczyk</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Chisolm</surname>
            <given-names>D</given-names>
          </name>
        </person-group>
        <article-title>Moving from good to great in ambulatory electronic health record implementation</article-title>
        <source>J Healthc Qual</source>  
        <year>2010</year>  
        <volume>32</volume>  
        <issue>5</issue>  
        <fpage>41</fpage>  
        <lpage>50</lpage>  
        <pub-id pub-id-type="doi">10.1111/j.1945-1474.2010.00107.x</pub-id>
        <pub-id pub-id-type="medline">20854358</pub-id></nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Studeny</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Coustasse</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Personal health records: is rapid adoption hindering interoperability?</article-title>
        <source>Perspect Health Inf Manag</source>  
        <year>2014</year>  
        <volume>11</volume>  
        <fpage>1e</fpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/25214822"/>
        </comment>  
        <pub-id pub-id-type="medline">25214822</pub-id>
        <pub-id pub-id-type="pmcid">PMC4142513</pub-id></nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>D'Amore</surname>
            <given-names>JD</given-names>
          </name>
          <name name-style="western">
            <surname>Mandel</surname>
            <given-names>JC</given-names>
          </name>
          <name name-style="western">
            <surname>Kreda</surname>
            <given-names>DA</given-names>
          </name>
          <name name-style="western">
            <surname>Swain</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Koromia</surname>
            <given-names>GA</given-names>
          </name>
          <name name-style="western">
            <surname>Sundareswaran</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Alschuler</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Dolin</surname>
            <given-names>RH</given-names>
          </name>
          <name name-style="western">
            <surname>Mandl</surname>
            <given-names>KD</given-names>
          </name>
          <name name-style="western">
            <surname>Kohane</surname>
            <given-names>IS</given-names>
          </name>
          <name name-style="western">
            <surname>Ramoni</surname>
            <given-names>RB</given-names>
          </name>
        </person-group>
        <article-title>Are Meaningful Use Stage 2 certified EHRs ready for interoperability? Findings from the SMART C-CDA Collaborative</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2014</year>  
        <volume>21</volume>  
        <issue>6</issue>  
        <fpage>1060</fpage>  
        <lpage>1068</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/24970839"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1136/amiajnl-2014-002883</pub-id>
        <pub-id pub-id-type="medline">24970839</pub-id>
        <pub-id pub-id-type="pii">amiajnl-2014-002883</pub-id>
        <pub-id pub-id-type="pmcid">PMC4215060</pub-id></nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ford</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Pettit</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Silvera</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Huerta</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>EMR implementation speed: patient safety culture paradox</article-title>
        <source>J Healthc Inform Manage</source>  
        <year>2014</year>  
        <volume>28</volume>  
        <issue>3</issue>  
        <fpage>24</fpage>  
        <lpage>31</lpage> </nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Sakata</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Stephenson</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Mulanax</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Bierman</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>McGrath</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Scholl</surname>
            <given-names>G</given-names>
          </name>
        </person-group>
        <article-title>Professional and interprofessional differences in electronic health records use and recognition of safety issues in critically ill patients</article-title>
        <source>J Interprof Care</source>  
        <year>2016</year>  
        <fpage>1</fpage>  
        <lpage>7</lpage> </nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Lorenzi</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Novak</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Weiss</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Gadd</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Unertl</surname>
            <given-names>K</given-names>
          </name>
        </person-group>
        <article-title>Crossing the implementation chasm: a proposal for bold action</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2008</year>  
        <volume>15</volume>  
        <issue>3</issue>  
        <fpage>290</fpage>  
        <lpage>296</lpage> </nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Afonso</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Alfonso</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Morgan</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Short-term impact of meaningful use stage 1 implementation: a comparison of health outcomes in 2 primary care clinics</article-title>
        <source>J Ambul Care Manage</source>  
        <year>2017</year> </nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Grinspan</surname>
