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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMI</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Med Inform</journal-id>
      <journal-title>JMIR Medical Informatics</journal-title>
      <issn pub-type="epub">2291-9694</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v4i2e19</article-id>
    <article-id pub-id-type="pmid">27251559</article-id>
    <article-id pub-id-type="doi">10.2196/medinform.5525</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Original Paper</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Original Paper</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>Adoption Factors of the Electronic Health Record: A Systematic Review</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Eysenbach</surname>
          <given-names>Gunther</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Cutrona</surname>
          <given-names>Sarah</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Emani</surname>
          <given-names>Srinivas</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1" corresp="yes" equal-contrib="yes">
      <name name-style="western">
        <surname>Kruse</surname>
        <given-names>Clemens Scott</given-names>
      </name>
      <degrees>MBA, MSIT, MHA, PhD</degrees>
      <xref rid="aff1" ref-type="aff">1</xref>
      <address>
        <institution>Texas State University</institution>
        <institution>School of Health Administration</institution>
        <addr-line>601 University Drive</addr-line>
        <addr-line>HPB, 250</addr-line>
        <addr-line>San Marcos, TX, 78230</addr-line>
        <country>United States</country>
        <phone>1 210 355 4742</phone>
        <fax>1 512 245 8712</fax>
        <email>scottkruse@txstate.edu</email>
      </address>  
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-7636-1086</ext-link></contrib>
      <contrib contrib-type="author" id="contrib2" equal-contrib="yes">
        <name name-style="western">
          <surname>Kothman</surname>
          <given-names>Krysta</given-names>
        </name>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-2115-9606</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib3" equal-contrib="yes">
        <name name-style="western">
          <surname>Anerobi</surname>
          <given-names>Keshia</given-names>
        </name>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-1277-7621</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib4" equal-contrib="yes">
        <name name-style="western">
          <surname>Abanaka</surname>
          <given-names>Lillian</given-names>
        </name>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-8545-6896</ext-link>
      </contrib>
    </contrib-group>
    <aff id="aff1">
    <sup>1</sup>
    <institution>Texas State University</institution>
    <institution>School of Health Administration</institution>  
    <addr-line>San Marcos, TX</addr-line>
    <country>United States</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Clemens Scott Kruse 
      <email>scottkruse@txstate.edu</email></corresp>
    </author-notes>
    <pub-date pub-type="collection"><season>Apr-Jun</season><year>2016</year></pub-date>
    <pub-date pub-type="epub">
      <day>01</day>
      <month>06</month>
      <year>2016</year>
    </pub-date>
    <volume>4</volume>
    <issue>2</issue>
    <elocation-id>e19</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>14</day>
        <month>1</month>
        <year>2016</year>
      </date>
      <date date-type="rev-request">
        <day>2</day>
        <month>3</month>
        <year>2016</year>
      </date>
      <date date-type="rev-recd">
        <day>3</day>
        <month>3</month>
        <year>2016</year>
      </date>
      <date date-type="accepted">
        <day>21</day>
        <month>3</month>
        <year>2016</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Clemens Scott Kruse, Krysta Kothman, Keshia Anerobi, Lillian Abanaka. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 01.06.2016.</copyright-statement>
    <copyright-year>2016</copyright-year>
    <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Informatics, is properly cited. The complete bibliographic information, a link to the original publication on http://medinform.jmir.org/, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="http://medinform.jmir.org/2016/2/e19/" xlink:type="simple"/>
    <abstract>
      <sec sec-type="Background">
        <title>Background</title>
        <p>The Health Information Technology for Economic and Clinical Health (HITECH) was a significant piece of legislation in America that served as a catalyst for the adoption of health information technology. Following implementation of the HITECH Act, Health Information Technology (HIT) experienced broad adoption of Electronic Health Records (EHR), despite skepticism exhibited by many providers for the transition to an electronic system. A thorough review of EHR adoption facilitator and barriers provides ongoing support for the continuation of EHR implementation across various health care structures, possibly leading to a reduction in associated economic expenditures.</p>
      </sec>
      <sec sec-type="Objective">
        <title>Objective</title>
        <p>The purpose of this review is to compile a current and comprehensive list of facilitators and barriers to the adoption of the EHR in the United States.</p>
      </sec>
      <sec sec-type="Methods">
        <title>Methods</title>
        <p>Authors searched Cumulative Index of Nursing and Allied Health Literature (CINAHL) and MEDLINE, 01/01/2012–09/01/2015, core clinical/academic journals, MEDLINE full text, and evaluated only articles germane to our research objective. Team members selected a final list of articles through consensus meetings (n=31). Multiple research team members thoroughly read each article to confirm applicability and study conclusions, thereby increasing validity.</p>
      </sec>
      <sec sec-type="Results">
        <title>Results</title>
        <p>Group members identified common facilitators and barriers associated with the EHR adoption process. In total, 25 adoption facilitators were identified in the literature occurring 109 times; the majority of which were efficiency, hospital size, quality, access to data, perceived value, and ability to transfer information. A total of 23 barriers to adoption were identified in the literature, appearing 95 times; the majority of which were cost, time consuming, perception of uselessness, transition of data, facility location, and implementation issues.</p>