            <given-names>Z</given-names>
          </name>
          <name name-style="western">
            <surname>Bao</surname>
            <given-names>Y</given-names>
          </name>
          <name name-style="western">
            <surname>Edwards</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Johnson</surname>
            <given-names>P</given-names>
          </name>
          <name name-style="western">
            <surname>Kaushal</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Kern</surname>
            <given-names>L</given-names>
          </name>
        </person-group>
        <article-title>Medicaid stage 1 meaningful use EHR incentive payments are associated with higher quality but not improvements in quality</article-title>
        <source>Am J Med Qual</source>  
        <year>2016</year>  
        <month>10</month>  
        <day>13</day>  
        <pub-id pub-id-type="doi">10.1177/1062860616673905</pub-id>
        <pub-id pub-id-type="medline">27738129</pub-id>
        <pub-id pub-id-type="pii">1062860616673905</pub-id></nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Levine</surname>
            <given-names>DM</given-names>
          </name>
          <name name-style="western">
            <surname>Healey</surname>
            <given-names>MJ</given-names>
          </name>
          <name name-style="western">
            <surname>Wright</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Bates</surname>
            <given-names>DW</given-names>
          </name>
          <name name-style="western">
            <surname>Linder</surname>
            <given-names>JA</given-names>
          </name>
          <name name-style="western">
            <surname>Samal</surname>
            <given-names>L</given-names>
          </name>
        </person-group>
        <article-title>Changes in the quality of care during progress from stage 1 to stage 2 of Meaningful Use</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2017</year>  
        <month>12</month>  
        <day>01</day>  
        <volume>24</volume>  
        <issue>2</issue>  
        <fpage>394</fpage>  
        <lpage>397</lpage>  
        <pub-id pub-id-type="doi">10.1093/jamia/ocw127</pub-id>
        <pub-id pub-id-type="medline">27567000</pub-id>
        <pub-id pub-id-type="pii">ocw127</pub-id></nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kaplan</surname>
            <given-names>B</given-names>
          </name>
        </person-group>
        <article-title>Evaluating informatics applications—some alternative approaches: theory, social interactionism, and call for methodological pluralism</article-title>
        <source>Int J Med Inform</source>  
        <year>2001</year>  
        <month>11</month>  
        <volume>64</volume>  
        <issue>1</issue>  
        <fpage>39</fpage>  
        <lpage>56</lpage>  
        <pub-id pub-id-type="medline">11673101</pub-id>
        <pub-id pub-id-type="pii">S1386-5056(01)00184-8</pub-id></nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Wears</surname>
            <given-names>RL</given-names>
          </name>
          <name name-style="western">
            <surname>Berg</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Computer technology and clinical work: still waiting for Godot</article-title>
        <source>JAMA</source>  
        <year>2005</year>  
        <month>03</month>  
        <day>09</day>  
        <volume>293</volume>  
        <issue>10</issue>  
        <fpage>1261</fpage>  
        <lpage>1263</lpage>  
        <pub-id pub-id-type="doi">10.1001/jama.293.10.1261</pub-id>
        <pub-id pub-id-type="medline">15755949</pub-id>
        <pub-id pub-id-type="pii">293/10/1261</pub-id></nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ward</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>The application of technology acceptance and diffusion of innovation models in healthcare informatics</article-title>
        <source>Health Policy and Technology</source>  
        <year>2013</year>  
        <volume>2</volume>  
        <fpage>222</fpage>  
        <lpage>228</lpage> </nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>US Centers for Medicare &#38; Medicaid Services</collab>
        </person-group>
        <source>Step 5: achieve meaningful use stage 2</source>  
        <year>2014</year>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.healthit.gov/providers-professionals/step-5-achieve-meaningful-use-stage-2">https://www.healthit.gov/providers-professionals/step-5-achieve-meaningful-use-stage-2</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp2WB4bu"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Botta</surname>
            <given-names>MD</given-names>
          </name>
          <name name-style="western">
            <surname>Cutler</surname>
            <given-names>DM</given-names>
          </name>
        </person-group>
        <article-title>Meaningful use: floor or ceiling?</article-title>
        <source>Healthc (Amst)</source>  
        <year>2014</year>  
        <month>03</month>  
        <volume>2</volume>  
        <issue>1</issue>  
        <fpage>48</fpage>  
        <lpage>52</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.hjdsi.2013.12.011</pub-id>
        <pub-id pub-id-type="medline">26250089</pub-id>
        <pub-id pub-id-type="pii">S2213-0764(14)00008-6</pub-id></nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Nakamura</surname>
            <given-names>MM</given-names>
          </name>
          <name name-style="western">
            <surname>Harper</surname>
            <given-names>MB</given-names>