      </sec>
      <sec sec-type="Conclusions">
        <title>Conclusions</title>
        <p>The 25 facilitators and 23 barriers to the adoption of the EHR continue to reveal a preoccupation on cost, despite incentives in the HITECH Act. Limited financial backing and outdated technology were also common barriers frequently mentioned during data review. Future public policy should include incentives commensurate with those in the HITECH Act to maintain strong adoption rates.</p>
      </sec>
    </abstract>
    <kwd-group>
      <kwd>electronic health record</kwd>
      <kwd>information technology</kwd>
      <kwd>HITECH Act</kwd>
      <kwd>health information technology</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Currently in the United States, expenditures associated with health care average 17.5% of the gross domestic product (GDP) [<xref ref-type="bibr" rid="ref1">1</xref>]. The Health Information Technology for Economic and Clinical Health (HITECH) Act was initiated in 2009 and, as described by Samuel (2014), implemented goals of “widespread” adoption of Electronic Health Records (EHRs) that should realize nationwide savings in the health care industry [<xref ref-type="bibr" rid="ref2">2</xref>]. Although much research exists in support of the policy makers’ agenda tied to the HITECH Act, the widespread adoption process leaves many providers reluctant to move forward due to concerns of financial pressures, technology limitations, and potential unintended errors related to limited knowledge of the EHR [<xref ref-type="bibr" rid="ref3">3</xref>]. There is plenty of literature that supports the idea that adoption of Health Information Technology (HIT), specifically the EHR, presents great potential value to the health care industry in our nation [<xref ref-type="bibr" rid="ref3">3</xref>]. Through the implementation of HIT, patients, providers, and intermediaries can expect “efficiency, effectiveness, and safety of health care” [<xref ref-type="bibr" rid="ref4">4</xref>]. The potential for great savings, efficiency, and quality through the adoption of the EHR created high expectations from the federal government, and President Bush even expected ubiquitous adoption by the year 2014 [<xref ref-type="bibr" rid="ref5">5</xref>]. However, only 55% of nationwide providers had fulfilled the HITECH Act requests by the end of 2014 [<xref ref-type="bibr" rid="ref5">5</xref>]. With financial-savings estimates ranging from $77-$371 billion throughout the country following broad implementation, adoption of the EHR is essential for all who are involved [<xref ref-type="bibr" rid="ref6">6</xref>]. A thorough review of EHR adoption facilitator and barrier factors provides ongoing support for the continuation of EHR implementation across various health care structures, possibly leading to a reduction in associated economic expenditures. Several researchers have examined adoption factors and barriers, but a gap in the literature exists that places these factors into an affinity diagram to identify those facilitators and barriers to adoption most often cited [<xref ref-type="bibr" rid="ref7">7</xref>].</p>
      </sec>
      <sec>
        <title>Objective</title>
        <p>The purpose of this review is to compile a current and comprehensive list of facilitators and barriers to the adoption of the EHR in the United States, and create an affinity diagram that orders these items by frequency of occurrence. Although frequency of occurrence in the literature does not necessarily identify the most important factors, it may help policy makers prioritize levels of effort for maximum effectiveness and the results of this review should enable future studies to explore the significance and order of importance.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Search</title>
        
        <p>We searched for research on the topic of both facilitators and barriers to adoption of the EHR. A quick look at the Medical Subject Heading (MeSH) in PubMed terms shows no clear association with the term “adoption” in the sense of “selection”. As a result, a combination of Boolean operators and several similar terms were employed in a manner that would be likely to capture of the desired articles. Additionally, two terms are closely associated with the electronic records: the electronic health record, and the electronic medical record (EMR). While these terms are distinct in the HIT field, they are often used interchangeably throughout the literature, so both were included in the search terms. We also accepted studies and reviews on the topic, but only if they were published in academic journals or indexed in MEDLINE.</p>
      </sec>
      <sec>
        <title>Data</title>
        
        <p>Articles for this review were gathered from two separate databases: Cumulative Index of Nursing and Allied Health Literature (CINAHL) Academic Search Complete via Ebson B Stephens Company (EBSCO Host), and PubMed (MEDLINE Complete). Search criteria were not limited to any specific focus. Instead, we searched for EHR or EMR adoption factors and barriers to adoption in patient care facilities in general. An iterative, nonlinear search string was created through PubMed and a similar string was used with Boolean operators in CINAHL.</p>
        <p><xref ref-type="fig" rid="figure1">Figure 1</xref> illustrates the search process, with the associated inclusion and exclusion criteria. As depicted, we narrowed the focus of the review to 1/1/2012–9/1/2015, core clinical/academic journals, full text. From this process, 60 articles were identified. The beginning of 2012 was chosen because it is one year after incentives for Meaningful Use incentives became available. The entire process of article selection is illustrated in <xref ref-type="fig" rid="figure1">Figure 1</xref> (Literature review process). Authors agreed ahead of time on acceptable criteria for articles included in the review in an effort to increase the inter-rater reliability.</p>

 <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>The search process with inclusion and exclusion criteria.</p>