          </name>
          <name name-style="western">
            <surname>Castro</surname>
            <given-names>AV</given-names>
          </name>
          <name name-style="western">
            <surname>Yu</surname>
            <given-names>FB</given-names>
          </name>
          <name name-style="western">
            <surname>Jha</surname>
            <given-names>AK</given-names>
          </name>
        </person-group>
        <article-title>Impact of the meaningful use incentive program on electronic health record adoption by US children's hospitals</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2015</year>  
        <month>03</month>  
        <volume>22</volume>  
        <issue>2</issue>  
        <fpage>390</fpage>  
        <lpage>398</lpage>  
        <pub-id pub-id-type="doi">10.1093/jamia/ocu045</pub-id>
        <pub-id pub-id-type="medline">25755126</pub-id>
        <pub-id pub-id-type="pii">ocu045</pub-id></nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>HIMSS Analytics</collab>
        </person-group>
        <source>EMR adoption model</source>  
        <year>2009</year>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.himssanalytics.org/hc_providers/emr_adoption.asp">http://www.himssanalytics.org/hc_providers/emr_adoption.asp</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp2k3f5a"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Phichitchaisopa</surname>
            <given-names>N</given-names>
          </name>
          <name name-style="western">
            <surname>Naenna</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Factors affecting the adoption of healthcare information technology</article-title>
        <source>EXCLI J</source>  
        <year>2013</year>  
        <volume>12</volume>  
        <fpage>413</fpage>  
        <lpage>436</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/26417235"/>
        </comment>  
        <pub-id pub-id-type="medline">26417235</pub-id>
        <pub-id pub-id-type="pmcid">PMC4566918</pub-id></nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Venkatesh</surname>
            <given-names>V</given-names>
          </name>
          <name name-style="western">
            <surname>Sykes</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Zhang</surname>
            <given-names>X</given-names>
          </name>
        </person-group>
        <article-title>“Just what the doctor ordered:” a revised UTAUT for EMR system adoption and use by doctors</article-title>
        <year>2011</year>  
        <conf-name>Proceedings of the 44th Hawaii International Conference on System Sciences</conf-name>
        <conf-date>2011</conf-date>
        <conf-loc>Kauai</conf-loc></nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Patel</surname>
            <given-names>V</given-names>
          </name>
          <name name-style="western">
            <surname>Jamoom</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Hsiao</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Furukawa</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Buntin</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>Variation in electronic health record adoption and readiness for meaningful use: 2008-2011</article-title>
        <source>J Gen Intern Med</source>  
        <year>2013</year>  
        <month>07</month>  
        <volume>28</volume>  
        <issue>7</issue>  
        <fpage>957</fpage>  
        <lpage>964</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/23371416"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1007/s11606-012-2324-x</pub-id>
        <pub-id pub-id-type="medline">23371416</pub-id>
        <pub-id pub-id-type="pmcid">PMC3682025</pub-id></nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Steininger</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Stiglbauer</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Baumgartner</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Engleder</surname>
            <given-names>B</given-names>
          </name>
        </person-group>
        <article-title>Factors explaining physicians' acceptance of electronic health records</article-title>
        <year>2014</year>  
        <conf-name>47th Hawaii International Conference on System Science</conf-name>
        <conf-date>2014</conf-date>
        <conf-loc>Waikoloa</conf-loc></nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Liu</surname>
            <given-names>Z</given-names>
          </name>
          <name name-style="western">
            <surname>Min</surname>
            <given-names>Q</given-names>
          </name>
          <name name-style="western">
            <surname>Ji</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <article-title>A comprehensive review of research in IT adoption</article-title>
        <year>2008</year>  
        <conf-name>4th International Conference on Wireless Communications, Networking and Mobile Computing</conf-name>
        <conf-date>2008</conf-date>
        <conf-loc>Dalian</conf-loc></nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Davis</surname>
            <given-names>F</given-names>
          </name>
        </person-group>
        <article-title>User acceptance of information technologyystem characteristics, user perceptions, and behavioral impacts</article-title>
        <source>Int J Man Mach Stud</source>  
        <year>1993</year>  
        <volume>38</volume>  
        <issue>3</issue>  
        <fpage>475</fpage>  
        <lpage>487</lpage> </nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Davis</surname>
            <given-names>FD</given-names>