          </caption>
          <graphic xlink:href="medinform_v4i2e19_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>Using the criteria agreed upon, we independently read abstracts of these articles to determine if the research was germane to our topic, then we discussed our findings to reach consensus. Once consensus was reached, we examined the references in the remaining 30 articles to identify additional research that was not captured with our search string; one additional article was identified for the sample through this process. The final sample included 31 articles. The inter-rater reliability for the initial selection of titles was very good (kappa=.789). Our group of five divided the articles into sets that overlapped. We met again to discuss the merits of these articles, and through this meeting, we identified common themes in the literature of both facilitators and barriers to adoption. Consensus was reached on all 31 articles (kappa=1.0, excellent).</p>
        <p>We decided to include systematic reviews in the sample because the data in the reviews would help validate our review. A total of three reviews were included and integrated into a literature matrix with the other articles. The literature matrix consisted of date of publication, journal, authors, titles, study designs, data sources, and pertinent details on both facilitators and barriers to the adoption of the EHR. Studies and reviews were sorted by date of publication (newest to oldest), by author (alphabetical), and they were assigned numbers that correspond to those in the references. The numbers are not sequential in <xref ref-type="table" rid="table1">Table 1</xref> because several of the articles were used in the background section, so their numbers are lower than the start of those called up in the review. From this matrix, multiple affinity diagrams were created that illustrate the frequency of facilitators, barriers, study designs, and sources of data.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Summary of Findings</title>
        <p>We identified 31 unique publications that addressed facilitators and/or barriers to adoption of the EHR. Our analysis identified 25 facilitators for and 23 barriers to adoption. A portion of our literature matrix is included in <xref ref-type="table" rid="table1">Table 1</xref>. Many factors that some studies listed as facilitators were listed by others as barriers.</p>       
        
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Summarized facilitators and barriers.</p>
          </caption>
          <table width="611" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="115"/>
            <col width="180"/>
            <col width="260"/>
            <thead>
              <tr valign="top">
                <td>Authors</td>
                <td>Facilitators</td>
                <td>Barriers</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Kruse CS, et al [<xref ref-type="bibr" rid="ref8">8</xref>]</td>
                <td>Access to information <break/>Error reduction <break/>Transfer of information <break/>Long-run cost savings <break/>Clinical and administrative efficiency <break/>Project planning <break/>Security <break/>Time savings <break/>Staff retention</td>
                <td>Initial cost <break/>User perceptions <break/>Implementation problems <break/>External factors <break/>Training <break/>Cultural change <break/>Future upgrades <break/>Necessary maintenance</td>
              </tr>
              <tr valign="top">
                <td>Cucciniello M, et al [<xref ref-type="bibr" rid="ref9">9</xref>]</td>
                <td>Commitment promotion <break/>Role defining <break/>System impacts assessments</td>
                <td>Change processes</td>
              </tr>
              <tr valign="top">
                <td>McCullough JM, et al [<xref ref-type="bibr" rid="ref10">10</xref>]</td>
                <td>Availability of clinical data <break/>Support from management <break/>Competition</td>
                <td>Competition</td>
              </tr>
              <tr valign="top">
                <td>Tang, et al [<xref ref-type="bibr" rid="ref11">11</xref>]</td>
                <td>Availability of RECs</td>
                <td>none specified</td>
              </tr>
              <tr valign="top">
                <td>Abramson EL, et al [<xref ref-type="bibr" rid="ref12">12</xref>]</td>
                <td>Size of hospital (bed size)</td>
                <td>Cost <break/>Lack of incentive <break/>Lack of interoperability <break/>Competitiveness <break/>Ongoing cost of maintenance</td>
              </tr>
              <tr valign="top">
                <td>Ben-Zion R et al [<xref ref-type="bibr" rid="ref13">13</xref>]</td>
                <td>Executive management support <break/>Alignment with firm strategy <break/>Economic competiveness <break/>Knowledge management <break/>Patient empowerment</td>
                <td>Cost-benefit asymmetry <break/>Lack of standard protocols for data exchange <break/>Uncertainty over implementation cost <break/>User resistance <break/>Breaches in security <break/>Patient privacy</td>
              </tr>
              <tr valign="top">
                <td>D'Amore JD, et al [<xref ref-type="bibr" rid="ref14">14</xref>]</td>
                <td>Continuity of care document</td>
                <td>Omission or misuse of LOINC <break/>Excess precision in timestamps <break/>Omission or misuse of UCUM in meds <break/>Omission or misuse of RxNorm <break/>Omission or misuse of dose amount <break/>Omission or misuse of allergic reactions <break/>Omission or misuse of allergy severity <break/>Omission or misuse of dose frequency <break/>Omission of result interpretation <break/>Omission of result reference range</td>
              </tr>
              <tr valign="top">
                <td>Jones EB, Furukawa MF [<xref ref-type="bibr" rid="ref15">15</xref>]</td>
                <td>Engage patients and family in their care <break/>Improve care coordination <break/>Improve population and public health <break/>Quality recognition</td>
                <td>Health centers with large share of Hispanics and Blacks had lower adoption rates <break/>Centers located in rural areas <break/>Health center size, income status and region <break/>Health centers with larger share of patients whose family incomes were below poverty level had lower rate of EHR adoption</td>
              </tr>
              <tr valign="top">
                <td>Kruse CS, et al [<xref ref-type="bibr" rid="ref7">7</xref>]</td>
                <td>Size of hospital (bed size) <break/>Competiveness <break/>Urban locations <break/>Users cognitive ability <break/>User attitude toward information <break/>Workflow impact <break/>Communication among users</td>
                <td>Patients’ age <break/>Rural locations <break/>Computer anxiety</td>
              </tr>
              <tr valign="top">
                <td>Samuel CA [<xref ref-type="bibr" rid="ref2">2</xref>]</td>
                <td>Patients enrolled in Medicare or Medicaid <break/>Metropolitan status <break/>Increased financial incentives</td>
                <td>Health professional shortage areas <break/>Minority concentration</td>
              </tr>
              <tr valign="top">
                <td>Sockolow PS, et al [<xref ref-type="bibr" rid="ref16">16</xref>]</td>
                <td>Increase in productivity <break/>Improved clinical notes <break/>Reduced time to reimbursement <break/>Improved communication among staff</td>
                <td>Incomplete medication information <break/>Incomplete hospital-stay information</td>
              </tr>
              <tr valign="top">
                <td>Ancker JS, et al [<xref ref-type="bibr" rid="ref17">17</xref>]</td>
                <td>Monetary incentives <break/>Efficiency (fewer providers needed) <break/>Efficiency (practice sites) <break/>Effectiveness (fewer patients) <break/>Practice size</td>
                <td>Cost <break/>Lack of tech assistance</td>
              </tr>
              <tr valign="top">
                <td>Audet AM, et al [<xref ref-type="bibr" rid="ref18">18</xref>]</td>
                <td>Size of practice <break/>Ability to search for patients by diagnosis <break/>Ability to list patients overdue for preventative care <break/>Sort patients by specific laboratory results</td>
                <td>Cost <break/>lack of experience <break/>Lack of tech-support infrastructure</td>
              </tr>
              <tr valign="top">
                <td>Baillie CA, et al [<xref ref-type="bibr" rid="ref19">19</xref>]</td>
                <td>Reduce readmission rates</td>
                <td>Existing data may not serve well in a predictive model</td>
              </tr>
              <tr valign="top">
                <td>Cheung SK, et al [<xref ref-type="bibr" rid="ref20">20</xref>]</td>
                <td>Efficiency <break/>Reduction of medical errors <break/>Ability to share patient information in public sector <break/>Eliminate need to store paper records <break/>Eliminate illegibility of practice partners</td>
                <td>Patient unfriendliness <break/>Limited consultant time <break/>Cost concerns <break/>Computer use more time consuming <break/>Concerns on data migrations from paper to system <break/>Insufficient space for computer installation</td>
              </tr>
              <tr valign="top">
                <td>Georgiou A, et al [<xref ref-type="bibr" rid="ref21">21</xref>]</td>
                <td>Laboratory order forms contained bar codes for easier ordering <break/>A unique bar code for patient details <break/>Unique bar codes for each test <break/>A test order episode barcode</td>
                <td>EMR test order problems <break/>Handwritten request on an EMR order <break/>Order number problem <break/>Multiple forms <break/>EMR order incorrect <break/>Change of test <break/>Add-on test <break/>No information provided <break/>Longer data entry time</td>
              </tr>
              <tr valign="top">
                <td>Hamid F, Cline TW [<xref ref-type="bibr" rid="ref5">5</xref>]</td>
                <td>EHR satisfaction increased when users understood the benefits <break/>Supportive management <break/>Training programs</td>
                <td>Cost <break/>Perceived lack of usefulness and provider autonomy <break/>Time consuming</td>
              </tr>
              <tr valign="top">
                <td>Iqbual U, et al [<xref ref-type="bibr" rid="ref22">22</xref>]</td>
                <td>Perceived usefulness <break/>Perceived ease to use <break/>Computer self-efficacy <break/>Security <break/>Intention to use</td>
                <td>Clinics with high number of outpatient visits <break/>Subjective norm</td>
              </tr>
              <tr valign="top">
                <td>Kirkendall ES, et al [<xref ref-type="bibr" rid="ref23">23</xref>]</td>
                <td>Communication <break/>Job satisfaction <break/>Quality and patient data <break/>Quality and safety of patient care <break/>Employee understanding and support <break/>Organizational support <break/>The “Rights” of patient care</td>
                <td>Transition of data</td>
              </tr>
              <tr valign="top">
                <td>Middleton B, et al [<xref ref-type="bibr" rid="ref24">24</xref>]</td>
                <td>Monetary incentives <break/>Improve effectiveness <break/>Improve efficiency</td>
                <td>Increased training burden <break/>Alert fatigue</td>
              </tr>
              <tr valign="top">
                <td>Patel V, et al [<xref ref-type="bibr" rid="ref25">25</xref>]</td>
                <td>Financial incentives <break/>Size of practice</td>
                <td>Lack of interoperability standards</td>
              </tr>
              <tr valign="top">
                <td>Shen X, et al [<xref ref-type="bibr" rid="ref26">26</xref>]</td>
                <td>Size of practice</td>
                <td>Cost <break/>Lack of integration with other systems <break/>Lack of national guidelines for implementation</td>
              </tr>
              <tr valign="top">
                <td>Xierali IM, et al [<xref ref-type="bibr" rid="ref27">27</xref>]</td>
                <td>Health maintenance organizations more likely to adopt EHR <break/>Those with faculty status more likely to adopt EHR</td>
                <td>Medically underserved locations less likely to adopt EHR <break/>Geographic health professional shortage areas less likely to adopt EHR <break/>International medical graduates less likely to adopt EHR <break/>Group practice/solo practice and small practice physicians less likely to adopt EHR</td>
              </tr>