          </name>
        </person-group>
        <article-title>Perceived usefulness, perceived ease of use, and user acceptance of information technology</article-title>
        <source>MIS Quarterly</source>  
        <year>1989</year>  
        <volume>13</volume>  
        <issue>3</issue>  
        <fpage>318</fpage>  
        <lpage>340</lpage> </nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gangwar</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Date</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Raoot</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Review of IT adoption: insights from recent technologies</article-title>
        <source>J Enterprise Inform Manag</source>  
        <year>2014</year>  
        <volume>27</volume>  
        <issue>4</issue>  
        <fpage>488</fpage>  
        <lpage>502</lpage> </nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>Center for Medicare and Medicaid Services</collab>
        </person-group>
        <source>Clinical quality measures</source>  
        <year>2014</year>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.cms.gov/Regulations-and-Guidance/Legislation/EHRIncentivePrograms/2014_ClinicalQualityMeasures.html">http://www.cms.gov/Regulations-and-Guidance/Legislation/EHRIncentivePrograms/2014_ClinicalQualityMeasures.html</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp3iQexe"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Spetz</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Burgess</surname>
            <given-names>JF</given-names>
          </name>
          <name name-style="western">
            <surname>Phibbs</surname>
            <given-names>CS</given-names>
          </name>
        </person-group>
        <article-title>The effect of health information technology implementation in Veterans Health Administration hospitals on patient outcomes</article-title>
        <source>Healthc (Amst)</source>  
        <year>2014</year>  
        <month>03</month>  
        <volume>2</volume>  
        <issue>1</issue>  
        <fpage>40</fpage>  
        <lpage>47</lpage>  
        <pub-id pub-id-type="doi">10.1016/j.hjdsi.2013.12.009</pub-id>
        <pub-id pub-id-type="medline">26250088</pub-id>
        <pub-id pub-id-type="pii">S2213-0764(14)00006-2</pub-id></nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Agha</surname>
            <given-names>L</given-names>
          </name>
        </person-group>
        <article-title>The effects of health information technology on the costs and quality of medical care</article-title>
        <source>J Health Econ</source>  
        <year>2014</year>  
        <month>03</month>  
        <volume>34</volume>  
        <fpage>19</fpage>  
        <lpage>30</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/24463141"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1016/j.jhealeco.2013.12.005</pub-id>
        <pub-id pub-id-type="medline">24463141</pub-id>
        <pub-id pub-id-type="pii">S0167-6296(13)00172-0</pub-id>
        <pub-id pub-id-type="pmcid">PMC4415264</pub-id></nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Robertson</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Cresswell</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Takian</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Petrakaki</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Crowe</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Cornford</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Implementation and adoption of nationwide electronic health records in secondary care in England: qualitative analysis of interim results from a prospective national evaluation</article-title>
        <source>Brit Med J</source>  
        <year>2010</year>  
        <fpage>341</fpage> </nlm-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <nlm-citation citation-type="confproc">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Wang</surname>
            <given-names>Y</given-names>
          </name>
          <name name-style="western">
            <surname>Gu</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Zhou</surname>
            <given-names>Z</given-names>
          </name>
        </person-group>
        <article-title>Complex adaptive socio-technical systems theory view of ubiquitous computing systems research</article-title>
        <year>2014</year>  
        <conf-name>Ubiquitous Computing and Ambient Intelligence Personalisation and User Adapted Services</conf-name>
        <conf-date>2014</conf-date>
        <conf-loc>Belfast</conf-loc>
        <fpage>216</fpage>  
        <lpage>223</lpage> </nlm-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Sittig</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Singh</surname>
            <given-names>H</given-names>
          </name>
        </person-group>
        <article-title>A new sociotechnical model for studying health information technology in complex adaptive healthcare systems</article-title>
        <source>Qual Safety Healthc</source>  
        <year>2010</year>  
        <volume>19</volume>  
        <fpage>68</fpage>  
        <lpage>74</lpage> </nlm-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ellis</surname>
            <given-names>B</given-names>
          </name>
          <name name-style="western">
            <surname>Herbert</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <article-title>Complex adaptive systems (CAS): an overview of key elements, characteristics and application to management theory</article-title>
        <source>Inform Prim Care</source>  
        <year>2011</year>  
        <volume>19</volume>  
        <issue>1</issue>  
        <fpage>33</fpage>  
        <lpage>37</lpage> </nlm-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Harrison</surname>
            <given-names>MI</given-names>
          </name>
          <name name-style="western">
            <surname>Koppel</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Bar-Lev</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <article-title>Unintended consequences of information technologies in health care—an interactive sociotechnical analysis</article-title>
        <source>J Am Med Inform Assoc</source>  
        <year>2007</year>  
        <volume>14</volume>  
        <issue>5</issue>  
        <fpage>542</fpage>  
        <lpage>549</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/17600093"/>
        </comment>  
        <pub-id pub-id-type="doi">10.1197/jamia.M2384</pub-id>
        <pub-id pub-id-type="medline">17600093</pub-id>
        <pub-id pub-id-type="pii">M2384</pub-id>
        <pub-id pub-id-type="pmcid">PMC1975796</pub-id></nlm-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ellis</surname>
            <given-names>B</given-names>
          </name>
        </person-group>
        <article-title>Complexity in practice: understanding primary care as a complex adaptive system</article-title>
        <source>Inform Prim Care</source>  
        <year>2010</year>  
        <volume>18</volume>  
        <issue>2</issue>  
        <fpage>135</fpage>  
        <lpage>140</lpage> </nlm-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Gagnon</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Desmartis</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Labrecque</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Car</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Pagliari</surname>
            <given-names>C</given-names>
          </name>
          <name name-style="western">
            <surname>Pluye</surname>
            <given-names>P</given-names>
          </name>
        </person-group>
        <article-title>Systematic review of factors influencing the adoption of information and communication technologies by healthcare professionals</article-title>
        <source>J Med Syst</source>  
        <year>2012</year>  
        <volume>36</volume>  
        <issue>1</issue>  
        <fpage>241</fpage>  
        <lpage>277</lpage> </nlm-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Patel</surname>
            <given-names>V</given-names>
          </name>
          <name name-style="western">
            <surname>Kannampallil</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Human factors and health information technology: current challenges and future directions</article-title>
        <source>Yearb Med Inform</source>  
        <year>2014</year>  
        <volume>9</volume>  
        <issue>1</issue>  
        <fpage>58</fpage>  
        <lpage>66</lpage> </nlm-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Coiera</surname>
            <given-names>E</given-names>
          </name>
        </person-group>
        <article-title>Putting the technical back into socio-technical systems research</article-title>
        <source>Int J Med Inform</source>  
        <year>2007</year>  
        <volume>76</volume>  
        <fpage>S98</fpage>  
        <lpage>S103</lpage> </nlm-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Balka</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Tolar</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Coates</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Whitehouse</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <article-title>Socio-technical issues and challenges in implementing safe patient handovers: insights from ethnographic case studies</article-title>
        <source>Int J Med Inform</source>  
        <year>2013</year>  
        <volume>82</volume>  
        <issue>12</issue>  
        <fpage>e345</fpage>  
        <lpage>e357</lpage> </nlm-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ludwick</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Doucette</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Adopting electronic medical records in primary care: lessons learned from health information systems implementation experience in seven countries</article-title>
        <source>Int J Med Inform</source>  
        <year>2009</year>  
        <volume>78</volume>  
        <issue>1</issue>  
        <fpage>22</fpage>  
        <lpage>31</lpage> </nlm-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kannampallil</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Schauer</surname>
            <given-names>G</given-names>
          </name>
          <name name-style="western">
            <surname>Cohen</surname>
            <given-names>T</given-names>
          </name>
          <name name-style="western">
            <surname>Patel</surname>
            <given-names>V</given-names>
          </name>
        </person-group>
        <article-title>Considering complexity in healthcare systems</article-title>
        <source>J Biomed Inform</source>  
        <year>2011</year>  
        <volume>44</volume>  
        <issue>6</issue>  
        <fpage>943</fpage>  
        <lpage>937</lpage> </nlm-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Majchrzak</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Rice</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Malhotra</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>King</surname>
            <given-names>N</given-names>
          </name>
        </person-group>