              <tr valign="top">
                <td>Menachemi N, et al [<xref ref-type="bibr" rid="ref28">28</xref>]</td>
                <td>HMO penetration into market</td>
                <td>Competition <break/>Low income patients</td>
              </tr>
              <tr valign="top">
                <td>DesRoches CM, et al [<xref ref-type="bibr" rid="ref29">29</xref>]</td>
                <td>Size of facility <break/>Incentives</td>
                <td>Cost <break/>Size of facility</td>
              </tr>
              <tr valign="top">
                <td>Decker SL, et al [<xref ref-type="bibr" rid="ref30">30</xref>]</td>
                <td>Size of organization</td>
                <td>Age</td>
              </tr>
              <tr valign="top">
                <td>Hudson JS, et al [<xref ref-type="bibr" rid="ref31">31</xref>]</td>
                <td>Hospital setting <break/>Improved outcomes <break/>Reduce duplicative tests <break/>Integrate levels of care <break/>Improve communication <break/>Greater readability</td>
                <td>Cost</td>
              </tr>
              <tr valign="top">
                <td>Jamoom E, et al [<xref ref-type="bibr" rid="ref32">32</xref>]</td>
                <td>Age <break/>Size of practice <break/>Enhanced patient care</td>
                <td>none specified</td>
              </tr>
              <tr valign="top">
                <td>Leu MG, et al [<xref ref-type="bibr" rid="ref33">33</xref>]</td>
                <td>Size of practice</td>
                <td>Cost <break/>Productivity <break/>Customizability (right fit)</td>
              </tr>
              <tr valign="top">
                <td>Linder JA et al [<xref ref-type="bibr" rid="ref34">34</xref>]</td>
                <td>Better for structured documenters <break/>Better for free text documenters</td>
                <td>Decrease in quality of care for dictator note takers</td>
              </tr>
              <tr valign="top">
                <td>Ramaiah M, et al [<xref ref-type="bibr" rid="ref35">35</xref>]</td>
                <td>Workflow can be optimized <break/>Access to electronic information <break/>e-prescriptions</td>
                <td>Workflow often ad-hoc in nature <break/>Check-backs of scripts still time consuming <break/>Medical literacy of clerks inhibits smooth scheduling <break/>Information must still be verified <break/>Lack of IT experience of staff <break/>Uncertainty of time <break/>Uncertainty of cost</td>
              </tr>
              <tr valign="top">
                <td>Rea S, et al [<xref ref-type="bibr" rid="ref36">36</xref>]</td>
                <td>Secondary use of data <break/>Natural language processing</td>
                <td>Privacy and security</td>
              </tr>
              <tr valign="top">
                <td>Ronquillo JG [<xref ref-type="bibr" rid="ref37">37</xref>]</td>
                <td>Genome-associated care <break/>Reduce error <break/>More efficient care <break/>More effective care <break/>Control costs</td>
                <td>Privacy and security</td>
              </tr>
              <tr valign="top">
                <td>Wang T, Biederman S [<xref ref-type="bibr" rid="ref38">38</xref>]</td>
                <td>Reduce error <break/>Improve quality of care <break/>Deliver more effective care</td>
                <td>Cost</td>
              </tr>
              <tr valign="top">
                <td>Soares N, et al [<xref ref-type="bibr" rid="ref39">39</xref>]</td>
                <td>Improve clinician satisfaction <break/>Improve clinical efficiency <break/>Improve parent satisfaction</td>
                <td>Cost <break/>Technical assistance <break/>Organizational barriers <break/>No consensus among peer organizations</td>
              </tr>
              <tr valign="top">
                <td>Hacker K, et al [<xref ref-type="bibr" rid="ref40">40</xref>]</td>
                <td> </td>
                <td>Disruption of care <break/>Lack of interoperability <break/>Disruption of workflow <break/>Increased patient-cycle time <break/>Breakdown in communication <break/>Fragmentation of information <break/>Inflexible processes <break/>Physician overload</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        
        
      </sec>
      <sec>
        <title>Facilitators</title>
        <p>As depicted in <xref ref-type="table" rid="table1">Table 1</xref>, various articles used similar, but not exact terms. While compiling the results into <xref ref-type="table" rid="table2">Table 2</xref>, several factors were similar enough to be combined. <italic>User perception/perceived usefulness</italic> [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref31">31</xref>], was combined with <italic>user attitude toward information</italic> [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref36">36</xref>]. <xref ref-type="table" rid="table2">Table 2</xref> is organized to rank order each factor that serves as a facilitator for EHR adoption. The center column identifies the article in which the factor was observed–the numbers correspond to the number assigned in order of mention (Introduction), followed by the order analyzed (<xref ref-type="table" rid="table1">Table 1</xref>), and the numbers match those assigned to these articles in the references. The last column numbers the occurrences. There were a total of 25 facilitators, and they were found a total of 109 times in the literature.</p>
        
        
        <p>From the facilitators listed, <italic>efficiency, organization size, and improved quality</italic> were listed 12%, 9%, and 9% of the total occurrences of all facilitators mentioned in the literature, respectively. <italic>Access to patient care, user perception/perceived usefulness, ability to transfer information</italic> and <italic>incentives</italic> were identified in the literature 7%, 6%, 6%, and 5%, respectively. <italic>Error reduction, time savings</italic>, and <italic>competitiveness</italic> were all listed 4% of all occurrences. The rest of the barriers were mentioned three or less times, so we grouped them into a category of miscellaneous.</p>
      </sec>
      <sec>
        <title>Barriers</title>