        <article-title>Technology adaptation: the case of a computer-supported inter-organizational virtual team</article-title>
        <source>MIS Quarterly</source>  
        <year>2000</year>  
        <volume>24</volume>  
        <issue>4</issue>  
        <fpage>569</fpage>  
        <lpage>600</lpage> </nlm-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Cooper</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Zmud</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>Information technology implementation research: a technological diffusion approach</article-title>
        <source>Manag Sci</source>  
        <year>1990</year>  
        <volume>36</volume>  
        <fpage>123</fpage>  
        <lpage>139</lpage> </nlm-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>Center for Medicare and Medicaid Services</collab>
        </person-group>
        <source>EHR Incentive Programs</source>  
        <year>2014</year>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://www.cms.gov/Regulations-and-Guidance/Legislation/EHRIncentivePrograms/Stage_2.html">http://www.cms.gov/Regulations-and-Guidance/Legislation/EHRIncentivePrograms/Stage_2.html</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp4YJfxD"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Blumenthal</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Tavenner</surname>
            <given-names>M</given-names>
          </name>
        </person-group>
        <article-title>The “meaningful use” regulation for electronic health records</article-title>
        <source>New Engl J Med</source>  
        <year>2010</year>  
        <volume>363</volume>  
        <issue>6</issue>  
        <fpage>501</fpage>  
        <lpage>504</lpage> </nlm-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Marcotte</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Seidman</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Trudel</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Berwick</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Blumenthal</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Mostashari</surname>
            <given-names>F</given-names>
          </name>
        </person-group>
        <article-title>Achieving meaningful use of health information technology: a guide for physicians to the EHR incentive programs</article-title>
        <source>Arch Intern Med</source>  
        <year>2012</year>  
        <volume>172</volume>  
        <issue>9</issue>  
        <fpage>731</fpage>  
        <lpage>736</lpage> </nlm-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Donabedian</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>The quality of medical care</article-title>
        <source>Science</source>  
        <year>1978</year>  
        <month>05</month>  
        <day>26</day>  
        <volume>200</volume>  
        <issue>4344</issue>  
        <fpage>856</fpage>  
        <lpage>864</lpage>  
        <pub-id pub-id-type="medline">417400</pub-id></nlm-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Kukafka</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Johnson</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Linfante</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Allegrante</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Grounding a new information technology implementation framework in behavioral science: a systematic analysis of the literature on IT use</article-title>
        <source>J Biomed Inform</source>  
        <year>2003</year>  
        <volume>36</volume>  
        <issue>3</issue>  
        <fpage>218</fpage>  
        <lpage>227</lpage> </nlm-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>eHealth Observatory and School of Health Information Science University of Victoria</collab>
        </person-group>
        <source>Benefits evaluation indicators, technical report</source>  
        <year>2012</year>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.infoway-inforoute.ca/en/component/edocman/450-benefits-evaluation-indicators-technical-report-version-2-0/view-document?Itemid=101">https://www.infoway-inforoute.ca/en/component/edocman/450-benefits-evaluation-indicators-technical-report-version-2-0/view-document?Itemid=101</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp5635Ep"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>Agency for Healthcare Research and Quality</collab>
        </person-group>
        <source>Health IT evaluation measures</source>  
        <year>2014</year>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://healthit.ahrq.gov/health-it-tools-and-resources/evaluation-resources/health-it-evaluation-toolkit-and-evaluation-measures-quick-reference">https://healthit.ahrq.gov/health-it-tools-and-resources/evaluation-resources/health-it-evaluation-toolkit-and-evaluation-measures-quick-reference</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp58tchb"/>
        </comment> </nlm-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Jamoom</surname>
            <given-names>E</given-names>
          </name>
          <name name-style="western">
            <surname>Patel</surname>
            <given-names>V</given-names>
          </name>
          <name name-style="western">
            <surname>Furukawa</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>King</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>EHR adopters vs non-adopters: impacts of, barriers to, and federal initiatives for EHR adoption</article-title>
        <source>Healthcare</source>  
        <year>2014</year>  
        <volume>2</volume>  
        <fpage>33</fpage>  