        <p>As depicted in <xref ref-type="table" rid="table1">Table 1</xref>, various articles used similar, but not the exact terms. While compiling the results into <xref ref-type="table" rid="table3">Table 3</xref>, several barriers were similar enough to be combined. This occurred more often in the barrier table than the facilitator table. <italic>Interoperability</italic> was combined with <italic>no standard protocol for data exchange</italic> [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. <italic>Training</italic> was combined with <italic>maintenance and upgrades</italic> [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. The barrier of <italic>Staff shortages</italic> was combined with <italic>overworked</italic> [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. <italic>Privacy</italic> was combined with <italic>security</italic> [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]. <italic>Lack of infrastructure</italic> was combined with <italic>lack of space</italic> [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref20">20</xref>]. Finally, <italic>missing data</italic> was combined with <italic>omission of result, interpretation,</italic> and <italic>omission of result reference range</italic> [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref21">21</xref>]. There were a total of 23 barriers, and they were found a total of 95 times in the literature.</p>

<table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Facilitators identified in the literature.</p>
          </caption>
          <table width="601" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="212"/>
            <col width="258"/>
            <col width="100"/>
            <thead>
              <tr valign="top">
                <td>Facilitators</td>
                <td>Occurrences by article reference number</td>
                <td>Total occurrences</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Efficiency</td>
                <td>2,7,8,15,16,17,19,20,23,25,29,31,33</td>
                <td>13</td>
              </tr>
              <tr valign="bottom">
                <td>Hospital size<sup>a</sup></td>
                <td>7,12,16,24,25,26,28,29,31,32</td>
                <td>11</td>
              </tr>
              <tr valign="top">
                <td>Improved quality</td>
                <td>15,18,21,22,23,26,30,31,32,33</td>
                <td>10</td>
              </tr>
              <tr valign="top">
                <td>Access to patient data</td>
                <td>8,10,15,19,20,22,28,29</td>
                <td>8</td>
              </tr>
              <tr valign="top">
                <td>User perception/perceived usefulness</td>
                <td>5,7,9,21,22,26,30</td>
                <td>7</td>
              </tr>
              <tr valign="top">
                <td>Ability to transfer information</td>
                <td>8,9,19,28,29,30</td>
                <td>6</td>
              </tr>
              <tr valign="top">
                <td>Communication</td>
                <td>7,8,15,22,30</td>
                <td>5</td>
              </tr>
              <tr valign="top">
                <td>Executive management support</td>
                <td>1,5,9,10,13</td>
                <td>6</td>
              </tr>
              <tr valign="top">
                <td>Incentives</td>
                <td>2,16,21,23</td>
                <td>5</td>
              </tr>
              <tr valign="top">
                <td>Error reduction</td>
                <td>8,19,31,32</td>
                <td>4</td>
              </tr>
              <tr valign="top">
                <td>Time savings</td>
                <td>5,8,15,20</td>
                <td>4</td>
              </tr>
              <tr valign="bottom">
                <td>Competiveness<sup>a</sup></td>
                <td>7,10,13,27</td>
                <td>4</td>
              </tr>
              <tr valign="top">
                <td>Security</td>
                <td>8,21,22</td>
                <td>3</td>
              </tr>
              <tr valign="top">
                <td>Improved population health</td>
                <td>2,15,22</td>
                <td>3</td>
              </tr>
              <tr valign="top">
                <td>Continuity of care document</td>
                <td>2,15,40</td>
                <td>3</td>
              </tr>
              <tr valign="bottom">
                <td>Urban/more developed locations/status<sup>a</sup></td>
                <td>2,7,26</td>
                <td>3</td>
              </tr>
              <tr valign="top">
                <td>Knowledge/IT management</td>
                <td>11,13,15</td>
                <td>3</td>
              </tr>
              <tr valign="top">
                <td>Staff retention</td>
                <td>8,16</td>
                <td>2</td>
              </tr>
              <tr valign="top">
                <td>Long run cost savings</td>
                <td>8,31</td>
                <td>2</td>
              </tr>
              <tr valign="top">
                <td>Alignment with strategy</td>
                <td>1,13</td>
                <td>2</td>
              </tr>
              <tr valign="top">
                <td>Project planning</td>
                <td>8</td>
                <td>1</td>
              </tr>
              <tr valign="top">
                <td>Patient empowerment</td>
                <td>1</td>
                <td>1</td>
              </tr>
              <tr valign="top">
                <td>Patient engagement</td>
                <td>14</td>
                <td>1</td>
              </tr>
              <tr valign="top">
                <td>Effectiveness</td>
                <td>32</td>
                <td>1</td>
              </tr>
              <tr valign="top">
                <td>Genome associated care</td>
                <td>31</td>
                <td>1</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>Statistical association identified through retrospective studies, rather than answers to “why” in a survey or interview.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Barriers identified in the literature.</p>
          </caption>
          <table width="601" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="207"/>
            <col width="264"/>
            <col width="98"/>
            <thead>
              <tr valign="top">
                <td>Barriers</td>
                <td>Occurrences by article reference number</td>
                <td>Total occurrences</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Cost</td>
                <td>5,8,12,13,16,17,19,25,28,30,32, 33,34,37,38</td>
                <td>16</td>
              </tr>
              <tr valign="top">
                <td>Time consuming</td>
                <td>5,19,20,32,34,39</td>
                <td>6</td>
              </tr>
              <tr valign="top">
                <td>User perception/perceived lack of usefulness</td>
                <td>5,8,13,17,19,34</td>
                <td>6</td>
              </tr>
              <tr valign="top">
                <td>Transition of data</td>
                <td>13,19,20,22,28,34</td>
                <td>6</td>
              </tr>
              <tr valign="bottom">
                <td>Facility location (rural areas)/characteristics<sup>a</sup></td>
                <td>2,7,14,21,28</td>
                <td>6</td>
              </tr>
              <tr valign="top">
                <td>Implementation issues</td>
                <td>8,13,19,20,25</td>
                <td>5</td>
              </tr>
              <tr valign="top">
                <td>User/patient resistance</td>
                <td>7,9,13,19,20</td>
                <td>5</td>
              </tr>
              <tr valign="top">
                <td>Lack of tech assistance/experience</td>
                <td>13,16,29,33,38</td>
                <td>5</td>
              </tr>
              <tr valign="top">
                <td>Interoperability/no standard protocols for data exchange</td>
                <td>12,21,25,39</td>
                <td>4</td>
              </tr>
              <tr valign="top">
                <td>Medical error</td>
                <td>15,20,23,40</td>
                <td>4</td>
              </tr>
              <tr valign="top">
                <td>Training, maintenance, upgrades</td>
                <td>8,12,20,23</td>
                <td>4</td>
              </tr>
              <tr valign="top">
                <td>Lack of agility to make changes</td>
                <td>20,32,39</td>
                <td>3</td>
              </tr>
              <tr valign="top">
                <td>Staff shortages/overworked</td>
                <td>2,26,39</td>
                <td>3</td>
              </tr>
              <tr valign="top">
                <td>Privacy and/or security</td>
                <td>13,35,36</td>
                <td>3</td>
              </tr>
              <tr valign="top">
                <td>Missing data</td>
                <td>15,20,40</td>
                <td>3</td>
              </tr>
              <tr valign="bottom">
                <td>External factors<sup>a</sup></td>
                <td>8,26,38</td>
                <td>3</td>
              </tr>
              <tr valign="top">
                <td>Competiveness</td>
                <td>12,10,27</td>
                <td>3</td>
              </tr>
              <tr valign="bottom">
                <td>Provider or patient age<sup>a</sup></td>
                <td>7,29</td>
                <td>2</td>
              </tr>
              <tr valign="bottom">
                <td>Race &#38; income disparities<sup>a</sup></td>
                <td>2,15</td>
                <td>2</td>
              </tr>
              <tr valign="top">
                <td>Lack of infrastructure and/or space for systems</td>
                <td>17,19</td>
                <td>2</td>
              </tr>
              <tr valign="top">
                <td>Need organizational cultural change</td>
                <td>8,38</td>
                <td>2</td>
              </tr>
              <tr valign="top">
                <td>Lack of incentives</td>
                <td>12</td>
                <td>1</td>
              </tr>
              <tr valign="top">
                <td>IMGs less likely to adapt</td>
                <td>26</td>
                <td>1</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table3fn1">
              <p><sup>a</sup>Statistical association identified through retrospective studies, rather than answers to “why” in a survey or interview.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        
        <p>The barrier most often identified in the literature was cost (17%, 16/95). This factor included the following: <italic>initial cost, implementation cost, maintenance cost</italic>, and <italic>training cost</italic>. The barriers of <italic>too time consuming, user perception/perceived lack of usefulness, transition of data,</italic> and <italic>facility location</italic> were each identified 6% of the time (6/95). <italic>Implementation issues, user/patient resistance</italic> and <italic>lack of technical assistance or experience</italic>, were listed 5% of all occurrences (5/95). <italic>Lack of interoperability, medical error, training, maintenance, and upgrades</italic> were all listed 4% of all occurrences (4/95). The rest of the barriers were mentioned three or less times, so we grouped them into a category of miscellaneous.</p>
        <p>As depicted in <xref ref-type="table" rid="table2">Tables 2</xref> and <xref ref-type="table" rid="table3">3</xref>, two facilitating factors and four barriers to EHR adoption are followed by a superscript letter. These factors appeared in the literature, but they were identified through statistical associations by researchers conducting retrospective studies. We included these factors in the review because the retrospective studies add value overall, but they are set apart because they are factors that really cannot be easily changed; therefore, they do not offer administrators and policy makers much actionable information.</p>