        <lpage>39</lpage> </nlm-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Price</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Singer</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>J</given-names>
          </name>
        </person-group>
        <article-title>Adopting electronic medical records: are they just electronic paper records?</article-title>
        <source>Canadian Fam Physician</source>  
        <year>2013</year>  
        <volume>59</volume>  
        <issue>7</issue>  
        <fpage>e322</fpage>  
        <lpage>e329</lpage> </nlm-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Ash</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Sittig</surname>
            <given-names>D</given-names>
          </name>
          <name name-style="western">
            <surname>Guappone</surname>
            <given-names>K</given-names>
          </name>
          <name name-style="western">
            <surname>Dykstra</surname>
            <given-names>R</given-names>
          </name>
          <name name-style="western">
            <surname>Richardson</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Wright</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Recommended practices for computerized clinical decision support and knowledge management in community settings: a qualitative study</article-title>
        <source>BMC</source>  
        <year>2012</year>  
        <volume>12</volume>  
        <fpage>6</fpage> </nlm-citation>
      </ref>
      <ref id="ref64">
        <label>64</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hsiao</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Chang</surname>
            <given-names>H</given-names>
          </name>
          <name name-style="western">
            <surname>Chen</surname>
            <given-names>R</given-names>
          </name>
        </person-group>
        <article-title>A study of factors affecting acceptance of hospital information systems: a nursing perspective</article-title>
        <source>J Nurs Res</source>  
        <year>2011</year>  
        <volume>19</volume>  
        <issue>2</issue>  
        <fpage>150</fpage>  
        <lpage>160</lpage> </nlm-citation>
      </ref>
      <ref id="ref65">
        <label>65</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Cresswell</surname>
            <given-names>KM</given-names>
          </name>
          <name name-style="western">
            <surname>Sheikh</surname>
            <given-names>A</given-names>
          </name>
        </person-group>
        <article-title>Undertaking sociotechnical evaluations of health information technologies</article-title>
        <source>Inform Prim Care</source>  
        <year>2014</year>  
        <volume>21</volume>  
        <issue>2</issue>  
        <fpage>78</fpage>  
        <lpage>83</lpage>  
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://dx.doi.org/10.14236/jhi.v21i2.54"/>
        </comment>  
        <pub-id pub-id-type="doi">10.14236/jhi.v21i2.54</pub-id>
        <pub-id pub-id-type="medline">24841408</pub-id></nlm-citation>
      </ref>
      <ref id="ref66">
        <label>66</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Hameed</surname>
            <given-names>M</given-names>
          </name>
          <name name-style="western">
            <surname>Counsell</surname>
            <given-names>S</given-names>
          </name>
          <name name-style="western">
            <surname>Swift</surname>
            <given-names>S</given-names>
          </name>
        </person-group>
        <article-title>A conceptual model for the process of IT innovation adoption in organizations</article-title>
        <source>J Engineer Technol Manag</source>  
        <year>2012</year>  
        <volume>29</volume>  
        <issue>3</issue>  
        <fpage>358</fpage>  
        <lpage>390</lpage> </nlm-citation>
      </ref>
      <ref id="ref67">
        <label>67</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Spaulding</surname>
            <given-names>A</given-names>
          </name>
          <name name-style="western">
            <surname>Gamm</surname>
            <given-names>L</given-names>
          </name>
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>J</given-names>
          </name>
          <name name-style="western">
            <surname>Menser</surname>
            <given-names>T</given-names>
          </name>
        </person-group>
        <article-title>Multiproject interdependencies in health systems management: a longitudinal qualitative study</article-title>
        <source>Health Care Manag Rev</source>  
        <year>2014</year>  
        <volume>39</volume>  
        <issue>1</issue>  
        <fpage>31</fpage>  
        <lpage>40</lpage> </nlm-citation>
      </ref>
      <ref id="ref68">
        <label>68</label>
        <nlm-citation citation-type="web">
        <person-group person-group-type="author">
          <collab>Agency for Healthcare Research and Quality</collab>
        </person-group>
        <source>Health Information Technology Evaluation Toolkit</source>  
        <year>2009</year>  
        <access-date>2017-08-18</access-date>
        <comment>
          <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://healthit.ahrq.gov/sites/default/files/docs/page/Evaluation%20Toolkit%20Revised%20Version.pdf">https://healthit.ahrq.gov/sites/default/files/docs/page/Evaluation%20Toolkit%20Revised%20Version.pdf</ext-link>
          <ext-link ext-link-type="webcite" xlink:href="6sp5r81OY"/>
        </comment> </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