        <p>From the 31 articles included in the review, 3 (10%) were reviews, and 9 (29%) were mixed methods. The remaining articles were a combination of retrospective, observational, cross-sectional, or descriptive. Of the articles reviewed, 17 (55%) analyzed secondary data, 12 (39%) collected primary data, and 4 (13%) used a mixture of sources. Thirteen (42%) of the articles in the review collected primary data through a survey, interview, or combination of both.</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>We found it interesting how often perception plays into interviews and surveys, and in the case of this review, resulted in one or more factors appearing as both an enabler and a barrier, based on the perception of the interviewee. Error is one example of that phenomenon. It is listed as a facilitator (mentioned 4% of the time), <italic>using the EHR to prevent error</italic> [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>] and as a barrier (mentioned 4% of the time), <italic>use of the EHR can cause error</italic> [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. User perceptions were also listed on both sides for monetary factors: the cost-related facilitator was <italic>incentives</italic> (mentioned 5% of the time), and the cost-related barrier was <italic>cost</italic> (mentioned 17% of the time). One more dichotomy was time-related factors: the facilitator factor, <italic>efficiency</italic> (mentioned 12% of the time), and the barrier, <italic>time consuming</italic> (mentioned 6% of the time). Some interviewees listed <italic>ability to transfer information</italic> (6%) as a facilitator, while others listed <italic>interoperability/no standard protocols for data exchange</italic> (4%) as a barrier.</p>
        <p>Results from this review are in line with others performed along the same lines. Cost is repeatedly a primary barrier to the adoption of the EHR [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref26">26</xref>, <xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. Several factors were reinforced by this review that highlight organizational characteristics such as size and location [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. Location is a difficult barrier to overcome. It is not a mystery to anyone that rural communities often struggle to overcome barriers such as cost, bandwidth, and user/patient acceptance, a point supported by the literature [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. Unfortunately, very few solutions are offered to this group; at a minimum policy should look to assist those who lag behind the rest of the adopters [<xref ref-type="bibr" rid="ref29">29</xref>]. Small, rural communities are the slowest to adopt, and their size is a major disadvantage in terms of budget and technical agility. Policy should look to a range of factors to lever, such as organizational, cultural, technological, and financial considerations [<xref ref-type="bibr" rid="ref9">9</xref>].</p>
        <p>Many factors play a role in establishing an environment conducive to the adoption of the EHR. This review was not intended to establish causality, but instead, it was designed to identify the frequency with which facilitators and barriers are discussed in the literature. It is hoped that by this review, data-driven studies can be developed to strengthen the validity of the factors listed.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This paper provides a review of the factors associated with adoption of EHR systems. Interrater reliability was calculated for both the search terms and titles selected, as well as the consensus-building activity surrounding the final selection of the 31 articles. In that regard, reliability of the results are strong.</p>
        <p>Validity was strengthened by these results aligning with those of previous reviews. This addresses internal validity, but external validity would be limited to the United States because articles that focused on other countries were excluded from the review. Another limitation is that EHR adoption and usage were often self-reported by physicians, and social-desirability bias may have led physicians to overestimate actual usage.</p>
      </sec>
      <sec>
        <title>Conclusion</title>
        <p>Users and nonusers alike are concerned about similar topics such as efficiency, quality, and interoperability. This review supports the findings of other reviews. Additional research remains necessary to assess the EHR system adoption factors in health care organizations in future years. Within the constantly changing environment of health care in the United States, health care decision makers are gradually adopting the EHRs, but adoption is far from ubiquitous. Country-level advantages will likely not emerge until everyone adopts a fully interoperable EHR.</p>
      </sec>
    </sec>
  </body>
  <back>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">CINAHL</term>
          <def>
            <p>Cumulative Index of Nursing and Allied Health Literature</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">EBSCO Host</term>
          <def>
            <p>Ebson B Stephens Company</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">EHR</term>
          <def>
            <p>electronic health records</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">EMR</term>
          <def>
            <p>electronic medical records</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">GDP</term>
          <def>
            <p>gross domestic product</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">HITECH</term>
          <def>
            <p>The Health Information Technology for Economic and Clinical Health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">MeSH</term>
          <def>
            <p>Medical subject headings from the American National Library of Medicine</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>We would like to acknowledge Texas State University for using their library database for our research.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="web">
        <source>U.S. Center for Medicare and Medicaid Services</source>  
        <access-date>2016-01-14</access-date>
        <comment>Historical national health expenditures
        <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="https://www.cms.gov/research-statistics-data-and-systems/statistics-trends-and-reports/nationalhealthexpenddata/nationalhealthaccountshistorical.html">https://www.cms.gov/research-statistics-data-and-systems/statistics-trends-and-reports/nationalhealthexpenddata/nationalhealthaccountshistorical.html</ext-link>
        <ext-link ext-link-type="webcite" xlink:href="6eX1NDL1Y"/></comment> </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
        <person-group person-group-type="author">
          <name name-style="western">
            <surname>Samuel</surname>
            <given-names>CA</given-names>
          </name>
        </person-group>
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